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Medical anticoagulant artificial material and preparing method thereof

An artificial material and anti-coagulation technology, applied in anti-coagulation treatment, medical containers, medical packaging, etc., to achieve high tensile strength, high elongation at break, and good anti-coagulation effect

Inactive Publication Date: 2003-11-12
李潮
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is just to develop a kind of novel medical anticoagulant artificial material, overcome the deficiency of above-mentioned prior art Chinese anticoagulant artificial material

Method used

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  • Medical anticoagulant artificial material and preparing method thereof
  • Medical anticoagulant artificial material and preparing method thereof
  • Medical anticoagulant artificial material and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0062] The medical anticoagulant artificial material of this embodiment is composed of 95% by weight of polyether thermoplastic polyurethane (produced by Tianjin Polyurethane Factory) and 5% by weight of zinc oxide nanomaterial. The particles of the zinc oxide nanomaterial are distributed in the polyether thermoplastic Film materials and pipes formed in polyurethane. Among the zinc oxide nanomaterials, zinc oxide particles ≤50nm account for 97%. Zinc oxide nanomaterials are commercially available.

[0063] The preparation method is as follows: 1) The compounding of zinc oxide nano-materials with 95% by weight polyether thermoplastic polyurethane, with a Shore hardness of 85A and 5% by weight. 2) Use N, N-dimethyl acetamide (Dimethylamide) as a solvent to prepare a 7% by weight polyether thermoplastic polyurethane solution; 3) Use N, N-dimethyl acetamide (Dimethylamide) as a solvent to prepare a 7% by weight polyether thermoplastic polyurethane solution; After adding zinc oxide nan...

Embodiment 2

[0083] The method and equipment are basically the same as in Example 1, except that the material in this example is composed of 99.7% by weight of polyether thermoplastic polyurethane and 0.3% by weight of zinc oxide nanomaterials. Among the zinc oxide nanomaterials ≤50nm Zinc oxide particles account for 80%. The Shore hardness of polyether thermoplastic polyurethane is 95A.

[0084] The method is that the solvent used is N,N-dimethylacetamide (analytical purity), prepared into a 25% by weight polyether thermoplastic polyurethane N,N-dimethylacetamide solution, and stirred at 10,000 rpm for 5 Minutes, shaking for 1.5 hours, natural evaporation of the solvent at room temperature (15°C) for 8 hours, and drying at 80°C for 10 hours. The mechanical properties are average tensile strength 37.8MPa and average elongation at break 391%.

Embodiment 3

[0086] The method and equipment are basically the same as in Example 1, except that the medical anticoagulant artificial material in this example is made of 90% by weight polyester thermoplastic polyurethane (produced by Tianjin Polyurethane Factory) and 10% by weight zinc oxide It is composed of nano-materials, in which zinc oxide particles ≤50nm account for 95%. The shore hardness of polyester thermoplastic polyurethane is 95A.

[0087] The method is to prepare a 20% by weight polyester thermoplastic polyurethane N,N-dimethylacetamide solution, stir for 120 minutes at a rate of 20,000 rpm, shake for 4 hours, and evaporate the solvent naturally at room temperature 30°C for 12 hours. Dry at 70℃ for 18 hours, the results of the dynamic anticoagulation rate test are shown in figure 1 The mechanical properties of curve 1 and curve 3 are shown in Table 3. Table 3 Mechanical properties of polyester thermoplastic polyurethane film material containing 10% by weight of zinc oxide nanomat...

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Abstract

The invention refers to a manmade materials for medicial anticoagulant and the manufacturing method. It solves the problem that anticoagulant problem of blood osculant materials. It is used to produce osculant blood pipe, medicinal appliance and manmade blood vessel. It comprises polyamine ester and metallic oxide nano materials. The method is that the polyamine ester is resolve in N,N-dimethylacetamide or N,N-dimethylformamide and forms the polyamine ester liquid, the metallic oxide nano materials are put into the liquid. Through high-speed mixing, shocking, and moulding, then the solvent is eliminated. The invention has good anticoagulant effect, high stretching intensity and rupture tensibility. The method and craft and the device is simple and the cost is low.

Description

(1) Technical field [0001] The present invention relates to the anticoagulation treatment of surgical articles, such as sutures, catheters, prostheses, and blood treatment or preparation articles, and more specifically, a medical anticoagulation treatment of medical devices, medical articles and artificial organs in contact with blood The artificial material of blood and its manufacturing method. (2) Background technology [0002] All medical artificial materials in contact with biological tissues should have good biocompatibility, including blood compatibility and tissue compatibility. For devices that directly enter blood vessels, such as catheters and artificial blood vessels used in the cardiovascular system. Its blood compatibility is the primary index to evaluate the performance of materials. The primary indicator for evaluating the blood compatibility of medical artificial materials is the influence of such medical artificial materials on the coagulation system, that is, w...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/06
Inventor 李潮
Owner 李潮
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