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Medical metal-based titanium oxide-hydroxyapatite nano-composite coating material and preparation method thereof

A nano-composite coating and hydroxyapatite technology, which is applied in coatings, medical science, prostheses, etc., can solve the problem that the mechanical properties and biocompatibility of composite coatings are difficult to achieve, and the uniform dispersion of oxide particles cannot be achieved. Improve the mechanical strength and thermal expansion performance, enhance the thermal expansion coefficient, and the effective thermal expansion coefficient for problems such as the decline in biocompatibility of the composite coating

Inactive Publication Date: 2009-12-16
HUNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Because nano powders are easy to agglomerate, agglomerate, and settle, and it is difficult for micron-sized oxides to be uniformly dispersed in the nano-calcium phosphate phase, even though various dispersion techniques such as mechanical grinding and stirring, ultrasonic waves, etc. To realize the uniform dispersion of oxide particles in the final composite coating, the biocompatibility of the composite coating is reduced due to oxide agglomeration in some parts, and the mechanical properties of some parts are not good due to the absence of oxide particles , that is, the composite coating is difficult to achieve the expected modification effect in terms of mechanical properties and biocompatibility

Method used

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Effect test

Embodiment 1

[0032] The medical metal-based titanium oxide-hydroxyapatite nanocomposite coating material of this embodiment includes a medical metal substrate, and its surface is a composite coating composed of mutually uniformly dispersed titanium oxide crystal grains and hydroxyapatite crystal grains. In the composite coating, the particle diameters of titanium oxide crystals and hydroxyapatite crystals are 30-39 nm and 55-63 nm respectively, and the average thickness of the coating is 38.7 μm.

[0033] Preparation: 1) Preparation of titanium sol: take by weighing 20% ​​TiCl 3 15.45g of the solution was prepared with 293.55mL of deionized water to obtain TiCl with a mass percentage of 1%. 3 solution, under stirring conditions to TiCl 3 The solution was dripped with a concentration of 10wt% ammonia solution 380mL; subsequently, the TiCl 3 The system formed after the complete reaction of the solution and the ammonia solution is transferred into a centrifuge tube, and centrifuged at a cen...

Embodiment 2

[0041] The medical metal-based titanium oxide-hydroxyapatite nanocomposite coating material of this embodiment includes a medical metal substrate, and its surface is a composite coating composed of mutually uniformly dispersed titanium oxide crystal grains and hydroxyapatite crystal grains. In the composite coating, the particle sizes of titanium oxide crystals and hydroxyapatite crystals are 41-48 nm and 115-146 nm respectively, and the average thickness of the coating is 232.5 μm.

[0042] Preparation: 1) Preparation of titanium sol: take by weighing 20% ​​TiCl 3 77.25g of the solution was prepared with 77.25mL of deionized water to obtain TiCl with a mass percentage of 10%. 3 Solution, under medium-speed stirring conditions, the prepared TiCl 3 400mL of 10wt% sodium hydroxide solution was added dropwise in the solution; subsequently, the TiCl 3 The system formed after the complete reaction of the solution and the sodium hydroxide solution is transferred to a centrifuge tu...

Embodiment 3

[0049] The medical metal-based titanium oxide-hydroxyapatite nanocomposite coating material of this embodiment includes a medical metal substrate, and its surface is a composite coating composed of mutually uniformly dispersed titanium oxide crystal grains and hydroxyapatite crystal grains. In the composite coating, the particle sizes of titanium oxide crystals and hydroxyapatite crystals are 32-40 nm and 92-110 nm respectively, and the average thickness of the coating is 98.0 μm.

[0050] Preparation: 1) Preparation of titanium sol: weigh 50% TiCl 4 60.8g of the solution was prepared with 91.2mL of deionized water to obtain TiCl with a mass percentage of 20%. 4 Solution, under medium-speed stirring conditions, the prepared TiCl 4 200 mL of 15% ammonia solution was added dropwise to the solution; subsequently, the TiCl 4 The system formed after the complete reaction of the solution and the ammonia solution is transferred into a centrifuge tube, and centrifuged at a centrifug...

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Abstract

A medical metal-based titanium oxide-hydroxyapatite nano-composite coating material and a preparation method thereof are disclosed, the medical metal-based titanium oxide-hydroxyapatite nano-composite coating material of the invention comprises a medical metal substrate, the surface of which is a composite coating composed of mutually evenly-dispersed titanium oxide crystal grains and hydroxyapatite crystal grains, in the composite coating, grain sizes of titanium oxide crystal and hydroxyapatite crystal are 30-50nm and 50-150nm, respectively. The invention further comprises the preparation method of the medical metal-based titanium oxide-hydroxyapatite nano material, namely hybrid sol-gel method. The medical metal-based titanium oxide-hydroxyapatite nano-composite coating of the invention is obviously improved in mechanical strength and thermal expansion performance and has the bonding strength reaching 25-45 MPa with medical metal.

Description

technical field [0001] The invention relates to a metal-based titanium oxide-hydroxyapatite nanocomposite material and a preparation method thereof, in particular to a medical metal-based titanium oxide-hydroxyapatite nanocomposite coating material and a preparation method thereof. Background technique [0002] The medical metal-based bioceramic coating system formed by coating the surface of medical metals, such as pure titanium, titanium alloy, stainless steel, magnesium alloy, zinc alloy, cobalt alloy, etc., with bioceramic coatings such as hydroxyapatite and calcium phosphate, because At the same time, it has good mechanical properties of medical metals and excellent biocompatibility of bioceramics, and has very important application value in the field of human hard tissue repair and replacement. [0003] Medical metals are usually bioinert or biotoxic materials, therefore, they are not suitable for long-term direct application to the human body. In order to improve the...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/30A61L27/12A61L27/02
Inventor 吴振军李文生袁剑民任艳群周小平
Owner HUNAN UNIV
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