The invention discloses screen printing ink and an application process thereof. The screen printing ink consists of printing color ink and a curing agent, wherein the printing color ink is 100 parts by volume and the curing agent is 3-10 parts by volume; the curing agent consists of the following components by in parts by volume: 100 parts of acrylic baking paint, 40 parts of isophorone, 20 partsof cyclohexanone and 25 parts of butyl acetate; and the application process of the screen printing ink comprises the steps of configuration of the curing agent, configuration of the screen printing ink, screen printing, drying and curing, etc. The process is simple and the screen printing efficiency is high. The screen printing ink provided by the invention is added with a curing agent for improving adhesion and wear resistance, and the main composition of the curing agent is a mixture of acrylic baking paint, isophorone, cyclohexanone, butyl acetate and the like, and the acrylic baking painthas good adhesion, wear resistance and gloss retention, so that the adhesion and wear resistance of the whole screen printing ink are greatly improved, a printed pattern is very stable, cannot fall off, has strong wear resistance, and the product quality is greatly improved.