Drop pills of vepeside and preparation process thereof

A technology of etoposide dropping pills and etoposide, which can be applied in the directions of pill delivery, medical preparations containing active ingredients, organic active ingredients, etc., and can solve the problems of low bioavailability and the like

Inactive Publication Date: 2008-09-03
BEIJING ZHENDONG GUANGMING PHARMA RES INST
View PDF14 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The object of the present invention is to provide a kind of etoposide oral dripping pills and preparation method thereof, to increase the clinical medicinal dosage form, overcome the shortcoming of soft capsules with poor solubility and low bioavailability, and give full play to the fast absorption and bioavailability of drop pills. High dosage form advantage, to improve bioavailability, exert quick-acting therapeutic effect, reduce toxic and side effects

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Drop pills of vepeside and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0015] The present invention adopts the following preparation method: take the pharmaceutical adjuvant according to the formula quantity, which can also add other pharmaceutical adjuvants such as Tween-80, CMS-Na, etc. that help the drug release in the dripping pill, heat and melt, add The etoposide in the formula quantity is fully stirred to make it melt completely and disperse evenly to obtain a molten liquid; or weigh the etoposide according to the formula quantity, add an appropriate amount of cosolvent, dissolve it with slight heat, and then add the medicine in the formula quantity Use the auxiliary agent molten liquid, stir and mix evenly, evaporate the auxiliary solvent, and disperse evenly to prepare the molten liquid; put the molten liquid in the liquid storage cylinder of the dropping pill machine, keep it warm, and drop it at a certain dropping speed at an appropriate temperature In the condensate, condense into pills, collect the dripping pills, remove the coolant, ...

Embodiment 1

[0037] Prescription (Specification: 10mg / pill)

[0038] Etoposide 10g

[0039] Macrogol 4000 30g

[0040] A total of 1000 capsules

[0041] Preparation:

[0042] Weigh according to the weight ratio of each component, heat polyethylene glycol 4000 to make it melt, add etoposide fine powder, stir continuously to make it all melt, put it in the liquid storage bottle of the dropping pill machine, and keep it warm at 80°C 30 minutes to serve. Adjust the drop distance to 3cm, and drop it into the liquid paraffin condensate containing methyl silicone oil at a constant speed of 50 drops / min. The temperature of the upper 20cm of the condensate is 20±2°C, and the temperature of the lower 30cm is 0±1°C. Collect the dripping pills, remove the condensing agent on the surface of the dropping pills, dry, and select the pills to obtain the finished product.

[0043] Determination of dissolution time: According to the 3rd method of appendix X11A of the Chinese Pharmacopoeia 2000 edition, ...

Embodiment 2

[0048] Prescription (Specification: 10mg / pill)

[0049] Etoposide 10g

[0050] Macrogol 6000 30g

[0051] Tween-80 0.25g

[0052] A total of 1000 capsules

[0053] Preparation:

[0054] Weigh according to the weight ratio of each component, heat polyethylene glycol 6000 to melt, add etoposide fine powder and Tween-80, stir continuously to melt all, put in the liquid storage bottle of the dropping pill machine medium, 86°C for 30 minutes and set aside. Adjust the drop distance to 4cm, and drop it into the liquid paraffin condensate at a constant rate of 60 drops / min. The temperature of the upper 20cm of the condensate is 23±3°C, and the temperature of the lower 30cm is 5±1°C. Collect the dripping pills, remove the condensing agent on the surface of the dropping pills, dry, and select the pills to obtain the finished product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to an Etoposide drop pill preparation and its preparing process, wherein the preparation is prepared from Etoposide and auxiliary constituents including medicinal adjuvant through the steps of charging Etoposide into medicinal adjuvant, homogenizing, then condensing and drying.

Description

technical field [0001] The invention relates to an etoposide dropping pill and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. technical background [0002] Etoposide, also known as etoposide, etoposide, and etoposide, is a semi-synthetic derivative of epipodophyllin, namely 4'-desmethyl epipodophyllotoxin 9-(4 , 6-O-methylene-β-D-glucopyranoside). It is an important anticancer drug commonly used in clinic at present. Cell tumor and children's striated muscle have a significant curative effect, and it can also be used in combination with other drugs to treat ovarian cancer, gastric cancer and liver cancer. In particular, it has been approved for the treatment of small cell lung cancer and testicular cancer in the United States. It is a cycle-specific cytotoxic drug, which mainly acts on the S phase of the cell cycle, making cells unable to undergo mitosis. Its mechanism of action is mainly related to inhibition of topoisomer...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7048A61K9/20A61P35/00
Inventor 王智民仝燕
Owner BEIJING ZHENDONG GUANGMING PHARMA RES INST
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap