The invention relates to a ball point pen refill automatic marking inspection device. The ball point pen refill automatic marking inspection device is characterized in that multiple axially same crankshafts not disposed in the same plane are utilized, one of these crankshafts is an driving crankshaft, the driving crankshaft drives a pen refill in a marking unit to perform circle drawing motion, at the same time, the marking unit drives other driven crankshafts to rotate synchronously, and the pen refill in the marking unit is enabled to maintain at a stable state in the circle drawing process, such that the pen refill can be prevented from damage, ink in an ink tube of the pen refill can also be prevented from being interrupted, and secondary quality accidents are avoided. During operation, a paper delivery wheel of a paper feeding unit rotates to drive paper to move, the marking unit drives the pen refill to draw a locus on the paper, an image acquisition unit acquires the locus, a master control unit, according to an image, determines whether line breaking, hollowing or single siding occur in the pen refill, and if the line breaking, the hollowing or the single siding are detected, the master control unit controls a rejection apparatus to reject the corresponding pen refill.