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Stereolithography-based process for manufacturing porous structure of bionic scaffold

A technology of porous structure and manufacturing process, applied in the field of artificial bone, can solve the problems of inability to guarantee the conduction of holes, bionic design and manufacturing, poor process controllability, etc., and achieves favorable adhesion, high accuracy, and biocompatibility. Good results

Inactive Publication Date: 2009-09-23
SHANGHAI UNIV +1
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Problems solved by technology

[0005] At present, the general forming methods for constructing artificial bone microscopic channel system include pore forming method, foaming pore forming method, thermally induced phase separation method, fiber weaving method, extrusion forming method and embossing forming method, etc., but these methods There are defects that the holes cannot guarantee conduction, the process controllability is poor, and the bionic design and manufacture of the microstructure cannot be carried out.

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  • Stereolithography-based process for manufacturing porous structure of bionic scaffold
  • Stereolithography-based process for manufacturing porous structure of bionic scaffold
  • Stereolithography-based process for manufacturing porous structure of bionic scaffold

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Embodiment Construction

[0022] A preferred embodiment of the present invention is described in detail in conjunction with the accompanying drawings as follows: First, the manufacturing process of the biomimetic scaffold porous structure based on photocuring has the following steps: see figure 1 , using Micro-CT to scan natural bone to obtain tomographic images of microscopic three-dimensional porous structure information and three-dimensional spatial position density information of cancellous bone. Threshold processing is performed on each of the above-mentioned tomographic images to obtain a binarized image. After selecting the image range and calculation accuracy, and setting the parameter values ​​of the generated 3D model, a porous structure bone model constructed from digital data can be obtained.

[0023] Later, see figure 2 , by removing microstructures smaller than 300 μm and processing with Boolean operations, a computer three-dimensional negative model is obtained.

[0024] Finally, see ...

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Abstract

The invention relates to a stereolithography-based process for manufacturing the porous structure of a bionic scaffold. The process comprises the following steps: scanning natural bones by Micro-CT to acquire the micro-structural model of the natural bones; further acquiring the negative-type model thereof through the Boolean operation; then, acquiring the negative-type model on a stereolithography basis; and finally pouring bioceramic slurry followed by high-temperature calcinations to obtain the controllable porous structure of the bionic scaffold. The porous structure of the bionic scaffold prepared by the method is the same as the real structure of bones; moreover, the method is even more favorable for the adhesion, creeping and osteogenesis substitution of cells.

Description

technical field [0001] The invention relates to an artificial bone for orthopedic medical repair, in particular to a manufacturing process for a porous structure of a bone bionic support based on photocuring. Background technique [0002] Bone plays a pivotal role in the human body. It is a common problem in clinical medicine to lose a certain amount of bone mass due to various traumas, tumors or infections to form bone defects with large gaps. The repair problem of a small segment of bone can be repaired through the regeneration of human biological tissue (osteoblast reproduction and crawling), and the damaged bone tissue can recover by itself. Once the damaged bone tissue exceeds 30mm, it cannot be repaired by the growth of the bone itself. How to promote the healing of bone defects as soon as possible has always been a problem to be solved in the field of orthopedics. [0003] The method of tissue engineering overcomes the shortcomings of traditional treatment methods, ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/82A61F2/28A61L27/56A61L27/10
Inventor 林柳兰戎斌张加峰胡庆夕方明伦赵莉
Owner SHANGHAI UNIV
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