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Sensor device and methods

A sensor device and sensor technology, applied in the direction of chemical instruments and methods, measuring devices, nanotechnology for sensing, etc., can solve the problems of no very high mobility, no commercial products, expensive purchases, etc.

Active Publication Date: 2019-10-11
THE NEW ZEALAND INST FOR PLANT & FOOD RES LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Furthermore, to the applicant's knowledge, there are no commercial products based on the insect OR-based systems described above
Other technologies such as ion mobility spectrometers and mass spectrometers offer improved sensitivity and specificity relative to electronic noses, but are very expensive to purchase, require extensive user training and are not very mobile

Method used

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Embodiment Construction

[0263] Applicants' invention successfully combines the olfactory capabilities of insect odorant receptors (OrX) with a convenient sensor format for the first time.

[0264] In addition to the increased convenience, the sensor device of the present invention surprisingly provides a very significant improvement in detection sensitivity relative to previous assay systems based on the use of insect ORs.

[0265] Furthermore, the sensor of the present invention is surprisingly able to function in the absence of the odorant coreceptor (Orco), whereas all previous assay systems based on the use of insect ORs relied on including both OrX and Orco.

[0266] insect odorant receptor complex

[0267] Insect odorant receptors (ORs) are members of a novel family of seven-transmembrane proteins that form ligand-gated nonselective cation channels. The highly conserved insect odorant coreceptor (Orco) is thought to form active channels in vivo with odorant specificity conferred by a set of li...

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Abstract

The invention provides a sensor device comprising an insect odorant receptor (OrX) in electrical communication with a substrate, wherein the sensor device is configured to detect a change in an electrical characteristic of the substrate. The invention also provides sensor device component comprising an insect odorant receptor (OrX) in electrical communication with a substrate. The invention also provides methods for manufacture and use of the sensor device and sensor device component. The invention also provides methods of use of the sensor to detect an analyte.

Description

technical field [0001] The present invention relates to sensors and methods for detecting analytes. Background technique [0002] Real-time detection of analytes such as volatile organic compounds (VOCs) and soluble organic chemicals is a key challenge for health and environmental monitoring as well as food safety and water quality, and there is a strong drive to develop affordable and fast analyte sensor. [0003] Convenient, sensitive and specific analyte sensors will have a variety of applications including monitoring and food quality / safety (flavorings, ripening, contamination and spoilage), biosecurity (pest and disease), environmental monitoring (harmful contaminants), Analytes related to medical diagnostics (eg respiratory diagnostics) and security (illicit compounds and explosives). [0004] Insect olfactory receptors (ORs) can discriminate between a wide range of natural and synthetic chemicals, including VOCs. The insect OR acts as a heteromeric ligand-gated cat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N27/414C07K14/705B82Y15/00
CPCB82Y15/00C07K14/705G01N27/4145G01N27/4146G01N27/414G01N27/124G01N27/122G01N33/5438
Inventor T·穆鲁加萨斯R·卡德加A·V·克拉里塞克C·卡拉和H·Y·郑N·O·V·普兰克J·特拉凡斯-赛迪克N·艾代米尔
Owner THE NEW ZEALAND INST FOR PLANT & FOOD RES LTD
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