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Biological compatibility magnetic nano crystal for high dissolving and stable distribution in physiologicalbuffer liquid and its making method

A biocompatible, physiological buffer technology, applied in the field of biocompatible magnetic nanocrystals, can solve the problems of solubility and stable dispersion that need to be further improved

Active Publication Date: 2008-08-13
苏州欣影生物医药技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Among them, the biocompatible magnetic fluid obtained by the method described in the 03136273.7 patent is stable for a long time, and the obtained particle dry powder has excellent solubility or dispersibility in water, but the solubility and stable dispersibility in physiological buffers have yet to be determined. to further improve

Method used

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  • Biological compatibility magnetic nano crystal for high dissolving and stable distribution in physiologicalbuffer liquid and its making method
  • Biological compatibility magnetic nano crystal for high dissolving and stable distribution in physiologicalbuffer liquid and its making method
  • Biological compatibility magnetic nano crystal for high dissolving and stable distribution in physiologicalbuffer liquid and its making method

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0061] 1.06g iron acetylacetonate, 12g dicarboxy PEG2000 (prepared according to the document Adv.Mater., 2005, 17 (8), 1001 method), 3.87mL oleylamine were dissolved in 50mL phenyl ether, and then the above solution was transferred to 100mL In the three-necked flask, nitrogen was introduced to remove oxygen for 30 minutes, and the reaction solution was refluxed for 20 hours. The reaction system was cooled to room temperature, and the biocompatible magnetic nanocrystals with carboxyl groups on the surface were precipitated with ether, washed three times, and centrifuged to obtain the biological phase. Capacitive Fe 3 o 4 magnetic nanocrystals. The obtained nanoparticles were dissolved in deionized water, dialyzed for 24 hours, and the obtained solution was precipitated and washed with a mixture of ether and acetone (volume ratio of 3:1), and dried in vacuum to obtain a dry powder that was easy to store and transport. Dissolve the dry powder in deionized water, and use transmi...

Embodiment 2

[0063] Place the dry powder sample obtained in Example 1 at room temperature for half a year, weigh 0.6g, add 100mL of 0.01M PBS (phosphate buffer saline, pH=7.4) to dissolve it completely, and prepare a 6g / L magnetic fluid. After the fluid was placed for half a year, there was no precipitation. Accompanying drawing 4 is the photo that this ferrofluid is placed next to the magnet after half a year.

Embodiment 3

[0065] 0.53g iron acetylacetonate, 6g monocarboxy PEG2000 (prepared according to the document Adv.Mater., 2005, 17 (8), 1001 method) and 1.93mL oleylamine were dissolved in 25mL phenyl ether to make a reaction solution, and then the reaction solution Transfer to a 50mL three-neck flask, fill with nitrogen to remove oxygen for 30 minutes, reflux the reaction solution for 12 hours, cool the reaction system to room temperature, and precipitate the obtained magnetic nanocrystals with ether, wash them three times with ether, and centrifuge to obtain Fe 3 o 4 nanocrystals. After it was naturally dried, it was dissolved in deionized water, and then dialyzed for 24 hours. The dry powder of magnetic nanocrystals obtained by the same method as in Example 1 still shows very good solubility in physiological buffer solution after long-term storage, and the solubility is as high as 50 g / L. Figure 5A is a transmission electron micrograph of the obtained magnetic nanocrystals. Figure 5B is...

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Abstract

The present invention relates to a magnetic nano crystal which is prepared with the ''one-port'' method and can be highly dissolved and steadily dispersed in the biological buffer liquid. Under the condition that the biocompatibility polymer exits or the biocompatibility polymer, the small-molecule amine with alkyl chain, carboxyl acid or alcohol exist together, the metal precursor is decomposed with high temperature in the high boiling point nonpolar or high boiling point weak-polar solvent for preparing the high-crystallinity magnetic nano crystal with different kind, different dimension and different shapes. The technical method adopted by the invention has the characters of simple technique, easy operation. The grain diameter of the magnetic nano crystal prepared with the technique has the advantages of uniformity, controllability, high crystallinity, strong magnetic response and good biocompatibility. Most important, the dry powder of the obtained magnetic nano crystal still represents excellent dissolvability after placing in the biological buffer liquid for a long time. Therefore, the biocompatibility magnetic nano crystal prepared by the technical method has the characters of easy storing and transportation, and is suitable for large-scale and commercial production.

Description

technical field [0001] The invention belongs to the fields of material chemistry, nanoscience and biomedicine, and in particular relates to the preparation of high-crystallinity, highly soluble in physiological buffers and non-polar solvents with high boiling points and low-polarity solvents using the "one-pot" method. Stably dispersed biocompatible magnetic nanocrystals. Background technique [0002] Magnetic nanocrystals are widely used in the field of biomedicine, including: magnetic resonance imaging (MRI), cell separation and labeling, DNA separation, magnetothermal treatment of tumors, and targeted drug carriers. However, the magnetic response properties, biocompatibility and stability under physiological conditions of magnetic nanoparticles have always restricted the application of magnetic nanocrystals in the above fields. [0003] At present, the chemical preparation methods of magnetic nanoparticles mainly include: co-precipitation method, high temperature thermal...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): H01F1/00A61K9/14A61K49/06A61K47/00
CPCH01F1/0063
Inventor 高明远呼凤琴鹿现永
Owner 苏州欣影生物医药技术有限公司
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