Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Drop pills of amlodipine maleate and preparation method thereof

A kind of technology of amlodipine maleate and maleic acid, which is applied in the fields of medicines with special dosage forms, medicines for the treatment of hypertension and angina pectoris, and medicines

Inactive Publication Date: 2009-06-10
TIANNIAN PHARMA HARBIN
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently only tablets and capsules are used clinically

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drop pills of amlodipine maleate and preparation method thereof
  • Drop pills of amlodipine maleate and preparation method thereof
  • Drop pills of amlodipine maleate and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

specific Embodiment approach 1

[0071] (1) material preparation

[0072] According to the active ingredient of the drug is amlodipine maleate, the matrix is ​​polyethylene glycol-6000, stearic acid, sodium stearate, glycerin gelatin, poloxamer, polyoxyl 40 stearate, shellac, Any one of polyoxyethylene monostearate, polyether, sodium carboxymethyl starch or sodium lauryl sulfate pharmaceutical excipients or a mixture of two or more of them in any proportion, ammonium maleate The ratio of lodipine to the matrix is ​​1:2-10 in g or Kg; according to the composition of the membrane material, it is hypromellose 1.0-1.2g, titanium dioxide 0.8-1.0g, talcum powder 1.0 -1.2g, iron oxide yellow 0.10-0.15g, polysorbate-800.4-0.5g plus 80% ethanol to 50ml ratio to prepare raw materials;

[0073] (2) Preparation of dropping pills

[0074] a. Pass the raw materials through a 100-120 mesh sieve, weigh polyethylene glycol-6000 and poloxamer in proportion, heat and melt them in a water bath at 80°C, cool to 65°C and add the...

specific Embodiment approach 2

[0080] (1) material preparation

[0081] Containing amlodipine maleate 6.42g, polyethylene glycol-600035g, poloxamer 6g in the drop pill that every 1000 pills, every pill weight is 47.5mg Ratio, prepare raw and auxiliary materials; According to every 1000 pills, every Dropping pills with a pill weight of 47.5mg require 1.0g of hypromellose, 0.8g of titanium dioxide, 1.0g of talcum powder, 0.15g of iron oxide yellow, 0.4g of polysorbate-800.4g, and 80% ethanol to 50ml. Membrane material;

[0082] (2) Preparation of dropping pills

[0083] a. Pass the raw materials through a 100-120 mesh sieve, weigh polyethylene glycol-6000 and poloxamer in proportion, heat and melt them in a water bath at 80°C, cool to 65°C and add the prescribed amount of ammonia maleate Clodipine, heat and stir at 60°C until uniform.

[0084] b. Keep warm at 60°C. After adjusting the temperature of the cooling liquid, adjust the weight of the pellets to reach the specified weight. Drop them into the simet...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
melting pointaaaaaaaaaa
Login to View More

Abstract

The invention relates to a maleic acid amiloride horizotnal ball and relative preparation, wherein it is formed by active maleic acid amiloride horizontal and relative base; the active component is the maleic acid amiloride horizontal; the base is the carbowax 1500-20000, geoceric acid, sodium stearate, dodecyl sodium sulfate, etc; the ratio between the maleic acid amiloride horizontal and said base is 1:2-10 as g or kg; and the invention also comprises film material whose components are hydroxypropylmethylcellulose at 1.0-1.2g, titania at 0.8-1.0g, talcum powder at 1.0-1.2g, iron oxide yellow at 0.10-0.15g, sorbate-80 at 0.4-0.5g, and 80% alcohol to be 50ml. The invention has simple operation, low cost and high effect.

Description

(1) Technical field [0001] The invention relates to a medicine, specifically a medicine for treating hypertension and angina pectoris, especially a medicine with a special dosage form. The present invention also relates to the preparation method of the medicine in this special dosage form. (2) Background technology [0002] Amlodipine, as a drug for the treatment of hypertension and angina pectoris, can be used alone or in combination with other drugs such as β-blockers or thiazide diuretics or nitrates. Amlodipine offers a broad safety profile for patients. No effect on heart rate; no effect on cardiac conduction; no effect on myocardial contractility at clinical doses in hemodynamic studies; no adverse effect on metabolic parameters (such as blood lipids, plasma insulin, blood glucose levels, or insulin sensitivity); and others Commonly used drugs have no interaction. Amlodipine is well tolerated, and the incidence of adverse reactions is less than that of nifedipine an...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4422A61K9/20A61P9/10A61P9/12
Inventor 赵伟庆柳志强翟斌崔卫东
Owner TIANNIAN PHARMA HARBIN
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com