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Nano lanthanum carbonate and orally disintegrating tablet and preparation method

A technology of orally disintegrating tablets and lanthanum carbonate, which is applied in the field of nanomaterials and pharmaceutical sciences, can solve the problems of low adsorption capacity and small specific surface area, and achieve the effect of preventing agglomeration and uniform crystal dispersion

Inactive Publication Date: 2007-11-28
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing lanthanum carbonate crystal particle size is large, so the specific surface area is small, resulting in low adsorption capacity

Method used

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  • Nano lanthanum carbonate and orally disintegrating tablet and preparation method
  • Nano lanthanum carbonate and orally disintegrating tablet and preparation method

Examples

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Effect test

example 1

[0042] First prepare 1wt% gelatin solution, 0.3mol / L sodium carbonate solution, and 0.2mol / L lanthanum chloride solution for use, then take out 50ml of lanthanum chloride solution, add 20ml of gelatin solution, and stir to make it evenly mixed. Use an ice / water mixture water bath to control the temperature at 5°C, add 50ml of sodium carbonate solution, stir for 10 minutes, then raise the temperature at a rate of 3°C / min until it stops at 30°C, react at this temperature for 30 minutes, and then add 1 wt% of dodecyl Sodium alkyl sulfonate 0.2ml, and left for 20min. Put the turbid liquid into a centrifuge for separation for 30 minutes (3000r / min, the same below), take out the sediment, wash with water 3 times, and place the obtained sediment in a crucible. Put the crucible containing the product into a muffle furnace and heat it at a rate of 10°C / min until 400°C, bake it at this temperature for 1 hour, and then cool it down to room temperature naturally to obtain nano-lanthanum c...

example 2

[0044] First prepare 0.1wt% polyoxyethylene solution, 0.06mol / L potassium carbonate solution, and 0.04mol / L lanthanum nitrate solution for use, then take out 50ml of lanthanum nitrate solution, add 20ml of polyethylene glycol solution, and stir to make it evenly mixed. Use an ice / water mixture water bath to control the temperature at 10°C, add 50ml of potassium carbonate solution, stir for 15min, then raise the temperature at a rate of 5°C / min until it stops at 30°C, and react at this temperature for 50min, then add 0.2ml of 0.1wt% Span 80, and leave it for 40min. Put the obtained emulsion into a centrifuge for separation for 40 minutes, take out the sediment, wash it twice with water, and place the obtained sediment in a crucible. The crucible was put into a muffle furnace and fired at a heating rate of 5°C / min until 300°C, fired at this temperature for 0.5 hour, and then naturally cooled to room temperature to obtain nano-lanthanum carbonate crystals.

example 3

[0046]First prepare 10wt% glycerol solution, 1.2mol / L ammonium bicarbonate solution, and 0.9mol / L lanthanum acetate solution for use, then take out 100ml lanthanum acetate solution, add 2ml glycerol solution, and stir to make it evenly mixed. Use an ice / water mixture water bath to control the temperature at 15°C, add 100ml of ammonium bicarbonate solution drop by drop, complete the addition in 20 minutes, stir and react for 5 minutes, then raise the temperature at a rate of 2°C / min until it stops at 25°C, and react at this temperature for 70 minutes , and then adding 0.5ml of Tween 40 with a concentration of 5wt%, and standing for 30min. Put the turbid liquid in a centrifuge for separation for 20 minutes, take out the sediment, wash it with water 4 times, and place the sediment in a crucible. The crucible containing the product was heated in a muffle furnace at a heating rate of 10°C / min until 250°C, baked at this temperature for 1 hour, and then cooled naturally to room tempe...

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Abstract

The present invention is orally disintegrated nanometer lanthanum carbonate tablet and its preparation process. The orally disintegrated nanometer lanthanum carbonate tablet is prepared through one dry tabletting process, which includes the steps of drying the main medicine ingredient and supplementary material, including disintegrant, stuffing, effervescent, etc, sieving and tabletting; or one wet tabletting process, which includes the steps of mixing the main medicine ingredient and partial supplementary material, including disintegrant, stuffing, corrective, etc, sieving, drying, mixing with the other supplementary material and tabletting. The tabletting pressure is 2-15 MPa, and prepared orally disintegrated tablet has hardness of 2-5kg and extracorporeal disintegrating period of 20-80 sec. The orally disintegrated nanometer lanthanum carbonate tablet has high bioavailability, small dosage and high patient' s compliance.

Description

technical field [0001] The invention belongs to the technical field of nanometer materials and the field of pharmaceutical science. Background technique [0002] Hyperphosphatemia is a complication of chronic renal failure, 80% of renal dialysis patients suffer from this disease. The disease may cause bone lesions, skin itching, and even skin ulcers, etc., and also cause damage to the cardiovascular system, and 50% of patients will die as a result. Phosphate binders are currently the mainstay of treatment for hyperphosphatemia. [0003] Phosphate binders chelate phosphorus in food, preventing its absorption from the gastrointestinal tract. The first-generation phosphorus binders are aluminum salts, which can effectively reduce the serum phosphate level in patients with chronic renal failure, but long-term use can lead to dementia and osteomalacia, so its clinical application is limited. Calcium-containing phosphate binders (eg, calcium acet...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K33/24A61P13/12
Inventor 高建平郑伍魁谢佳烨刘宇
Owner TIANJIN UNIV
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