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35 results about "Calcium oxalate calculus" patented technology
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Organic acids as agents to dissolve calcium minerals in pathological calcification and uses thereof
ActiveUS20150297545A1Good effectInhibition effectBiocideOrganic chemistryCalcium oxalate calculusOrganic acid
In an embodiment of the present disclosure, there is provided a composition for dissolving calcium oxalate crystals thereby inhibiting / preventing further growth of crystals. In some embodiments, such a composition comprises at least one stereoisomer of hydroxycitrate, a derivative of the organic acid citrate. Such a method comprises administering to the subject an effective amount of the aforementioned composition. In another embodiment, the present disclosure pertains to a method of treating kidney stone disorder. Such a method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition. In yet another embodiment, the present disclosure relates to a method of treating calcium oxalate stone disease. In an embodiment, the method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition.
Owner:UNIV HOUSTON SYST
Calcium oxalate crystallization inhibitor and uses thereof
InactiveCN101433549ASimple preparation processOrganic chemistryUrinary disorderCalcium oxalate calculusVitamin C
The invention discloses calcium oxalate crystallization inhibitor and application thereof. The inhibitor is prepared by nano selenium which is obtained by mixed reaction of selenite solution and vitamin C solution according to certain proportion. Preferably, the selenite is sodium selenite or selenium dioxide, and the vitamin C is reduced vitamin C. The invention uses the nano selenium to prepare the calcium oxalate crystallization inhibitor for the first time; and the obtained inhibitor can effectively inhibit growth and gather of calcium oxalate, and can be used for preparing calculus inhibiting medicament of the calcium oxalate.
Owner:JINAN UNIVERSITY
Application of hydrogen to preparation of medicament and health-care beverage for preventing kidney stones
InactiveCN102462694ALow priceImprove stabilityMilk preparationInorganic active ingredientsCalcium oxalate calculusHydrogen
The invention provides an application of hydrogen to preparation of a medicament and a health-care beverage for preventing kidney stones. Hydrogen is prepared into an oral preparation or beverage; after the oral preparation or the beverage is taken, oxalic acid output can be effectively lowered, and urine citric acid concentration is increased; and meanwhile, SOD (Super Oxygen Dehydrogenises) activity can be increased, the generation of MDA (Methane Dicarboxylic Aldehyde) and formation of calcium oxalate stones are reduced, and the reoccurrence of calcium oxalate stones is prevented.
Owner:上海交通大学医学院附属第三人民医院
Preparation method of dry powder and fungus powder containing Tricholoma lobayense Heim oxalate decarboxylase
ActiveCN102697040AIncrease vitalityEfficient degradationPowder deliveryMicroorganism based processesIntestinal structureCalcium oxalate calculus
The invention discloses a preparation method of dry powder and fungus powder containing Tricholoma lobayense Heim oxalate decarboxylase and relates to the field of degradation of oxalate in stomachs and intestines of human bodies or animal bodies. The preparation method comprises the following steps of: using Tricholoma lobayense Heim or sibling fungi thereof as raw materials, culturing thalli by adopting a liquid fermentation method, regulating pH (potential of hydrogen) of fermentation solution to 2.0-5.0, inducing to produce oxalate decarboxylase, collection the fermentation solution and the thalli, crushing the thalli, conducting solid-liquid separation to respectively obtain liquid and solid containing the Tricholoma lobayense Heim oxalate decarboxylase, and respectively drying the obtained liquid and solid after separation to obtain the dry powder and the fungus powder containing the Tricholoma lobayense Heim oxalate decarboxylase. The dry powder and the fungus powder containing the Tricholoma lobayense Heim oxalate decarboxylase can be used for oxalic acid removal of food, beverage, feed and the like, can also be used as raw materials to prepare healthcare products or medicines, is suitable for oral taking, can effectively degrade oxalic acid and oxalate and can prevent or cure urine oxalic acid excess symptoms and calcium oxalate calculi.
Owner:WUHAN KANGFUDE BIOTECH CO LTD
Composition containing phytic acid, magnesium and polyphenols for the treatment or prevention of renal lithiasis
ActiveCN106535906AHydroxy compound active ingredientsUrinary disorderCalcium oxalate calculusFood supplement
The invention relates to a composition containing phytic acid or a phytate salt, magnesium in the form of salt, hydroxide or oxide and optionally at least one polyphenol. These compounds can be in the isolated form or form part of an enriched plant extract. The invention also relates to the use of this composition for the treatment of renal lithiasis, preferably calcium or oxocalcium, in the form of a drug, nutraceutical or functional food, or food supplement.
Owner:UNIV DE LAS ISLAS BALEARES
Organic acids as growth inhibitors of pathological calcification and uses thereof
In an embodiment of the present disclosure, there is provided a composition for inhibiting calcium oxalate crystal growth. In an embodiment of the present disclosure, there is provided a composition for inhibiting calcium phosphate crystal growth. In some embodiments, such a composition comprises at least one citrate derivative of an organic acid and at least one pharmaceutically acceptable carrier. In another embodiment, the present disclosure relates to a method of controlling calcium oxalate crystal growth in a subject in need thereof. Such a method comprises administering to the subject an effective amount of the aforementioned composition. In another embodiment, the present disclosure pertains to a method of treating kidney stone disorder. Such a method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition. In yet another embodiment, the present disclosure relates to a method of treating calcium oxalate stone disease. In an embodiment, the method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition.
Owner:UNIV HOUSTON SYST
Oxalic acid degrading bacterium NJODL1 and application thereof
ActiveCN102250800AImprove toleranceNo antibiotic resistanceMilk preparationBacteriaAntibiotic resistanceAntibiotic Y
The invention discloses an oxalic acid degrading bacterium NJODL1, which is classified and named as Lc.lactis subsp.lactis with the collection number CGMCC No.4582. A strain has the effects of degrading oxalic acid, regulating oxalate metabolism and preventing and controlling calcium oxalate calculus of pets. The oxalic acid degrading bacterium NJODL1 has high tolerance on acids and bile salts, does not have antibiotic resistance on most antibiotics, is safe for mice and can be colonized in dogs. By adopting NJODL1, the absorption of oxalic acid in foods by a gastrointestinal tract can be reduced, the content of oxalic acid in urea is lowered, and the incidence rate of calcium oxalate calculus of dogs is further lowered. Regardless of being prepared into a food or a medicament or yoghourtor acidified milk, the strain has high acid resistance, high bile salt resistance, the effects of remarkably lowering urea oxalic acid and preventing and controlling calcium oxalate calculus of pets,and contains safe enterococcus.
Owner:NANJING AGRICULTURAL UNIVERSITY
Composition for inhibiting or dissolving calcium oxalate stones as well as preparation method and application of composition
ActiveCN111419786AGrowth inhibitionNon-traumaticPeptide/protein ingredientsEnergy modified materialsOXALIC ACID DIHYDRATECalcium oxalate calculus
The invention relates to a composition for inhibiting or dissolving calcium oxalate stones as well as a preparation method and application of the composition. The composition comprises an immobilizedoxalate decarboxylase that can catalyze a decarboxylation reaction of oxalic acid or / and an oxalate, and the immobilized oxalate decarboxylase is prepared by immobilizing oxalate decarboxylase on a magnetic particle carrier. The composition provided by the invention has the function of inhibiting the growth of the calcium oxalate stones or dissolving the calcium oxalate stones, and has the advantages of mildness, good tolerance and high safety, and a patient has no trauma or pain when the composition is applied to treat kidney stones; and when the composition provided by the invention is applied to treat the calcium oxalate stones, the oxalate decarboxylase can be fixed in a renal pelvis by applying a magnetic field to continuously degrade oxalic acid in urine, so that the action time andefficiency of enzyme are increased, after the treatment is completed, the magnetic field is removed, and immobilized enzyme magnetic beads can be excreted with the urine; and after the composition isused in combination with drugs for regulating the pH of the urine, the effects of degrading the oxalic acid and dissolving the stones can be enhanced.
Owner:周定兰
Medicinal health agent for preventing and treating canine urinary calculi
InactiveCN101664439AGuaranteed normal generationInhibition formationHydroxy compound active ingredientsUrinary disorderEpitheliumMagnesium ammonium phosphate
The invention relates to a medicinal health agent for preventing and treating canine urinary calculi, which is characterized in that the agent is obtained by evenly mixing the following effective components in ratio by weight or unit: 10 to 40 mg of organic germanium, 1,000 to 6,000 mg of potassium citrate, 20,000 mg of lysimachia nummularia particles, 5,000 IU of vitamin A and 10 mg of vitamin B6, wherein the vitamin A maintains the integrity of urinary tract epithelium to realize the activity of crystallization inhibitor so as to inhibit crystallization; the organic germanium enhances the process of crystallization inhibition; lysimachia nummularia promotes urination, treats stranguria and plays a significant role in promoting urination and removing stones; meanwhile, the lysimachia nummularia has the function of resisting inflammation and bacteria, reduces urinary tract injury, inhibits urease-producing bacteria, and turns urine to be acidic after the lysimachia nummularia is metabolized in human bodies so as to inhibit the formation of magnesium ammonium phosphate stones; citric acid competes with oxalic acid for calcium in urine; and the vitamin B6 promotes the combination ofthe citric acid with urine calcium so as to reduce the chance of forming calcium oxalate stones. The health agent is reasonable in compatibility, and jointly uses medicaments from different angles toeliminate the inducing factors of magnesium ammonium phosphate and calcium oxalate urinary calculi which are the most common among dogs.
Owner:TIANJIN SHENGJI GRP CO LTD
Oxalate-degrading strain NJODE1 and application thereof
ActiveCN102250799AGood acid and bile salt resistanceNo antibiotic resistanceMilk preparationBacteriaAntibiotic resistanceGastrointestinal absorption
The invention discloses an oxalate-degrading strain NJODE1 and application thereof. The oxalate-degrading strain NJODE1 has a classification name of Enterococcus faecium with the preservation number of CGMCC NO. 4581. The oxalate-degrading strain NJODE1 has good tolerance to acids and bile salts, has no antibiotic resistance to most non-antibiotics, is safe for mice and can be colonized in dogs. The NJODE1 can reduce gastrointestinal absorption of oxalate in foods, thereby reducing the content of oxalate in urine, and thus reducing the incidence of canine calcium oxalate calculus. Whether thefinished product of the strain is food or pharmaceutical products or yogurt and fermented milk, the strain has good resistance to acids and bile salts, contains safe enterococci, and has significant effects on lowering the urinary oxalate content and preventing and treating calcium oxalate calculus of pets, thus having broad application prospects.
Owner:NANJING AGRICULTURAL UNIVERSITY
Prescription diet for calcium oxalate calculus of dogs
InactiveCN109303190ANutritional diversityReduce oxalic acid contentAnimal feeding stuffAccessory food factorsBiotechnologyCalcium oxalate calculus
The invention relates to the technical field of pet feed, in particular to a prescription diet for calcium oxalate calculus of dogs. The dog food mainly comprises the following raw materials in partsby weight: 70-90 parts of corn, 15-25 parts of beef, 10-15 parts of fish, 10-20 parts of duck, 5-10 parts of dried cranberries, 2-3 parts of poria cocos, 3-5 parts of semen plantaginis, 5-10 parts ofchicken oil, 5-10 parts of peanut oil, 1-2 parts of premixes and 1-5 parts of salt. The dog food provided by the invention is characterized in that the beef, the fish and the duck, which are rich in trace element, are added into the raw materials, and diuretic traditional Chinese medicinal materials such as the poria cocos and the semen plantaginis are also added; through increase of the amount ofurine of the pet dogs, the concentration of oxalic acid in the urine is reduced, and small calcium oxalate crystals are carried out of the bodies to prevent retention of the calcium oxalate calculusin the bodies.
Owner:华兴宠物食品有限公司
Composition for preventing urinary stone
InactiveCN105030952AReduce formationReduce excretionOrganic active ingredientsUrinary disorderCalcium oxalate calculusAdditive ingredient
The invention provides a composition for preventing urinary stone. The composition comprises 1wt% or more of a prune juice. The composition can be used as a health food or a health drug and can also comprise pharmaceutically or bromatologically acceptable carriers. The composition comprises prune juice ingredients as effective ingredients such as neochlorogenic acid, chlorogenic acid, caffeoylquinic acid, procyanidin oligomer, a flavonoid compound and rutin. An experiment proves that the prune juice has effects of preventing calcium oxalate calculus of kidney and provides a safe and effective prevention product with a simple source and a low price for kidney calcium oxalate calculus invalidous, subhealth people and health people.
Owner:SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
Application of commercially available yoghourt in preventing urinary calculus
The invention relates to application of yoghourt in the field of preventing urinary calculus. Lactobacillus in the yoghourt has the effect of resolving oxalic acid, can degrade food-borne oxalic acid in intestinal tract, and reduce absorptive amount of the intestinal tract to the oxalic acid, so the yoghourt has the efficacy of preventing urinary calculus of the oxalic acid; and the yoghourt has important application in the fields of medicines, foods and health products. Through animal experiments, the invention provides that urinary oxalate excretion can be effectively reduced by drinking commercial yoghourt, thereby exploring a practical approach in preventing relapse of oxalate calcium calculus. The yoghourt has a plurality of obvious characteristics in health-care function and medicine-food homologization, and has the advantages of low cost, convenient taking and high compliance degree compared with a patient taking drugs, and does not have any side effect, so the yoghourt has better potential of prevention use.
Owner:上海交通大学医学院附属第三人民医院
Oral composition for dissolving calcium oxalate calculus
InactiveCN108853170AEasy to control the dissolution timeConvenient time controlOrganic active ingredientsPharmaceutical non-active ingredientsCalcium oxalate calculusSide effect
The invention provides an oral composition for dissolving calcium oxalate calculus. The composition contains 0.1-10% of garcinia cambogia extract microcapsules or 0.1-10% of hydroxycitric acid or hydroxycitric acid derivative microcapsules. The composition contains garcinia cambogia extract microcapsules, hydroxycitric acid or hydroxycitric acid derivative microcapsules, so that calculus formed bycalcium oxalate crystals can be effectively dissolved; the materials of the garcinia cambogia extract microcapsules, hydroxycitric acid or hydroxycitric acid derivative microcapsules adopt organic polymer materials, which have certain dissolvability and are capable of conveniently controlling disintegration and dissolution time of the composition and protecting effective components in the composition to reach efficient absorption parts. The composition adopts natural extracts, is free of toxic and side effects on human body and excellent in calculus dissolving effect, can be orally taken by broad crowds, is free of strict restrictions on the crowds, and has broad application prospects.
Owner:NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
Preparation method of dry powder and fungus powder containing jinfu mushroom oxalate decarboxylase
ActiveCN102697040BIncrease vitalityEfficient degradationPowder deliveryMicroorganism based processesIntestinal structureTricholoma giganteum
The invention discloses a preparation method of dry powder and fungus powder containing Tricholoma lobayense Heim oxalate decarboxylase and relates to the field of degradation of oxalate in stomachs and intestines of human bodies or animal bodies. The preparation method comprises the following steps of: using Tricholoma lobayense Heim or sibling fungi thereof as raw materials, culturing thalli by adopting a liquid fermentation method, regulating pH (potential of hydrogen) of fermentation solution to 2.0-5.0, inducing to produce oxalate decarboxylase, collection the fermentation solution and the thalli, crushing the thalli, conducting solid-liquid separation to respectively obtain liquid and solid containing the Tricholoma lobayense Heim oxalate decarboxylase, and respectively drying the obtained liquid and solid after separation to obtain the dry powder and the fungus powder containing the Tricholoma lobayense Heim oxalate decarboxylase. The dry powder and the fungus powder containing the Tricholoma lobayense Heim oxalate decarboxylase can be used for oxalic acid removal of food, beverage, feed and the like, can also be used as raw materials to prepare healthcare products or medicines, is suitable for oral taking, can effectively degrade oxalic acid and oxalate and can prevent or cure urine oxalic acid excess symptoms and calcium oxalate calculi.
Owner:WUHAN KANGFUDE BIOTECH CO LTD
Intestinal flora marker for diagnosing calcium oxalate calculus and application of intestinal flora marker
The invention discloses an intestinal flora marker for diagnosing calcium oxalate calculus and application of the intestinal flora marker. The invention relates to an application of a reagent for detecting the abundance of Burkholderia pseudomallei and / or Bacteroides sp.CAG:443 in the preparation of a reagent for diagnosing calcium oxalate calculus. According to the present invention, it is found for the first time that Burkholderia pseudomacrolei and Bacteroides sp.CAG:443 are related to calcium oxalate calculus, the abundance of Burkholderia pseudomacrolei and Bacteroides sp.CAG:443 has significant difference in calcium oxalate calculus patients and healthy people, ROC curve analysis results show that the Burkholderia pseudomacrolei and Bacteroides sp.CAG:443 as detection variables have high specificity and high sensitivity, such that Burkholderia pseudomacrolei and / or Bacteroides sp.CAG:443 can be used as detection markers for diagnosis of calcium oxalate calculus patients. Burkholderia pseudomacrolei and / or Bacteroides sp.CAG:443 are / is used as a detection marker, so that the marker is completely noninvasive and is high in accuracy.
Owner:GUANGXI MEDICAL UNIVERSITY
Methods for identifying a companion animal susceptible to treatment that reduces the risk of stone formation and compositions for reducing such risk
ActiveUS11155856B2Reduce riskMicrobiological testing/measurementAnimal feeding stuffBiotechnologyBetaine
Methods of analyzing a biological sample obtained from the feline subject for the presence of two copies of major allele G of SNP A1_212891692 and / or to the concentration of betaine and / or 2-oxoarginine in the sample are disclosed. The methods are used in methods to identify a feline subject that would benefit from a treatment that reduces risk of calcium oxalate stone formation and in methods of treating a feline subject to reduce risk of calcium oxalate stone formation The treatment on comprises administering to the feline subject a composition that comprises an effective amount of one or more of ingredients selected from the group consisting of betaine, green tea, fenugreek and tulsi. Feline food composition that comprise effective amounts of betaine, green tea, fenugreek and tulsi are disclosed.
Owner:HILLS PET NUTRITION INC
Application of edible lactobacillus in preventing urinary calculus
InactiveCN101485688ABacteria material medical ingredientsUrinary disorderCalcium oxalate calculusSide effect
The invention relates to application of edible lactobacillus in the prevention of urinary calculi. Lactobacillus has the effect of decomposing oxalic acid, can degrade food-borne oxalic acid in an intestinal tract, and reduce the absorption capacity of the intestinal tract to the oxalic acid, so the lactobacillus has the efficacy of preventing calcium oxalate urinary calculi and also has important application in the fields of medicine, food and health care products. The invention proposes that the edible lactobacillus can effectively reduce the excretion of urinary oxalic acid through an animal experiment, and explore a practical way for preventing the recurrence of calcium oxalate calculi. Yoghurt which is taken as a main source of the edible lactobacillus synchronously has various remarkable health care functions and the characteristic of homology of medicine and food, and has the advantages of low cost, convenient eating, and high compliance compared with drug patients. At the same time, the yoghurt also has no any side effect and has better prevention use potential.
Owner:NO 3 PEOPLE HOSPITAL AFFILIATED TO SHANGHAI JIAOTOG UNIV SCHOOL OF MEDICINE
Methods for Identifying a Companion Animal Susceptible to Treatment That Reduces the Risk of Stone Formation and Compositions for Reducing Such Risk
ActiveUS20200239941A1Reduce riskMicrobiological testing/measurementAnimal feeding stuffBiotechnologyBetaine
Methods of analyzing a biological sample obtained from the feline subject for the presence of two copies of major allele G of SNP A1_212891692 and / or to the concentration of betaine and / or 2-oxoarginine in the sample are disclosed. The methods are used in methods to identify a feline subject that would benefit from a treatment that reduces risk of calcium oxalate stone formation and in methods of treating a feline subject to reduce risk of calcium oxalate stone formation The treatment on comprises administering to the feline subject a composition that comprises an effective amount of one or more of ingredients selected from the group consisting of betaine, green tea, fenugreek and tulsi. Feline food composition that comprise effective amounts of betaine, green tea, fenugreek and tulsi are disclosed.
Owner:HILLS PET NUTRITION INC
Method for quickly detecting and analyzing components of canine cat urinary calculi
InactiveCN101655485AThe method is scientific and reasonableEasy to operateMaterial analysis by observing effect on chemical indicatorChemical methods analysisMagnesium ammonium phosphateBiology
Owner:TIANJIN SHENGJI GRP CO LTD
Methods for Identifying a Companion Animal at Risk of Calcium Oxalate Stone Formation and Treatments and Compositions for Reducing the Risk
PendingUS20210189492A1Reduce riskIncrease likelihoodMicrobiological testing/measurementAccessory food factorsCalcium oxalate calculusPhysiology
Methods of analyzing a biological sample obtained from the feline subject for the presence of one or two copies of minor allele A of SNP A1_212891692 and / or to the concentration of beta-amino isobutyrate and / or 2-oxoarginine concentrations in the sample are disclosed. The methods are used in methods to identify a feline subject that has an increased likelihood or risk of calcium oxalate stone formation and in methods of treating a feline subject to reduce risk of calcium oxalate stone formation. The treatment on comprises administering to the feline subject a low arginine diet. Low arginine feline food compositions are disclosed.
Owner:HILLS PET NUTRITION INC
Methods for identifying companion animals at risk of calcium oxalate calculus formation and treatments and compositions for reducing said risk
PendingCN114787387AMicrobiological testing/measurementAnimal feeding stuffCalcium oxalate calculusObstetrics
Disclosed are methods of analyzing the presence of one or two copies of the minor allele A of SNP A 1212891692 in a biological sample obtained from a feline subject and / or the concentration of beta-aminoisobutyrate and / or 2-oxoarginine in said sample. The methods can be used in methods for identifying feline subjects with an increased likelihood or risk of calcium oxalate calculus formation and methods for treating feline subjects to reduce the risk of calcium oxalate calculus formation. The treatment comprises administering a low arginine diet to the feline subject. A low arginine feline food composition is disclosed.
Owner:HILLS PET NUTRITION INC
Artificial calculus preparation method
Owner:THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
Additive for improving urinary tract calculi of pets as well as preparation method and application of additive
PendingCN113940388AReduces the probability of crystal formationVolatile lossAnimal feeding stuffAccessory food factorsCalcium oxalate calculusDiuresis
The invention relates to an additive for improving urinary tract calculi of pets as well as a preparation method and application of the additive. Urinary tract health functional substances such as fructus arctii, medium-chain fatty acid, citric acid and lactic acid are prepared into the additive, the additive is anti-inflammatory and diuretic, the PH value of urine is reduced to promote dissolution of dog struvite, and formation of pet struvite and calcium oxalate calculi is reduced. The additive can be added to the pet daily ration in the form of a functional bag, and only 1-2% of the additive needs to be added to the pet daily ration, so that the effect of remarkably improving and preventing the conditions of struvite and calcium oxalate calculi of pets can be achieved.
Owner:SHANGHAI FUBEI PET PROD CO LTD
Application of mechanism of BMP2 silencing in elimination of renal calcium oxalate calculus injuries
PendingCN113384684AReduce oxidative stressReduce crystallizationPeptide/protein ingredientsUrinary disorderPhosphorylationCaox crystal
The invention relates to the field of biological medicines, and discloses application of a mechanism of BMP2 silencing in elimination of renal calcium oxalate calculus injuries, and the mechanism is as follows: CaOx crystal deposition and renal cell injuries are reduced by inhibiting oxidative stress reaction through BMP2 silencing. The invention proves that the BMP2 silencing can alleviate sodium oxalate-induced cell oxidative stress and crystallization, and can inhibit phosphorylation of Smad1 and expression of NOX2 and NOX4, proves that the BMP2 silencing can reduce CaOx crystal deposition and renal cell injuries by inhibiting the oxidative stress reaction, and shows that the BMP2 silencing can eliminate the renal tubular epithelial cell oxidative stress injuries. A new direction is indicated for the pathogenesis research of the calcium oxalate calculus .
Owner:WEST CHINA HOSPITAL SICHUAN UNIV
Oxalate-degrading strain NJODE1 and application thereof
ActiveCN102250799BImprove toleranceNo antibiotic resistanceMilk preparationBacteriaAntibiotic resistanceGastrointestinal absorption
The invention discloses an oxalate-degrading strain NJODE1 and application thereof. The oxalate-degrading strain NJODE1 has a classification name of Enterococcus faecium with the preservation number of CGMCC NO. 4581. The oxalate-degrading strain NJODE1 has good tolerance to acids and bile salts, has no antibiotic resistance to most non-antibiotics, is safe for mice and can be colonized in dogs. The NJODE1 can reduce gastrointestinal absorption of oxalate in foods, thereby reducing the content of oxalate in urine, and thus reducing the incidence of canine calcium oxalate calculus. Whether thefinished product of the strain is food or pharmaceutical products or yogurt and fermented milk, the strain has good resistance to acids and bile salts, contains safe enterococci, and has significant effects on lowering the urinary oxalate content and preventing and treating calcium oxalate calculus of pets, thus having broad application prospects.
Owner:NANJING AGRICULTURAL UNIVERSITY
A kind of Huashi Paishi granule for preventing and treating calcium oxalate stones and its preparation method
ActiveCN104258218BImprove protectionProtection reachedPteridophyta/filicophyta medical ingredientsUrinary disorderCalcium oxalate calculusPyrrosia lingua
Owner:湖北省中医院
Organic acids as agents to dissolve calcium minerals in pathological calcification and uses thereof
ActiveUS10285961B2Growth inhibitionOrganic active ingredientsOrganic chemistryCalcium oxalate calculusOrganic acid
In an embodiment of the present disclosure, there is provided a composition for dissolving calcium oxalate crystals thereby inhibiting / preventing further growth of crystals. In some embodiments, such a composition comprises at least one stereoisomer of hydroxycitrate, a derivative of the organic acid citrate. Such a method comprises administering to the subject an effective amount of the aforementioned composition. In another embodiment, the present disclosure pertains to a method of treating kidney stone disorder. Such a method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition. In yet another embodiment, the present disclosure relates to a method of treating calcium oxalate stone disease. In an embodiment, the method comprises administering to a subject in need thereof a therapeutically effective amount of the aforementioned composition.
Owner:UNIV HOUSTON SYST
Oxalic acid degrading bacterium NJODL1 and application thereof
ActiveCN102250800BImprove toleranceNo antibiotic resistanceMilk preparationBacteriaOXALIC ACID DIHYDRATEStaphylococcus lactis
Owner:NANJING AGRICULTURAL UNIVERSITY
Artificial calculus preparation method
The invention relates to an artificial calculus preparation method, which is required by the efficacy detection of extra-corporeal lithotriptor with ultrasonic shock-waves. The invention comprises the steps: fixing two templates on a bottom plate to form a mould; selecting 80-90 wt% of calcium sulfate hexahydrate and 15-5 wt% of polyacrylamide of which the consistence is 0.1%; quickly and evenly stirring; putting into the mould; striking off size extruding out of aperture by a plastic plate, and naturally drying in the air; solidifying, removing nuts, separating a model calculus mould, and taking out the model calculus. The invention overcomes the defects that the existing artificial calculus has atypical physical property, or physical property is similar to natural calculus, the preparation method is too complex, cost is high and the like. The physical property of the artificial calculus prepared by the invention is similar to whewellite calculus, can obtain vivid detection data and is favourable for accurately evaluating efficacy situation thereof, and the method is simple and convenient.
Owner:THE AFFILIATED DRUM TOWER HOSPITAL MEDICAL SCHOOL OF NANJING UNIV
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