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Effervescent tablet containing cefixime and its preparing method

A technology for cefixime and effervescent tablets, which is applied in the field of effervescent tablets containing cefixime and its preparation, can solve the problems of difficulty in uniform dispersion and difficulty, and achieves fast onset speed, high blood drug concentration, and easy storage and storage. carry effect

Inactive Publication Date: 2008-09-10
CHINA PHARM UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Tablets, capsules, and dispersible tablets all have a certain volume and need to be swallowed by patients with water, which is difficult for children, the elderly, and patients who cannot swallow solid medicaments; while dry suspensions and granules are both in use. Need to add water to stir, otherwise it will be difficult to disperse evenly

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Cefixime 50g

[0032] Tartaric acid 150g

[0033] Sodium bicarbonate 100g

[0034] Cane sugar 170g

[0035] 5% PVP aqueous solution 5g

[0036] PEG6000 10g

[0037] Aspartame 15g

[0038] Orange flavor 10g

[0039] Place 50 grams of cefixime, sodium bicarbonate and 70 grams of sucrose in a container and mix for 30 minutes. While adding 5% PVP aqueous solution, pass through a 20-mesh sieve, and dry at 40 degrees for 45 minutes. In addition, place tartaric acid and 100 grams of sucrose in the container. Mix in the medium for 30 minutes, pass through a 20-mesh sieve while adding 5% PVP aqueous solution, and dry at 50 degrees for 40 minutes. The two parts of granules, aspartame, orange flavor and PEG6000 were mixed for 10 minutes, and transferred to a tablet press equipped with a dimpled punch with a diameter of 11 mm, and compressed into 1000 tablets.

[0040] Take 1 cefixime effervescent tablet prepared according to the above example 1, put it in a 250ml beaker. The beaker is...

Embodiment 2

[0042] Cefixime 100g

[0043] Tartaric acid 130g

[0044] Sodium bicarbonate 100g

[0045] Cane sugar 170g

[0046] PEG6000 5g

[0047] Acesulfame potassium 15g

[0048] Orange flavor 10g

[0049] Place cefixime, tartaric acid, sodium bicarbonate, sucrose, orange flavor, and aspartame in a container and mix for 30 minutes, transfer to a dry granulator for granulation, add PEG6000 and mix for 10 minutes, then transfer to a On the 11mm shallow concave punching tablet press, it is pressed into 1000 tablets.

[0050] Take 1 cefixime effervescent tablet prepared according to the above example 2 and put it in a 250ml beaker. The beaker contains 200ml water and the water temperature is 24 degrees. It is found that many bubbles are released. The effervescent tablet effervesce within 2 minutes. The solution is complete. When the gas around the tablets or fragments stops overflowing, the tablets are evenly dispersed in the water, and no aggregated particles remain. The pH of the resulting a...

Embodiment 3

[0052] Cefixime 50g

[0053] Tartaric acid 100g

[0054] Potassium hydrogen tartrate 40g

[0055] Sodium bicarbonate 100g

[0056] Sodium carbonate 20g

[0057] Mannitol 200g

[0058] Peppermint flavor 6 g

[0059] Aspartame 10g

[0060] 5% PVP ethanol solution 50g

[0061] Sodium lauryl sulfate 10 g

[0062] Put cefixime, tartaric acid, potassium hydrogen tartrate, sodium bicarbonate, sodium carbonate, sucrose, and aspartame in a container and mix for 30 minutes. While adding 5% PVP ethanol solution, pass through a 20-mesh sieve and dry at 40 degrees. minute. The dry granules, peppermint flavor and PEG6000 were mixed for 10 minutes, transferred to a tablet press equipped with a 12mm diameter dimple punch, and compressed into 1000 tablets.

[0063] Take 1 cefixime effervescent tablet prepared according to the above example 3 and place it in a 250ml beaker. The beaker is filled with 200ml water and the water temperature is 22 degrees. It is found that many bubbles are released. The...

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PUM

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Abstract

The present invention relates to an effervescent tablet containing cefixime and its preparation method. It contains 25-400 mg of cefixime and pharmaceutically-acceptable acid-dbase pair. Besides, the pharmaceutically-acceptable filling agent, adhesive, disintegrating agent, lubricating agent, sweetener and corrective also can be added according to the requirements.

Description

Technical field [0001] The invention relates to the technical field of pharmaceutical preparations, in particular to an effervescent tablet containing cefixime and a preparation method. Background technique [0002] Cefixime is a third-generation oral cephalosporin, which is clinically suitable for acute attacks of pharyngitis, tonsillitis, acute bronchitis and chronic bronchitis caused by sensitive bacteria, otitis media, urinary tract infection, simple gonorrhea (cervicitis or urethritis) ) And other treatments. [0003] According to the American Physician’s Desk Reference (PDR57) version, after oral administration of cefixime tablets and dry suspension, the absolute bioavailability is 40%-50%, and the peak plasma concentration time after oral administration is 2-6 hours. The bioavailability of cefixime solid preparations is low, and the onset of action is slow. [0004] The current clinical application dosage forms of cefixime include tablets, capsules, dry suspensions, granul...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/546A61K9/20A61K9/46A61P31/04A61P11/00A61P13/00A61P15/00A61P27/16
Inventor 张建军高缘
Owner CHINA PHARM UNIV
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