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Surface modified artificial organ and its preparing method

An artificial organ and surface modification technology, which is applied in the field of artificial organ material modification, can solve problems such as difficulty in guaranteeing the performance and safety of artificial organs, inability to perform all-round coating, and lack of excellent anticoagulant properties. Effects of immunity, excellent anticoagulant properties, and good blood compatibility

Inactive Publication Date: 2007-08-29
SUN YAT SEN UNIV
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Problems solved by technology

Chinese patent ZL95111386.0 provides the method of ion beam enhanced deposition to prepare TiO on artificial organs of cardiovascular system 2-x / TiN composite membrane method, which can realize the coating of flat, simple artificial cardiovascular organs (such as the leaflets of artificial heart valves), and the surface of complex artificial cardiovascular organs (such as the valve frame of artificial heart valves). Surface) can not be covered in all directions, so the performance and safety of the artificial organs made by this method are difficult to be guaranteed
[0005] In the prior art, there is no technology that has excellent anticoagulant properties and can be coated uniformly in all directions

Method used

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Examples

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Effect test

Embodiment 1

[0038] Preparation of TiO doped with different light rare earth elements lanthanum or cerium 2 composite nanomaterials

[0039] The preparation method is as follows: weigh 1 part of butyl titanate according to the molar ratio of net value; 0.5-1 part of glacial acetic acid; 12-20 parts of ethanol; 0.2-0.3 part of nitric acid; 0.001-0.2 part of lanthanum nitrate or cerium nitrate Prepare as follows:

[0040] A) in the above-mentioned proportion, in the process of vigorously stirring butyl titanate, add dropwise absolute ethanol;

[0041] B) adding glacial acetic acid dropwise to the mixed solution of butyl titanate and absolute ethanol, and continuing to stir for 15 to 20 minutes to obtain solution (1);

[0042] C) take by weighing nitric acid, dehydrated alcohol and distilled water (the volume ratio of the three is 1: 2 to 0: 2) in the above-mentioned proportion; after dehydrated alcohol and distilled water are mixed, under vigorous stirring, slowly drip nitric acid to obtai...

Embodiment 2

[0048] Preparation of TiO doped with light rare earth elements lanthanum or cerium 2 Composite Coated Artificial Organs

[0049] TiO doped with the above light rare earth elements lanthanum or cerium 2 The nano powder is pressed into a target according to the specifications of the magnetron sputtering equipment, placed on the target stage of the magnetron sputtering equipment, the artificial organ to be modified is placed on the sample stage, and the vacuum is evacuated to 1×10 -4 Pa, pass the argon gas of a certain pressure, turn on the sputtering power supply, because the radio frequency voltage is applied to the target platform, an argon plasma is formed, and the argon ions bombard the light rare earth element lanthanum or cerium doped TiO 2 Composite target, resulting titanium, lanthanum, oxygen atoms or titanium, cerium, oxygen atoms are deposited on the surface of artificial organs, and TiO doped with light rare earth elements lanthanum or cerium is synthesized 2 film....

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Abstract

The invention relates to artificial organs that has taken surface modification process. The surface of artificial organs is coated titanium dioxide composite membrane that has been doped by light rare earth element lanthanum and / or cerium. The thickness of titanium dioxide composite membrane is 20-600nm, and the 60-300nm is optical selection. The mol content of lanthanum and / or cerium is 0.1-20%, and optical selection is 0.2-10%. The composite membrane could be deposited onto surface of base body of artificial organs by magnetron sputtering technology. The blood compatibility, and wear resistance would be entirely improved.

Description

technical field [0001] The invention relates to the technical field of surface modification of inorganic materials, in particular to the modification technology of artificial organ materials. Background technique [0002] With the improvement of people's living standards and the advancement of medical technology, implanted artificial organs and orthopedic implants have been widely used in clinical medicine, such as artificial joints, artificial bones, artificial heart valves, and vascular and gastric tube stents. Most of these implants are made of titanium alloy (Ti6A14V), pyrolytic carbon or high polymer. Due to the lack of biocompatibility of such materials, when they come into contact with blood or body fluids, a series of biochemical reactions will occur, leading to platelet adhesion to form thrombus, or triggering biological reactions such as sensitization, toxicity, and inflammation, resulting in some biological reactions in the body. Physiological negative effects. ...

Claims

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Application Information

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IPC IPC(8): A61L33/02
Inventor 陈弟虎何振辉张麟潘仕荣
Owner SUN YAT SEN UNIV
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