The invention discloses a distributed model-free self-adaptive control technology for indoor heating, ventilation and air conditioning of a building, and belongs to the field of intelligent control. In order to solve the problem of building indoor multi-zone temperature control with complex topological information and external disturbance, the control scheme is as follows: establishing a dynamic model of a multi-zone heating ventilation air conditioner, writing the dynamic model into a matrix form, and discretizing the dynamic model; a single room physical model is expressed as a general non-affine nonlinear system, and a linear data model containing a pseudo gradient is converted through a differential median theorem; based on a linear data model, a distributed model-free adaptive control law is designed in combination with topology information; and designing a parameter estimation index function by combining a linear data model, and estimating an unknown pseudo gradient in the control method. According to the distributed model-free self-adaptive control technology for the indoor heating, ventilation and air conditioning of the building, a data driving method is used, the method does not depend on model information, only online and offline data and related topological information are used, the temperature adjusting performance of the heating, ventilation and air conditioning is improved, and the indoor temperature adjusting requirement of the building is met.