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Immunoglobulin for anti gosling plague

A technology of immunoglobulin and gosling plague, which is applied in the direction of antibodies, antiviral agents, virus antigen components, etc., can solve the problems of high titer of neutralizing antibodies, large amount of preparation, and small amount of passive immunization, achieving small injection doses , convenient transportation and easy operation

Inactive Publication Date: 2007-05-09
张中洋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Even without the above-mentioned risks, there are many problems in the preparation of high-quality products (such as refined immunoglobulin), high titer of neutralizing antibodies, small amount of passive immunization, and large amount of preparation in the whole process.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] The immunogen of the present invention adopts gosling plague live vaccine (commercially available, and the duck embryo detects that every feather part≥10 3 ELD 50 , 100 feathers / bottle); goose plague GB strain (Guangdong Foshan Academy of Veterinary Science donated goose embryo test, each 0.3ml contains more than 10 3 ELD); the mixing volume ratio of gosling plague live vaccine and gosling plague GB strain is 1: 1.5;

[0032] Adjuvant: complete Freund's adjuvant;

[0033] Immune enhancer: glycoside injection developed by Jilin Jingxiang Animal Pharmaceutical Co., Ltd., 5ml / bottle;

[0034] The volume ratio of immunogen and complete Freund's adjuvant was 1:1.

[0035] Immunization program

[0036] Blood test, exsanguination and serum separation

[0037] Basic immunization for horses (muses, donkeys) once. Multiple subcutaneous injections on both sides of the back. Preparation of immunogen 1: Dilute 100 feathers / bottle of vaccine with 3ml of normal saline, mix evenly...

Embodiment 2

[0048] The immunogen of the present invention adopts gosling plague live vaccine (commercially available, and the duck embryo detects that every feather part≥10 3 ELD 50 , 100 feathers / bottle); goose plague GB strain (Guangdong Foshan Academy of Veterinary Science donated goose embryo test, each 0.3ml contains more than 10 3 ELD); the mixing volume ratio of gosling plague live vaccine and gosling plague GB strain is 1.5: 1.2;

[0049] Adjuvant: complete Freund's adjuvant;

[0050] Immune enhancer: glycoside injection developed by Jilin Jingxiang Animal Pharmaceutical Co., Ltd., 5ml / bottle;

[0051] The volume ratio of immunogen and complete Freund's adjuvant was 1:1.

[0052] The immunization procedure is the same as in Example 1.

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Abstract

An immunoglobulin for preventing the pest of gooselet is prepared from the allantoic fluid of the embryo of goose or duck suffering from the pest through cell culture, concentrating and proportionally mixing it with complete Frennd's adjuvant. It features that the glycoside-peptide injection is used as its immunopotentiator.

Description

technical field [0001] The invention belongs to the field of biotechnology, and specifically relates to an immunoglobulin for treating and preventing goose plague prepared by using two kinds of immunogens. The international patent classification number is: A61K39 / 395. Background technique [0002] Synonyms of gosling plague: gosling parvovirus, gosling hepatitis, gosling exudative enteritis. Gosling plague is caused by goose parvovirus (Goose Parvovirus), which is mainly caused by gosling acute enteritis and solid organs such as liver, kidney and heart. After the newly hatched goslings were infected with the virus, after an incubation period of 4 to 5 days, most of them died of acute sepsis. The goslings with the smallest disease usually start at the age of 3 to 5 days, and spread to the whole group within a few days, and the mortality rate can reach 70% to 95%. It is a major hazard to the goose industry. [0003] my country's research on this infectious disease is at the...

Claims

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Application Information

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IPC IPC(8): A61K39/395A61K39/12A61K39/39A61P31/12
CPCY02A50/30
Inventor 张中洋
Owner 张中洋
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