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Use of deuteroporphyrin derivates

A technology of hypoporphyrin and derivatives, which is applied in the field of medicine, can solve the problems of long light-shielding time, complex components, and unclear functions, and achieves the effects of stable effect, small side effects, and strong effect.

Active Publication Date: 2009-07-01
上海复旦张江生物医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Photosensitizers represented by HpD belong to the first generation of photosensitizers, their components are complex, and the role of various components in photodynamic damage has not been clarified so far. It cannot produce effective photodynamic damage to the diseased target tissue, but becomes the culprit that causes photosensitivity in normal tissue
Therefore, the tissue selectivity and photodynamic damage intensity stability of the first generation of photosensitizers are poor, and it is easy to cause skin photosensitivity reaction, and the time of avoiding light is long
In addition, the absorption spectrum of mixed porphyrin photosensitizers has a very weak absorption band in the red part, which cannot absorb red light well, and the treatment depth is not enough, which also affects its clinical efficacy

Method used

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  • Use of deuteroporphyrin derivates
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  • Use of deuteroporphyrin derivates

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1 In vitro photodynamic effect of doteporfin on growth inhibition of human tumor cell lines.

[0041] Dotepofin is prepared according to Chinese patent CN1130364, and the preparation method is as follows: dilute with physiological saline for injection to the required concentration, and prepare and use immediately.

[0042] Positive control drug: hematoporphyrin injection (Beijing Institute of Pharmaceutical Industry, batch number: 981202) Preparation method: dilute with physiological saline for injection to the required concentration, and prepare immediately for immediate use.

[0043] Light source: IEAu-3 type gold vapor laser, laser wavelength 627.8nm, produced by Beijing Institute of Electronics, Chinese Academy of Sciences. Tumor cell lines:

[0044] Table 1 Human solid tumor cell lines used in the test

[0045]

[0046] normal control cells

[0047]

[0048] *Abbreviation: ATCC: American Type Culture Collection

[0049] NCI: National Cancer Instit...

Embodiment 2

[0063] Example 2 Photodynamic therapy effect of doteporfin on human squamous cell carcinoma KB, human gastric adenocarcinoma MKN-28, and human colon adenocarcinoma HCT-116 in nude mice.

[0064] Dotepofin is prepared according to Chinese patent CN1130364, and the preparation method is as follows: dilute with physiological saline for injection to the required concentration, and prepare and use immediately.

[0065] Positive control drug: hematoporphyrin injection (Beijing Institute of Pharmaceutical Industry, batch number: 981202) Preparation method: dilute with physiological saline for injection to the required concentration, and prepare immediately for immediate use.

[0066] BALB / cA nude mice were provided by Shanghai Institute of Materia Medica, Chinese Academy of Sciences. Age in days: 35-40 days, weight: 18-22g, gender: both male and female, the same batch of tests are of the same sex. Number of animals in each group: 12 in the negative control group and 6 in the treatme...

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Abstract

The invention belongs to the technical field of medicament and specifically relates to use of a deuteroporphyrin derivative. The invention provides use of deuteroporphyrin derivative in preparing medicament for treating squamous carcinoma or adenocarcinoma. The treatment with the deuteroporphyrin derivative or composition and medicament thereof to squamous carcinoma or adenocarcinoma has obvious growth-inhibiting effect and good dose effect relationship. A group with high dosage has strong and stable effect and stronger inhibiting effect than the positive control medicament, hemoporphyrin. The deuteroporphyrin derivative has no growth-inhibiting effect on tumour cells under a condition of non-laser radiation, no damaging effect on normal histiocytes with light or without light and little side effect.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the use of hypoporphyrin derivatives. Background technique [0002] Squamous cell carcinoma (squamous cell carcinoma) is referred to as squamous cell carcinoma, which often occurs in parts of the body covered by squamous epithelium, such as skin, mouth, lips, cervix, vagina, esophagus, and larynx. Some parts, such as bronchi, gallbladder, renal pelvis, etc., are not covered by squamous epithelium normally, but squamous cell carcinoma can occur through squamous metaplasia. This cancer is often cauliflower-shaped to the naked eye, and can also form ulcers due to necrosis and shedding of cancer tissue. At the same time, the cancer tissue also grows invasively to the deep layer. [0003] Adenomas are tumors that arise from the glandular epithelium, and are more common in the thyroid, ovary, breast, salivary glands, and intestines. The adenomas of mucosal glands are mostly polypoi...

Claims

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Application Information

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IPC IPC(8): A61K31/41A61P35/00
Inventor 陈文晖陶纪宁苏勇张文伯
Owner 上海复旦张江生物医药股份有限公司
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