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Triple high immunity immunoglobulin for anti transmissible gastroenteritis of pig, epidemic diarrhea of pig, and rotavirus of pig

A technology for porcine epidemic diarrhea and porcine rotavirus, which is applied in the directions of antiviral agents, antibodies, and antibody medical components, can solve problems such as unsatisfactory treatment effects, and achieve the effects of short half-life, fast metabolism and good safety

Inactive Publication Date: 2007-05-09
张中洋
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Since there is no specific drug for viral diseases, clinical treatment mainly adopts symptomatic treatment and antibiotics to prevent complications, and the treatment effect is not ideal

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The immunogen of the present invention is prepared by adding complete Freund's adjuvant after concentrated cell culture, wherein the porcine transmissible gastroenteritis virus is cultured with primary cells of suckling pig kidney or subcultured pig kidney cells (PK-15); Porcine epidemic diarrhea virus was cultured in Vero cells; porcine rotavirus was cultured in MA 104 cell line or CV 1 Cell culture; the concentration of these three viruses should not be less than 10 6 , the three immunogens were mixed in a ratio of 1:2:1 and Freund's complete adjuvant was added in a volume ratio of 1:1 to immunize animals as immunogens; at the same time, the glycosides developed by Jilin Whale Elephant Animal Pharmaceutical Co., Ltd. were used Injection, 5ml / bottle, as an immune enhancer.

[0037] Immunization program

[0038] The immunization route adopts intradermal, subcutaneous or acupoint or intramuscular multi-point injection. The basic immunization dose is 3ml per pig and 5...

Embodiment 2

[0053] The immunogen of the present invention is prepared by adding complete Freund's adjuvant after concentrated cell culture, wherein the porcine transmissible gastroenteritis virus is cultured with primary cells of suckling pig kidney or subcultured pig kidney cells (PK-15); Porcine epidemic diarrhea virus was cultured in Vero cells; porcine rotavirus was cultured in MA 104 cell line or CV 1 Cell culture; the concentration of these three viruses should not be less than 10 6 , the three immunogens were mixed in a ratio of 1.5:2:3 and Freund's adjuvant was added as the immunogen to immunize animals; at the same time, the glycoside injection developed by Jilin Whale Elephant Animal Pharmaceutical Co., Ltd. was used as an immune enhancer.

[0054] The preparation method is the same as in Example 1.

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Abstract

An immunoglobulin for preventing the infectious gastroenteritis, epidemic diarrhea and rotavirus of hog is prepared from their immunogens through cell culture, concentrating and proportionally mixing it with complete Frennd's adjuvant. It features that the glycoside-peptide injection is used as its immunopotentiator.

Description

technical field [0001] The invention belongs to the field of biotechnology, and specifically relates to an immunoglobulin against porcine infectious gastroenteritis, porcine epidemic diarrhea and porcine rotavirus. The international patent classification number is A61K39 / 395. Background technique [0002] Porcine transmissible gastroenteritis, porcine epidemic diarrhea and porcine rotavirus infection are three important viral infectious diseases that have been confirmed to cause diarrhea in pigs. These three diseases mainly have a greater impact on piglets, and are the main viral diarrhea diseases that cause piglet death. These three diseases are often co-infected, and are very similar in epidemiology, clinical symptoms, and pathological and anatomical changes. It is difficult to distinguish which virus is infected, and the onset is rapid. It affects the whole group, mainly causing a large number of deaths of lactating piglets and causing huge losses to pig production. [...

Claims

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Application Information

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IPC IPC(8): A61K39/295A61K39/39A61K39/395A61P31/12
Inventor 张中洋
Owner 张中洋
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