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Oral preparation containing amoxicillin and flucloxacillin, preparation method and application thereof

The technology of flucloxacillin and amoxicillin is applied in the field of therapeutic drugs and their preparation, and can solve the problems of long time to reach effective blood drug concentration, easy to cause local pain reaction, influence effective antibacterial effect, etc., so as to avoid pain and inconvenience. , The effect of low production quality requirements and fast onset

Inactive Publication Date: 2008-09-24
北京亿利高科生物工程技术研究所有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In view of the inconvenient use of injections and the tendency to cause local pain reactions when administered
Oral absorption of tablets and capsules is slow, and the drug is diluted in the blood through systemic distribution after entering the blood, so that the blood concentration of the drug in the lesion is lower, and the time to reach the effective blood concentration in the lesion is also longer , affecting its effective antibacterial efficacy

Method used

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  • Oral preparation containing amoxicillin and flucloxacillin, preparation method and application thereof
  • Oral preparation containing amoxicillin and flucloxacillin, preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Example 1 - Amoxicillin Flucloxacillin Sodium Candy

[0050] Prescription: 62.5g of amoxicillin, 62.5g of flucloxacillin sodium, 827.5g of sucrose, 10g of citric acid, 400.1g of food coloring, 10g of mannitol, 27.5g of hypromellose, and the dosage is 1000 tablets.

[0051] Method: Prepare a mixture of 62.5g of amoxicillin, 62.5g of flucloxacillin sodium, 10g of citric acid, 400.1g of food coloring, 10g of mannitol, and 27.5g of hypromellose, grind it, and pass it through a 20-mesh sieve. Take 827.5 grams of sucrose, heat to 140 ° C to melt, cool to 85 ° C, add the sieved mixture, stir rapidly for 10 minutes, place on a product forming machine and extrude, each lozenge weighs 2 grams. Then measure the disintegration time limit of amoxicillin flucloxacillin sodium candy in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0052] Results: the disintegration time limit was 20-27 minutes, and the dissolution rate of amoxicillin and flucloxacillin s...

Embodiment 2

[0053] Example 2-low sugar amoxicillin flucloxacillin sodium candy

[0054] Prescription: Amoxicillin 62.5g, flucloxacillin sodium 62.5g, sucrose 177.5g, fructooligosaccharides 300g, xylitol 300g, inulin 50g, citric acid 10g, food coloring-400.1g, mannitol 10g, hypromellose Cellulose 27.5g, preparation amount 1000 tablets.

[0055] Method: Prepare a mixture of citric acid 10g, food coloring-400.1g, mannitol 10g, and hypromellose 27.5g, grind it, and pass it through a 20-mesh sieve. Take 177.5g of sucrose, 300g of fructooligosaccharide, 300g of xylitol, and 50g of inulin, mix them, heat to 140°C to melt, add the sieved mixture, stir rapidly for 10 minutes, cool to 85°C, add 62.5g of amoxicillin 1. Flucloxacillin sodium 62.5g, stirred rapidly for 10 minutes, placed on the product forming machine and extruded, every buccal tablet weighed 2 grams. Then measure the disintegration time limit of amoxicillin candy in 37 ℃ 900ml water and the dissolution rate when disintegrating comp...

Embodiment 3

[0057] Embodiment 3-Amoxicillin Flucloxacillin Sodium Buccal Tablets

[0058] Prescription: 62.5 grams of amoxicillin, 62.5 grams of flucloxacillin sodium, 128 grams of hypromellose, polyethylene glycol 6000 746 grams, 1 gram of aspartame.

[0059] Method: Prepare 128 grams of hypromellose, polyethylene glycol 6000 746 grams, 1 gram of aspartame mixed matrix, heating and melting, cooling to 80 ° C, adding 62.5 grams of amoxicillin, 62.5 grams of flucloxacillin sodium, stirring and mixing, cooling at room temperature until solidified, granulating, and placing in tablet Extruded on the machine, each lozenge weighs 1 gram. Then measure the disintegration time limit of amoxicillin flucloxacillin sodium buccal tablet in 37 ℃ 900ml water and the dissolution rate when disintegrating completely.

[0060] Results: the disintegration time limit was 28-33 minutes, and the dissolution rate of amoxicillin and flucloxacillin sodium was 92%-96% and 95%-99% when completely disintegrating...

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Abstract

The invention relates to a buccal tablet containing amoxicillin and flucloxacillin, the preparation method and the use. The invention aims to provide a buccal tablet with amoxicillin and flucloxacillin adopted as the medicinal ingredients. The buccal tablet can be dissolved among the salvia in the oral cavity and enter the oral cavity, the pharynx and pharyngeal tonsils to play the role of resisting bacteria. The invention adopts amoxicillin, flucloxacillin and salt derivatives as medicinal ingredients and can be made into various pharmaceutical formulations, such as buccal tablets, candies, dropping pills and so on. The buccal tablet containing amoxicillin and flucloxacillin has the characteristics of fast effect, excellent curative effect and convenient drug delivery, can directly improve the concentration of antibiotic drugs at the pathological part and enhance the antibacterial capacity of the pathological part, and is more suitable for majorities of patients.

Description

technical field [0001] The present invention relates to a therapeutic drug and its preparation method and application, in particular to a buccal preparation containing amoxicillin and flucloxacillin, its preparation method and application. Background technique [0002] Pharyngitis is the most common disease that plagues the lives of modern people. It is a diffuse inflammation of the pharyngeal mucosa, submucosal tissue and lymphoid tissue, and is often a part of upper respiratory tract infection. Clinically divided into acute and chronic two. Acute pharyngitis mostly occurs at the turn of autumn and winter and winter and spring. Lesions often spread to the entire pharyngeal cavity, but can also be limited to one place. It can be caused by viruses, bacteria, physical and chemical factors, high temperature, dust, smoke mold, irritating gases, etc. Bacterial infections were dominated by Gram-positive cocci such as Streptococcus, Staphylococcus and Diplococcus pneumoniae. Am...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/43A61K31/431A61K9/00A61P31/04A61P1/02A61P11/04
Inventor 刘凤鸣
Owner 北京亿利高科生物工程技术研究所有限公司
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