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Method for preparing medical freeze-dried powder (injection) preparation

A freeze-dried powder and medical technology, which is applied in the field of pharmaceutical preparations, can solve the problems of high energy consumption and long production cycle, and achieve the effects of reducing energy consumption, shortening time-consuming, and shortening the production cycle

Inactive Publication Date: 2008-02-20
丛繁滋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0025] The purpose of the present invention is to cleverly add energy to liquid water and / or solid water from multiple angles, which is beneficial to the escape of water molecules from solid ice, and to solve the production cycle of industrialized production of medical freeze-dried powder (injection) Long, high energy consumption and other problems

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0060] Embodiment 1, scope of application of the present invention

[0061]The present invention is applicable to any medical freeze-dried powder and medical freeze-dried powder injection that need to be freeze-dried, and need to use the method of the present invention to further improve the internal quality of the product, further shorten the production cycle, and further reduce energy consumption during the freeze-drying process. Now take the medical freeze-dried powder injection as an example, the following varieties applicable to the present invention are given without this limitation: acyclovir, azithromycin, oxaliplatin, omeprazole sodium, aztreonam, amifostine, Amrinone, Atracurium Besylate, Ozagrel Sodium, Sodium Ferulate, Ornidazole, Tranexamic Acid, Amrinoid, Azithromycin Sodium Phosphate Monobasic, Aminobutyric Acid, Ampicillin Sodium, Ammonia Cloxacillin sodium, aspirin arginine salt, alfonate, doxorubicin, aclarithromycin, ampirox, oxiracetam, hyaluronidase, pheno...

Embodiment 2

[0062] Embodiment 2, the activation treatment of liquid preparation

[0063] In the present invention, on the premise of substantially not changing the previous liquid preparation process of the medical freeze-dried powder (injection), after all the previous heating procedures of the liquid preparation have been completed, or after the liquid preparation is about to be dispensed into commercially available Before packing into the container, in the liquid storage tank, in the liquid storage tank liquid circulation pipeline, and / or in the pipeline connecting the liquid storage tank and the liquid storage tank, and / or in the connection between the liquid storage tank and the filling machine One or more activation treatments such as ultrasonic crushing, infrared energization, microwave excitation, and magnetization treatment are performed on the liquid medicine in the pipeline of the packaging machine and / or in the pipeline of the filling machine. The production cycle of ordinary ...

Embodiment 3

[0064] Embodiment 3, microwave vacuum freeze-drying method prepares medical freeze-dried powder (injection) agent

[0065] Put the subpackaged liquid preparation in the microwave vacuum freeze-drying equipment, turn on the refrigeration device, and when the surface temperature of the material is close to zero, turn on the microwave radiation for 1 to 5 seconds, so that the large molecular water in the aqueous solution becomes a small molecular group Water is beneficial to shorten the freezing time, facilitate the formation of large crystals of the frozen material, and facilitate the smooth progress of the next step of sublimation. Continue pre-freezing to rapidly cool down the pre-dried material to minus 20-50°C to complete the pre-freezing of the material.

[0066] In the sublimation stage, start the vacuum pump to keep the vacuum degree in the warehouse at 5-80Pa, start the main heating source, which is the microwave magnetron, to heat the material with high energy, so that ...

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Abstract

The present invention aims at adding energy for the liquid water and / or solid water ingeniously from multi-angle and providing a new perspective which is conductive to the escape of the water molecules from the solid ice, the present invention starts from the four angles of ultrasonic disruption, infrared energy adding, microwave activating and magnetization processing, introduces the advantages and the characteristics of the magnetized water, small water molecule clusters and high-energy water into the medical frozen powder (injection) preparations which are produced industrially in a most economical method and to the maximum extend, so as to explore a new path for shortening the production cycle of the normal vacuum frozen drying and further reducing the energy consumption. On the basis, the present invention also provides: a preparation method of medical frozen powder (injection) preparations by infrared vacuum frozen drying, a preparation method of medical frozen powder (injection) preparations by microwave vacuum frozen drying etc.. The two new methods completely overcome the deficiencies of the single channel for transferring the energy of the traditional vacuum frozen drying and can possibly further greatly shorten the production period of the industrial production of the medical frozen powder (injection) preparations, reduce the energy consumption and improve the inherent quality of the products.

Description

technical field [0001] The invention relates to a preparation method of a medical freeze-dried powder (needle) preparation, which belongs to the field of pharmaceutical preparations. Background technique [0002] Compared with water solvent drugs (such as blood preparations, antibiotics, antitoxins, hormones, bacteria, live poison vaccines, anticancer drugs and other biological products and Chinese patent medicines), vacuum freeze-dried powder drugs have: 1) weak enzymatic effect, The original chemical and physiological properties are stable; 2) It can be restored after adding water, which is convenient for long-distance transportation and storage; 3) The storage period can be extended from several weeks or months to several years; 4) The aqueous solution before the drug is dried is stored in the automatic filling machine 5) The dry production process is easy to sterilize, and can strictly control the sterility of batch pharmaceutical containers and personnel. [0003] Comp...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K45/00A61J3/02
Inventor 丛繁滋
Owner 丛繁滋
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