73 results about "Disposable bioreactors" patented technology

The present invention is in the field of cell bioreactors, and specifically in the field of disposable bioreactors.

A port for use with a bioreactor vessel comprising:i) a base member comprising a hollow tubular portion and a base plate configured to be sealingly affixed to a hole in the wall of a bioreactor vesselii) a hollow, generally tubular bushing member for containing electrical, optical, microfluidic and / or chemical monitoring components which bushing member fits inside the bore of the tubular portion of the base member, both the base member and bushing member providing access to the contents of a bioreactor by;iii) a monitoring assembly inserted into the bushing member which assembly comprises means for providing incoming optical and / or electrical signals and means for collecting and transmitting measurement signals resulting from the interaction of incoming optical and / or electrical signals with the contents of a bioreactor; andiv) a cover which maintains the position and alignment of components ii) and iii) relative to the base member.

A sensor protector is intended to reduce the sensitivity of the optical sensor (4) to radiation products which, for example, are formed during sterilization with gamma radiation and to ensure simple and cost-effective manufacture. The sensor protector includes an upper part (1), a lower part (3) and an optical sensor (4). The optical sensor (4) situated on the lower part is positionable in an offset manner with respect to an opening (2) situated in the upper part and movable by means of displacement toward the opening (2) of the upper part (1). The sensor protector is suitable for use in containers and laboratory products that are sterilized by gamma radiation, for example disposable bioreactors.

In one embodiment, a disposable bioreactor including a headplate and a stirrer. The headplate has at least one inlet port aperture and one outlet port aperture formed therein and is adapted to couple sealingly with a bag capable of receiving a culture medium. The stirrer is coupled to and extends from the headplate and is adapted to stir the culture medium when the headplate is coupled to the bag. The bioreactor is adapted to fit within the upper opening of the stand of an existing conventional glass bioreactor, so that the bag is suspended within the vessel.

The invention relates to a potentiometric probe for measuring a measurement variable of a medium to be measured contained in a tank, in particular a disposable bioreactor, comprising: a housing (1) comprising a first chamber (5) in which a reference half cell is formed, said cell being connected to a medium surrounding the housing (1) by means of an electrolytic contact point (7) disposed in a wall of the housing (1), wherein the housing (1) comprises a second chamber (9) in which a measurement half cell is formed, wherein the second chamber (9) is closed on one side by a measurement membrane (11), so that a surface of the measurement membrane facing away from the second chamber (9) is in contact with the medium surrounding the housing (1), and wherein the measurement half cell comprises a longitudinal extension between the measurement membrane (11) and a closure element (18); bounding the measurement half cell on a side opposite the measurement membrane (11), characterized in that a quotient of a distance (h) of the measurement membrane (11) from the closure element (18) and an outer diameter (rA) of the housing (1) is less than 5, in particular less than 2.