50 results about "Raf Kinase Inhibitor" patented technology
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Any substance that inhibits Raf Kinase, an enzyme active in signal transduction in the Ras pathway. Inhibition of Raf kinase may result in reduced cell proliferation and cell death.
The invention relates to Raf kinase inhibitor pentafluoridesulfur-based arylurea, and a preparation method and applications thereof. The structure of pentafluoridesulfur-based arylurea is represented by formula I, wherein Z, R1, R3, R2, m, and n are defined by the patent claims and the patent specification. Pntafluoride sulfur-based arylurea can be used as a Raf kinase inhibitor, possesses excellent stability, and can be used for preparing medicines used for preventing and / or treating Raf kinase induced diseases.
The invention relates to the field of pharmaceutical chemistry, in particular to a diaryl urea compound (A), wherein the definitions of R1-R13, Ar and X are shown in the specification. The invention also discloses a preparation method of the compounds of the general formula (A), medicinal compositions containing the compounds and medical application thereof, particularly application as the Raf kinase inhibitor.