Micro flow control chip device for liquid surface tension detection

A liquid surface tension, microfluidic chip technology, applied in the direction of surface tension analysis, etc., can solve a large number of samples, microfluidic chip devices without liquid surface tension, can not meet the high throughput and other problems, to achieve easy waterproof treatment, Avoid the effect of precise adjustment and convenient measurement

Inactive Publication Date: 2009-09-09
TSINGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, this method requires a large number of samples, generally a few milliliters to more than ten milliliters of samples; it takes a few minutes to measure a sample, which cannot meet the needs of high-throughput
[0005] There is currently no microfluidic chip device for measuring the surface tension of liquids

Method used

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  • Micro flow control chip device for liquid surface tension detection
  • Micro flow control chip device for liquid surface tension detection
  • Micro flow control chip device for liquid surface tension detection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] 1) Mask design of substrate 1:

[0059] The structure and size design of the groove on the mask film are as attached figure 1 shown. 3 wide vertical first grooves 11 and 5 narrow vertical second grooves 12 are arranged in parallel, and the widths are respectively 0.6mm and 0.15mm. The groove 11 communicates with the vertical second groove 12 and the vertical third groove 13 at the end, and the width of the third horizontal groove 13 is 0.15mm. The number of the first vertical groove 11 and the second vertical groove 12 can be appropriately increased or decreased to control the amount of sample used.

[0060] 2) The making of substrate 1:

[0061] Place the mask film on a 63mm×31.5mm×1.5mm leveling chrome plate and press it tightly, expose it to an ultraviolet lamp with a wavelength of 365nm for 200 seconds, and then develop it in 0.5% sodium hydroxide developer for 40 seconds. After washing with deionized water, heat at 100°C for half an hour. Use chromium etching ...

Embodiment 2

[0065] 1) Mask design of substrate 1:

[0066] The structure and size design of the groove on the mask film are as attached figure 1 shown. 3 wide vertical first grooves 11 and 5 narrow vertical second grooves 12 are arranged in parallel, and the widths are respectively 0.6mm and 0.15mm. The groove 11 communicates with the vertical second groove 12 and the vertical third groove 13 at the end, and the width of the third horizontal groove 13 is 0.15 mm. The number of the first vertical groove 11 and the second vertical groove 12 can be appropriately increased or decreased to control the amount of sample used.

[0067] 2) The making of substrate 1:

[0068] Place the mask film on a 63mm×31.5mm×1.5mm leveling chrome plate and press it tightly, expose it to an ultraviolet lamp with a wavelength of 365nm for 200 seconds, and then develop it in 0.5% sodium hydroxide developer for 40 seconds. After washing with deionized water, heat at 100°C for half an hour. Use chromium etching...

Embodiment 3

[0072] 1) Mask design of substrate 1:

[0073] The structure and size design of the groove on the mask film are as attached figure 1 shown. 3 wide vertical first grooves 11 and 5 narrow vertical second grooves 12 are arranged in parallel, and the widths are respectively 0.6mm and 0.15mm. The groove 11 communicates with the vertical second groove 12 and the vertical third groove 13 at the end, and the width of the third horizontal groove 13 is 0.15 mm. The number of the first vertical groove 11 and the second vertical groove 12 can be appropriately increased or decreased to control the amount of sample used.

[0074] 2) The making of substrate 1:

[0075] Place the mask film on a 63mm×31.5mm×1.5mm leveling chrome plate and press it tightly, expose it to an ultraviolet lamp with a wavelength of 365nm for 200 seconds, and then develop it in 0.5% sodium hydroxide developer for 40 seconds. After washing with deionized water, heat at 100°C for half an hour. Use chromium etching...

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Abstract

The microfluidic chip device for measuring the surface tension of a liquid according to the present invention comprises: a substrate with a vertical first groove and a vertical second groove placed in parallel on its upper surface, and a substrate with a vertical first groove and a vertical second groove on the upper surface. 1. One end of the second vertical groove is connected to a vertical horizontal third groove; the size of the first and second vertical grooves is different; the other end of the first and second vertical grooves extends beyond the edge of the substrate ; a cover plate that is closely attached to the upper surface of the substrate; and a transparent marking plate with a standard international length unit scale pasted on the outer surface of the cover plate; when measuring the sample, only need to introduce the liquid from the end of the groove, and the liquid is in the Driven by the capillary force, it automatically enters the chip and reaches an equilibrium state. The surface tension of the liquid is obtained by measuring the difference in liquid level and combining it with the density of the liquid. Its measurement is simplified, and it can realize fast real-time on-site detection, which has broad application prospects in basic research and industrial production.

Description

technical field [0001] The invention belongs to a microfluidic chip device, in particular to a microfluidic chip device for measuring liquid surface tension. Background technique [0002] In the early 1990s, analytical chemists proposed the idea of ​​Micro Total Analysis System (μTAS). The micro-analysis system integrates the common functions of the entire analytical chemistry laboratory into a centimeter or even millimeter-scale platform, making it miniaturized, automated, highly integrated and portable. This "lab-on-a-chip" includes the functions required in common analysis and detection, including sample injection, pretreatment, separation, detection, etc., which can greatly reduce reagent consumption, shorten analysis time and reduce the amount of samples used. It is very suitable for special experimental work such as field sampling, online detection, process control, etc. At present, the micro-total analysis system has had a great influence in the field of analytical ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N13/02
Inventor 林金明刘江疆
Owner TSINGHUA UNIV
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