The invention discloses a symmetrical type full-interchange cross overpass with pedestrian-vehicle separation, which perfectly realizes pedestrian-vehicle separation without disturbance. For the humanized aspect of the overpass, non-motor vehicle lanes are designed at one layer of a horizontal plane so as to bring convenience for non-motor vehicles, pedestrians, the blind and the disabled sitting on wheelchairs; simultaneously, with the symmetrical type design, the trouble that drivers select a junction again for turning around or turning a corner when passing the overpass is avoided and the problem of going up the overpass easily but going down the overpass difficultly is solved. For the symmetrical type full-interchange cross overpass, the non-motor vehicle lanes, sidewalks and blind lanes are omitted, a layer is reduced, and the symmetrical type full-interchange cross overpass also can be used as a highway overpass. The symmetrical type full-interchange cross overpass has the characteristics that the designs of going straight, turning around, turning left and turning right in the four directions of east, south, west and north of motor vehicle lanes are consistent; the designs of the non-motor vehicle lanes, the sidewalks and the blind lanes in the four directions of southeast, southwest, northeast and northwest of the non-motor vehicle lanes are consistent; the humanized design of the non-motor vehicle lanes, the symmetrical easy-running design of the motor vehicle lanes and the attractiveness design are integrated together.