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Pharmaceutical use of paeonol for anti esophageal cancer

A technology of paeonol and esophageal cancer, applied to the application field of paeonol in the treatment of esophageal cancer, can solve problems such as no reports of paeonol, and achieve the effects of no adverse reactions and less toxic and side effects

Inactive Publication Date: 2007-03-28
孙国平 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far there is no report on the effect of paeonol on esophageal cancer

Method used

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  • Pharmaceutical use of paeonol for anti esophageal cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Component Quantity (mg / bag)

[0055] Paeonol-β-cyclodextrin inclusion complex 1850 (equivalent to paeonol 150mg)

[0056] Mannitol 2800

[0057] Sodium Carboxymethyl Cellulose 250

[0058] Microcrystalline Cellulose 100

[0059] Preparation:

[0060] (1) Weigh 1 g of paeonol, add an appropriate amount of absolute ethanol, and heat in a water bath to dissolve; another 10 times the amount of β-cyclodextrin is weighed and placed in a three-necked flask, and dissolved in water at a certain temperature to make a saturated solution; The paeonol absolute ethanol solution was slowly added dropwise to the β-cyclodextrin saturated solution at a rate of 2 drops / min, and the three-necked flask was sealed after the absolute ethanol evaporated. Continue to heat in a water bath and stir for a period of time, take it out, put it in the refrigerator for 24 hours to crystallize, filter to obtain the clathrate, wash with a small amount of distilled water, and dry it in a vacuum drying...

Embodiment 2

[0063] Component Quantity (mg / tablet)

[0064] Paeonol 50

[0065] Mannitol 175

[0066] Croscarmellose Sodium 23

[0067] Magnesium Stearate 2

[0068] PVP K 30 Proper amount of ethanol solution

[0069] Preparation:

[0070] In the GMP purification workshop, after paeonol and the above-mentioned auxiliary materials are mixed in proportion, according to the Chinese Pharmacopoeia 2005 edition one preparation tablet standard, granulate, press with automatic tablet machine, make tablet, each tablet contains The paeonol-containing amount is 50 mg, and the patient takes 3 tablets each time, 1-5 times a day.

Embodiment 3

[0072] Component Quantity (mg / pill)

[0073] Paeonol 50

[0074] vegetable oil 200

[0075] Preparation:

[0076] In the GMP purification workshop, mix paeonol with vegetable oil, and grind it evenly with a colloidal mill; add gelatin solution (100 parts of gelatin, 55 parts of glycerin, and 120 parts of water) for later use; use an automatic pellet machine to make soft capsules Each pill contains 50 mg of paeonol, and the patient takes 3 pills each time, 1-5 times a day.

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Abstract

The present invention discloses an application of paeonol in preparation of medicine for curing carcinoma of esophagus. Said medicine can be made into various dosage forms.

Description

Technical field: [0001] The invention relates to the technical field of medicine, and more specifically relates to the application of paeonol in the treatment of esophageal cancer. Background technique: [0002] Esophageal cancer is a malignant tumor that occurs in the esophageal epithelium, accounting for 2% of all malignant tumors. The latest statistics show that there are nearly 400,000 new cases and 340,000 deaths worldwide every year. my country is the country with the highest incidence of esophageal cancer, accounting for more than 50% of the world's esophageal cancer, and its mortality rate ranks fourth among all tumors. Our province is a province with a high incidence of esophageal cancer. According to the 1990-1992 sample survey report on the cause of cancer death in Anhui Province, esophageal cancer ranks second in the cause of cancer death in our province and the first cause of cancer death in men. At least 80% of patients with esophageal cancer have local invas...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/12A61P35/00
Inventor 孙国平桂双英王华
Owner 孙国平
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