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Methods of reducing the perception of body odors with olfactory adaptation and cross-adapting agents

a technology of olfactory adaptation and body odor, applied in the field of human olfactory adaptation, to achieve the effect of reducing the magnitude of stress-derived axillary odor intensity

Inactive Publication Date: 2007-01-25
MONELL CHEM SENSES CENT
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0011] The present invention also provides methods of reducing perception of body odor or malodor comprising administering a deodorant composition that includes a cross-adapting agent alone or in combination with other such agents in an amount effective to reduce perception of male and female body odor. The present invention also provides methods of reducing perceived male body odor or malodor, as well as methods of reducing perceived female body odor comprising administering a deodorant composition comprising an amount of cross-adapting agent effective to reduce perception of a gender specific body odor.
[0013] In a further embodiment of the present invention, methods are provided for making a deodorant composition comprising providing a cross-adapting agent alone or in combination with other such agents in an amount effective to reduce perception of malodor.

Problems solved by technology

Such adaptation can result, at least in part, from peripheral events, such as fatigue of the receptor.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Cross-Adaptation of Male Stress-Derived Axillary Odor

[0047] Sixteen (16) individuals (8 of each gender) served on an odor panel. Subjects ranged in age from 22 to 55 years (mean 32.7±10.6 s.d.), were not pregnant (by verbal report), and were all non-smokers. All panel members were screened for adequate use of magnitude estimation (some people have difficulties maintaining a ratio scale, i.e., when an odorant is half as strong as the previous, these people fail to provide a number that is half the previous estimate) and further trained in its use during 2-3 training sessions. All 16 subjects were tested with samples of male malodor compared to each of the potential cross-adapting agents.

[0048] Male stress-derived axillary odor, produced as described above, was presented in glass vials for the subjects to sniff once to obtain the first baseline of perceived intensity using magnitude estimation. Subsequently, subjects continuously sniffed from an adapting jar that contained only dilu...

example 2

Deodorant Compositions for Men

[0057] Data from the cross-adaptation study was compiled and evaluated based on the effect each test material had on the magnitude of the stress-derived axillary odor intensity. Agents that produced the highest reduction in the stress-derived axillary odor intensity were labeled as “best” in Table 2. Agents that showed a moderate reduction were labeled as “good” and agent that had the least effect on reducing the magnitude of the stress-derived axillary odor intensity were labeled as “poor.” A product can be constructed in a way to include as many “best” or “good” materials as desired and provide consumer acceptable hedonics.

TABLE 2Magnitude of Reduction of Intensityof Male Stress-Derived Odor (MSDO)MSDOMSDOMalesFemalesAgrumexgoodpoorC14 AldehydegoodpoorAmbrettolidepoorpoorAnisyl Aldehyde——Calone 1951——l-CarvonebestbestCEDRAMBER ®goodpoorCitronellol 950goodgoodCitrylalbestgoodCLARITONE ®bestbestcpd Suprapoorpoorα-DamasconepoorpoorΔ-DamasconebestgoodD...

example 3

Cross-Adaptation of Female Stress-Derived Axillary Odor

[0062] A separate panel of 24 subjects (12 males and 12 females) tested samples of female stress-derived axillary odor with potential cross-adapting agents, some of which were not included in Example 1 above. Some of the subjects assessing the effectiveness of cross-adaptation of male stress-derived axillary odor were also used in the experiment with female secretions. However, these two experiments were treated as independent events. All panel members were screened for adequate use of magnitude estimation and further trained in its use during two to three training sessions. Subjects were tested with samples of female stress-derived axillary odor, prepared as described above for male stress-derived axillary odor, and compared to each of the potential cross-adapting agents, as set forth in Example 1 above. No subject was tested with all potential cross-adapting agents.

[0063] An array of adapting agents was tested for cross-adap...

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Abstract

Deodorant compositions are disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of malodor. Deodorant compositions are also disclosed comprising a cross-adapting agent, alone or in combination with other such agents, in an amount effective to reduce perception of gender-specific malodor. The methods feature reducing perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to reduce perception of such odor. Other methods feature blocking perceived body odor comprising administering a deodorant composition wherein the composition comprises an amount of cross-adapting agent effective to occupy an odorant receptor site, thereby blocking interaction of the site with other odorants. Methods of making deodorant compositions are also provided wherein a cross-adapting agent, alone or in combination with other such agents, are included in an amount effective to reduce perception of malodor.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] This application is a divisional of application Ser. No. 10 / 342,626, filed Jan. 15, 2003, and claims benefit of U.S. Provisional Application No. 60 / 349,111, filed Jan. 16, 2002 and U.S. Provisional Application No. 60 / 390,313, filed Jun. 21, 2002, each of which is hereby incorporated by reference in its entirety.FIELD OF THE INVENTION [0002] The present invention relates to human olfactory adaptation, including human olfactory cross-adaptation, and to methods, cross-adapting agents and compositions to reduce the perception of body odors, including gender-specific body odors. BACKGROUND OF THE INVENTION [0003] Olfactory adaptation is a phenomenon that is generally understood to include a decrease in sensitivity to an odorant that results from exposure to that odorant. Such adaptation can result, at least in part, from peripheral events, such as fatigue of the receptor. [0004] Cross-adaptation is a phenomenon that is generally understood t...

Claims

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Application Information

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IPC IPC(8): A61K8/28A61K8/33A61K8/34A61K8/35A61K8/37A61K8/49A61Q15/00
CPCA61K8/33A61K8/34A61K8/35A61Q15/00A61K8/4973A61K8/498A61K8/37
Inventor PRETI, GEORGEWYSOCKI, CHARLES J.SMITH, LESLIE C.MCDERMOTT, KEITH J.
Owner MONELL CHEM SENSES CENT
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