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Fluorine-substituted apatite coating on surface of biologic medical magnesium or alloy thereof and preparation method

A biomedical, apatite technology, applied in the field of medicine, can solve the problems of surrounding tissue inflammation, prolong the crystallization period of bone salt, reduce the stability of new bone tissue, etc., achieve good thermal stability and biological stability, and firm combination , The effect that the degradation cycle can be adjusted

Active Publication Date: 2010-05-12
CHANGSHU MICROTUBE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the current magnesium materials have the following problems in medical applications: the initial degradation rate of magnesium and its alloy materials is too fast, causing inflammation in the surrounding tissues; the degradation products containing magnesium ions will prolong the crystallization of bone salt (bone-like apatite) cycle, reducing the stability of new bone tissue, resulting in poor integration of the interface between the implant and the surrounding new bone tissue and symptoms such as osteoporosis
However, this type of deposition product itself has a loose structure, cannot effectively slow down the corrosion degradation of magnesium, and is not osteoinductive.

Method used

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  • Fluorine-substituted apatite coating on surface of biologic medical magnesium or alloy thereof and preparation method
  • Fluorine-substituted apatite coating on surface of biologic medical magnesium or alloy thereof and preparation method
  • Fluorine-substituted apatite coating on surface of biologic medical magnesium or alloy thereof and preparation method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Step 1, preparing a deposition solution, the composition of 1L of the deposition solution is:

[0027] CaCl 2 0.002mol, NaH 2 PO 4 2- 0.001mol, MgF 2 1×10 -5 mol, the balance is pure water;

[0028] Step 2, after surface cleaning, degreasing and necessary activation process, the biomedical magnesium rare earth alloy stent is soaked in the deposition solution prepared in step 1, and the pH of the deposition solution is adjusted to 7.4;

[0029] The deposition solution was then placed in a cell culture incubator (CO 2 Partial pressure is 5%), the temperature is set to 30 DEG C, after 24 hours, the thickness is 0.1 micron thick coating, the main component of the coating is short rod-shaped carbonate-fluorine mixed substituted apatite, The structural formula is: (Ca, Na 2 ) 10 (PO 4 ) 6-2y (CO 3 ) 3y (OH) 2-z f z , where y=2.9, z=0.1;

[0030] Step 3, annealing the coated bracket at 150° C. for 24 hours can be used as an orthopedic implant material.

Embodiment 2

[0032] Step 1, preparing a deposition solution, the composition of 1L of the deposition solution is:

[0033] 0.1mol Ca(NO 3 )·4H 2 O, 0.05mol NH 4 h 2 PO 4 , 0.01mol NaF, the balance is pure water;

[0034] Step 2, placing the biomedical magnesium-aluminum alloy AZ91 screw in the deposition solution prepared in step 1, adjusting the pH of the deposition solution to 3.0, and the temperature to 55°C, so that the fluorine replaces the apatite coating for spontaneous deposition;

[0035] At the same time, the structure of the coating is controlled by electrochemical assisted deposition. The specific parameters are: the inert electrode silver electrode is used as the anode, and the AZ91 magnesium aluminum alloy is used as the cathode for electroplating, and the current density is controlled at 20mA / cm 2 , the entire deposition process is carried out under the protection of nitrogen or argon, and after 2 hours, acicular fluorine-substituted hydroxyapatite coating with a thickn...

Embodiment 3

[0039] Step 1, preparing a deposition solution, the composition of 1L of the deposition solution is:

[0040] Ca(NO 3 ) 2 1mol, NaHPO 40.5mol, SnF 0.1mol, anti-precipitation agent NaSiO 3 12H 2 O 0.01mol, the balance is pure water;

[0041] Step 2, adjust the pH of the deposition solution to 5.0, and the temperature to 90°C; use the biomedical Mg-1%Zn-%1Ca ternary magnesium alloy as the anode, and use the inert electrode as the cathode to carry out anodic oxidation. The specific reaction parameters are: anode voltage 95V, the current density is 160mA / cm 2 , the treatment time was 600 minutes; as a result, a coating with a thickness of 2 mm was obtained, and the main component of the coating was acicular fluorine mixed substituted apatite, (Ca, Mg, Na 2 ) 10 (PO 4 ) 6 (OH) 2-x f x , where x=1.9;

[0042] In step three, the ternary magnesium alloy covered with the coating obtained in step two is annealed at 400 ° C for 0.5 hours, which can be used as a medical implan...

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Abstract

The invention relates to a fluorine-substituted apatite coating on the surface of biologic medical magnesium or alloy thereof in the technical field of the medicine and a preparation method; the components of the coating are shown as the following molecular formula (1) or (2): (1) (Ca, M) 10 (PO4) 6 (OH) 2-xFx, 0<x<=2; (2) (Ca, N) 10 (PO4) 6-2y (CO3) 3y (OH) 2-zFz, 0<y<=3, 0<z<=2; and the preparation method of the coating comprises the following steps: preparing deposition liquid; immersing the medical magnesium or the alloy thereof in the deposition liquid, regulating the pH of the deposition liquid to 3.0-7.4 and the temperature of the deposition liquid to 30-90 DEG C and carrying out spontaneous deposition on the fluorine-substituted apatite coating; and after completing the deposition, heating to obtain the fluorine-substituted apatite coating. The coating overcomes the defects of large friability and short degradation period of a pure hydroxylapatite implantation material and has favorable thermal stability and biologic stability.

Description

technical field [0001] The invention relates to a coating and a preparation method in the technical field of medicine, in particular to a fluorine-substituted apatite coating on the surface of biomedical magnesium or its alloy and a preparation method. Background technique [0002] Implantable magnesium or its alloys are a new generation of metal biomedical materials that can be degraded and absorbed in vivo, especially for promoting the growth of new bone tissue. However, the current magnesium materials have the following problems in medical applications: the initial degradation rate of magnesium and its alloy materials is too fast, causing inflammation in the surrounding tissues; the degradation products containing magnesium ions will prolong the crystallization of bone salt (bone-like apatite) Cycle, reduce the stability of new bone tissue, resulting in poor integration of the implant and the surrounding new bone tissue interface and symptoms such as osteoporosis. To ove...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/32A61L27/04A61L27/58A61K6/04A61K6/033A61K6/838
Inventor 宋阳张小农张绍翔李佳楠赵常利戎虎威
Owner CHANGSHU MICROTUBE TECH
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