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Compound non-carrier antibacterial eye drops containing practofren and its production

An ophthalmic preparation and compound recipe technology are applied in the field of compound antibacterial ophthalmic preparations and their preparation, which can solve the problems of reduced curative effect, turbidity, turbidity of eye drops, etc. Effect

Active Publication Date: 2011-04-06
SHANGHAI SINE PHARMA LAB
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the properties of "Fumeixin" eye drops are somewhat turbid, which affects patients' compliance
This is because when aminoglycoside antibacterial drugs are directly mixed with non-steroidal drugs to make a solution, turbidity will occur, and eye drops with turbidity will also have disadvantages such as unstable storage and reduced curative effect.

Method used

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  • Compound non-carrier antibacterial eye drops containing practofren and its production

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1: Pranoprofen Gentamicin Eye Drops

[0056] Gentamicin 15g

[0057] Pranoprofen 5g

[0058] Sodium dihydrogen phosphate (anhydrous) 8.5g

[0059] Disodium hydrogen phosphate (anhydrous) 41.7g

[0060] Polyvinylpyrrolidone K30 60g

[0061] Sodium chloride 20g

[0062] Ethylparaben 1.5g

[0063] Sterile distilled water 5,000ml

[0064] Preparation Process:

[0065] 1) Weigh the above-mentioned amount of sodium dihydrogen phosphate (anhydrous) and disodium hydrogen phosphate (anhydrous) into a stainless steel bucket, and add 1000 ml of sterilized distilled water therein, while stirring to fully dissolve them. The resulting homogeneous solution was placed at room temperature;

[0066] 2) Weigh the above-mentioned amount of ethyl paraben and place it in another stainless steel pot, and add 1000ml sterilized distilled water thereinto, heat and stir simultaneously to make it dissolve to obtain a uniform solution;

[0067] 3) Add the solution obtained in st...

Embodiment 2

[0070] Embodiment 2: Diclofenac Sodium Gentamicin Eye Drops

[0071] Gentamicin 15g

[0072] Diclofenac Sodium 5g

[0073] Sodium dihydrogen phosphate (anhydrous) 8.5g

[0074] Disodium hydrogen phosphate (anhydrous) 41.7g

[0075] Polyvinylpyrrolidone K30 60g

[0076] Sodium chloride 20g

[0077] Ethylparaben 1.5g

[0078] Sterile distilled water 5,000ml

[0079] The preparation process is as described in Example 1.

Embodiment 3

[0080] Embodiment 3: Pranoprofen Tobramycin Eye Drops

[0081] Tobramycin 5.0g

[0082] Pranoprofen 5.0g

[0083] Sodium dihydrogen phosphate (anhydrous) 8.5g

[0084] Disodium hydrogen phosphate (anhydrous) 41.7g

[0085] Polyvinylpyrrolidone K30 60.0g

[0086] Sodium chloride 20.0g

[0087] Ethylparaben 1.5g

[0088] Sterile distilled water 5,000ml

[0089] The preparation process is as described in Example 1.

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Abstract

An antibacterial eye medicine containing pranoprofen contains non-steroid antiphlogistic medicine, aminoglycoside-type antibacterial medicine, polyvinyl pyrrolidone, and pharmacologically acceptable carrier. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a compound antibacterial ophthalmic preparation of non-steroidal drugs and aminoglycoside antibacterial drugs and a preparation method thereof. Background technique [0002] At present, antihistamines, anticongestants, mast cell stabilizers, corticosteroids and non-steroidal anti-inflammatory agents are mainly used clinically to treat various ocular inflammation and allergic symptoms. Long-term use of antihistamines, anticongestants, mast cell stabilizers, and corticosteroids (especially corticosteroids) may cause serious adverse reactions such as hypofunction of the adrenal cortex, induced ulcer disease, and mental disorders. [0003] Non-steroidal anti-inflammatory drugs have anti-inflammatory, anti-allergic and analgesic effects without the adverse reactions of corticosteroids, so they are increasingly used in ophthalmology. Currently commonly used non-steroidal anti-inflammatory eye drops include indomethacin eye drops, di...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/196A61K45/06A61P37/08A61K31/436A61K31/79A61P29/00A61K31/7036A61K9/00
Inventor 朱正鸣乌旭琼夏凌云陈佩丽
Owner SHANGHAI SINE PHARMA LAB
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