38 results about "Odorant Receptor" patented technology

Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants. Methods of making deodorant compositions are also provided wherein a cross-adapting agent, alone or in combination with other such agents, are included in an amount effective to reduce perception of malodor.

The present invention relates to polypeptides capable of modulating odorant receptor activation. In particular, the present invention provides polypeptides (e.g., type 3 muscarinic actetylcholine receptor M3) capable of enhancing odorant receptor activation. The present invention further provides assays for the detection of ligands specific for various odorant receptors. Additionally, the present invention provides methods of screening for polypeptide polymorphisms and mutations associated with odorant receptor activation (e.g., polymorphisms and mutations associated with muscarinic actetylcholine receptor polypeptides (e.g., M1, M2 M3, M4, M5)), as well as methods of screening for therapeutic agents, ligands, and modulators of such proteins.

The present invention relates to the characterization of odorant receptors. In particular, the present invention relates to the OR7D4 proteins and nucleic acids encoding OR7D4 proteins and cell systems for screening for modulators of OR7D4 receptors. The present invention further provides assays for the detection of OR7D4 polymorphisms and mutations associated with altered olfactory sensation states, as well as methods of screening for therapeutic agents, ligands, and modulators of OR7D4 receptors.

The present invention relates to insect odorant receptor genes and methods for identifying odorant receptor genes. The invention provides nucleotide sequences of insect odorant receptor genes Or83b, amino acid sequences of their encoded proteins (including peptides or polypeptides), and related products and methods. The nucleic acids of the invention may be operatively linked to promoter sequences and transformed into host cells. Methods of production of an Or83b odorant receptor protein (e.g., by recombinant means), and derivatives and analogs thereof, are provided. Antibodies to an Or83b odorant receptor protein, and derivatives and analogs thereof, are provided. Methods for identifying molecules that bind or modulate the activity of these Or83b odorant receptor genes are provided. Molecules found to bind or modulate the activity of Or83b genes may be formulated into pest control agents by providing a carrier. In a preferred embodiment, molecules that bind or modulate the activity of an Or83b gene form one species but not others is desired. Methods to modify the insect behavior by modifying an insect Or83b odorant are also provided.

The present invention provides an insect odorant receptor co-receptor that exhibits excellent detection sensitivity of odorants when bound with an odorant receptor to form an odorant receptor complex.This odorant receptor co-receptor is provided with the following first amino acid sequence and second amino acid sequence which follows the amino acid residue furthest on the carboxyl-terminal side of the first amino acid sequence: (1) a first amino acid sequence which is a partial amino acid sequence of an odorant receptor co-receptor of a first insect or a variant of the receptor, and which isan amino acid sequence that is continuous from the amino-terminal of the first insect odorant receptor co-receptor or the variant thereof to any amino acid residue positioned in the range of 20 aminoacid residues before and after the amino acid residue furthest on the carboxyl-terminal side in the fourth transmembrane domain; and (2) a second amino acid sequence which is a partial amino acid sequence of an odorant receptor co-receptor of a second insect of a different variety than the first insect or a variant of the receptor, and which, in an alignment analysis of the amino acid sequence ofthe first insect odorant receptor co-receptor or the variant thereof and the amino acid sequence of the second insect odorant receptor co-receptor or the variant thereof, is an amino acid sequence that is continuous from one carboxyl-terminal-side amino acid residue, said residue being in a position in the second insect odorant receptor co-receptor or the variant thereof that corresponds to the amino acid residue furthest on the carboxyl-terminal side of the first amino acid sequence, to the carboxyl-terminal of the second insect odorant receptor co-receptor or the variant thereof.

The invention provides a sensor device comprising an insect odorant receptor complex, comprising an OrX and an Orco, in electrical communication with a substrate, wherein the sensor device is configured to detect a change in an electrical characteristic of the substrate. The invention also provides sensor device component comprising an insect odorant receptor complex, comprising an OrX and an Orco, in electrical communication with a substrate. The invention also provides methods for manufacture and use of the sensor device and sensor device component. The invention also provides methods of useof the sensor to detect an analyte.

This invention provides novel libraries of olfactory receptor odorant / ligand-binding domains and methods of making and using them. The invention also provides libraries of vectors and cells comprising these nucleic acid constructs. The compositions and methods of the invention are used to identify novel ligand-binding domains for olfactory neuron odorant receptors and their ligands. Thus, the compositions and methods of the invention can be used to generate novel odorants, to screen for toxic odorants, or to manipulate an animal's olfactory response.

The invention provides a sensor device comprising an insect odorant receptor (OrX) in electrical communication with a substrate, wherein the sensor device is configured to detect a change in an electrical characteristic of the substrate. The invention also provides sensor device component comprising an insect odorant receptor (OrX) in electrical communication with a substrate. The invention also provides methods for manufacture and use of the sensor device and sensor device component. The invention also provides methods of use of the sensor to detect an analyte.

This invention provides an isolated nucleic acid molecule encoding an insect odorant receptor. This invention provides a nucleic acid molecule of at least 12 nucleotides capable of specifically hybridizing with the nucleic acid molecule encoding an insect odorant receptor. This invention also provides a purified, insect odorant receptor. This invention provides an antibody capable of specifically binding to an insect odorant receptor. This invention provides a method for identifying cDNA inserts encoding an insect odorant receptors. This invention provides a method of identifying a compound capable of specifically bind to an insect odorant receptor. This invention also provides a method of identifying a compound capable of activating the activity of an insect odorant receptor.

The present invention relates to a diagnostic kit for metabolic diseases selected from the group consisting of obesity, dyslipidemia, fatty liver, and insulin resistance syndrome, and a method for screening a therapeutic composition for said diseases. The invention provides a large number of new gene targets for metabolic diseases such as obesity and the like, thereby enabling a more reliable diagnosis of genes such as obesity and the like and the use in the screening of a therapeutic candidate material based on the new gene targets.

The present invention relates to an odorant receptor based odorant sensor system and related methods. In particular, systems and methods are provided permitting detection and discrimination of an odorant molecule in a vapor / gaseous phase using a panel of odorant receptors expressed in heterologous cells.