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Improved cataplasm ground-mass and use thereof

A technology of cataplasm and matrix, which is applied in the field of cataplasm matrix, which can solve the problems of increasing the sensitization of cataplasm and losing the anaphylaxis of cataplasm, so as to improve the formability and ductility, and improve the adhesion Effect

Inactive Publication Date: 2009-04-29
CHONGQING PHARMA RES INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Caterpillars generally use water-based matrix as the carrier, which is not easy to cause allergic reactions in the body. This has always been a major feature and advantage of cataclysms. However, in order to achieve a satisfactory sticking effect, pressure-sensitive adhesives are used, which increases the Possibility of sensitization of cataplasm due to pressure-sensitive adhesives, making cataplasms lose the advantage of non-allergic

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0114] prescription

[0115] Glycerin 20g Azone 2g Polyethylene glycol 400 10g Titanium dioxide 0.5g Partially neutralized sodium polyacrylate NP700 5g Gelatin 3g Cross-linked povidone XL-10 1g Tartaric acid 0.5g Aluminum glycylate 0.02g Magnesium aluminum silicate 2.5g Peppermint oil 0.5 g sodium carboxymethylcellulose 2g disodium edetate 0.05g methylparaben 0.2g deionized water 52.7g

[0116] Preparation:

[0117] a Disperse and dissolve methylparaben in polyethylene glycol 400, then add azone, glycerin, peppermint oil, and disodium edetate and stir well to obtain a glycerin mixture, and mix aluminum glycolate with magnesium aluminum silicate Disperse in the glycerin mixture, then grind titanium dioxide and add and disperse in the above glycerin mixture to obtain a mixed system, then disperse sodium carboxymethylcellulose in the above system, pass gelatin and NP700 through a 200-mesh sieve and cross-link Mix povidone XL-10 evenly, and then disperse in the above system;

...

Embodiment 2

[0121] prescription

[0122] Glycerin 50g Azone 2g Polyethylene glycol 400 5g Titanium dioxide 0.3g Partially neutralized sodium polyacrylate NP600 2g Gelatin 2g Cross-linked povidone XL-10 1g tartaric acid 1.0g Aluminum glycylate 0.02g Aluminum hydroxide 3.2g Peppermint oil 1.0g Sodium carboxymethylcellulose 2g Disodium edetate 0.02g Methylparaben 0.4g Deionized water 30.0g

[0123] Preparation:

[0124] a Disperse and dissolve methylparaben in polyethylene glycol 400, then add azone, glycerin, peppermint oil, EDTA-2Na and stir evenly, disperse aluminum glycerol and aluminum hydroxide in glycerol, and then add titanium dioxide Grind and disperse in the above glycerin mixture, then disperse sodium carboxymethyl cellulose in the above system, then mix 200 mesh gelatin, 200 mesh NP600, and crospovidone XL-10 evenly and disperse in the above system. Can;

[0125] b Tartaric acid is dissolved in 25g of water for later use;

[0126] c Add the tartaric acid in step b to the syst...

Embodiment 3

[0128] prescription

[0129] Glycerin 25g Azone 1g Macrogol 400 10g Titanium dioxide 0.5g Partially neutralized sodium polyacrylate NP600 5g Gelatin 1.5g Cross-linked povidone XL-10 1g Tartaric acid 0.5g Aluminum glycylate 0.02g Magnesium aluminum silicate 2.5g Peppermint oil 0.5g sodium carboxymethylcellulose 1g disodium edetate 0.05g methylparaben 0.2g deionized water 51.2g

[0130] Preparation:

[0131]a Disperse and dissolve methylparaben in polyethylene glycol 400, then add glycerin, azone, peppermint oil, EDTA-2Na and stir evenly, add glycerol and magnesium aluminum silicate to titanium dioxide, grind and disperse in the above glycerin In the mixture, then disperse sodium carboxymethylcellulose in the above system, then mix 200 mesh gelatin, 200 mesh NP700, and crospovidone XL-10 evenly and disperse them in the above system;

[0132] b Tartaric acid is dissolved in 42.2g of water for later use;

[0133] c Add the tartaric acid in step b to the system in step a while s...

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PUM

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Abstract

The invention discloses an improved substrate of a cataplasma and the application thereof to loxoprofen sodium cataplasma. The substrate of the cataplasma adopts the combined application of two or more cross-linking agents and achieves the purposes of increasing the viscosity of a paste and improving the ductibility and moldability of the paste. The application of the substrate can reduce the variety and usage of thickening accessories or can increase the viscosity of the cataplasma to the extent required by a viscous force even without adding special thickening agents. The substrate has advantages in ensuring the good ductibility and moldability of the cataplasma and quickly establishing analytical methods, and the like, thus being significant for the further promotion and application ofthe cataplasma.

Description

technical field [0001] The present invention relates to an improved matrix of cataplasm, which can improve and improve the adhesion, paste extensibility, formability, etc. of cataplasm through the joint application of two or more crosslinking agents performance. The cataplasm of the present invention refers to a cross-linked cataplasm with broad prospects in the field of development and application, including cataplasm with sodium polyacrylate, polyacrylic acid, partially neutralized polyacrylic acid and new polymer materials as the skeleton material Improvement of agent performance. The present invention also relates to the application of the cataplasm matrix of the present invention in drug cataplasms, such as loxoprofen sodium cataplasms. Background technique [0002] How to improve the adhesion of water-based poultices while taking into account the formability and extensibility of poultices has always been a major problem that plagues the application of poultices. Poo...

Claims

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Application Information

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IPC IPC(8): A61K9/70A61K47/34A61K47/38A61K47/10
Inventor 丁彦吉张涛樊斌
Owner CHONGQING PHARMA RES INST
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