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Biosensor device and methods

A sensor device and sensor technology, applied in chemical instruments and methods, measuring devices, biomaterial analysis, etc., can solve the problems of no commercial products, poor sensitivity and specificity, and lack of very high mobility for user training

Pending Publication Date: 2021-02-26
THE NEW ZEALAND INST FOR PLANT & FOOD RES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Commercially available portable volatile sensing technologies are limited to electronic / chemical electronic noses whose performance is significantly inferior to insect olfactory systems in terms of sensitivity and specificity
Furthermore, to the applicant's knowledge, there are no commercial products based on the insect OR-based systems described above
Other technologies such as ion mobility spectrometers and mass spectrometers offer improved sensitivity and specificity over electronic noses, but are very expensive to purchase, require extensive user training and are not very mobile

Method used

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  • Biosensor device and methods
  • Biosensor device and methods
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Embodiment Construction

[0414] Applicants' invention successfully combines the olfactory capabilities of insect odorant receptors with a convenient sensor format for the first time.

[0415] In addition to the increased convenience, the sensor device of the present invention also surprisingly provides a significant improvement in detection sensitivity relative to previous assay systems based on the use of insect ORs.

[0416] insect odorant receptor complex

[0417] Insect odorant receptors (ORs) are members of a novel family of seven transmembrane proteins that form ligand-gated non-selective cation channels. The highly conserved insect odorant coreceptors (Orco) are thought to form active channels in vivo with odorant specificity conferred by a set of ligand-binding subunits (OrX), such as figure 1 shown in .

[0418] Preferably, the detection is specific for the analyte.

[0419] In vivo, the N-terminus of the insect OrX protein is located in the cytoplasm, while the C-terminus is located outsi...

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Abstract

The invention provides a sensor device comprising an insect odorant receptor complex, comprising an OrX and an Orco, in electrical communication with a substrate, wherein the sensor device is configured to detect a change in an electrical characteristic of the substrate. The invention also provides sensor device component comprising an insect odorant receptor complex, comprising an OrX and an Orco, in electrical communication with a substrate. The invention also provides methods for manufacture and use of the sensor device and sensor device component. The invention also provides methods of useof the sensor to detect an analyte.

Description

technical field [0001] The present invention relates to sensors and methods for detecting analytes. Background technique [0002] Real-time detection of analytes such as volatile organic compounds (VOCs) and soluble organic chemicals is a key challenge for health and environmental monitoring as well as food safety and water quality, and there is a strong drive to develop affordable and Fast analyte sensor. [0003] Convenient, sensitive and specific analyte sensors will have diverse applications including monitoring and food quality / safety (flavoring, ripening, contamination and spoilage), biosecurity (pests and diseases), environmental monitoring (harmful pollutants), Analytes relevant for medical diagnostics (e.g. respiratory diagnostics) and security (illegal compounds and explosives). [0004] Insect olfactory receptors (OR) can distinguish a wide range of natural and synthetic chemicals, including VOCs. Insect ORs act as heteromeric ligand-gated cation channels ( fi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/414C07K14/705B82Y15/00
CPCG01N33/5438G01N33/566G01N33/5432G01N27/4145G01N2333/43573G01N27/026G01N21/554C07K14/705G01N2291/0255G01N2291/0256G01N29/022B82Y30/00C07K14/43563G01N33/6872G01N2291/0426C07K14/43581C07K2319/21B82Y15/00B82Y40/00G01N2291/025G01N27/414
Inventor A·V·克拉里塞克C·卡拉和N·艾代米尔J·特拉凡斯-赛迪克R·卡德加N·O·V·普兰克T·穆鲁加萨斯
Owner THE NEW ZEALAND INST FOR PLANT & FOOD RES LTD
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