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Medicine for treating myocardial ischemia disease and its preparing process

A technology of myocardial ischemia and pharmaceutical preparations, which is applied in the field of drugs for treating heart diseases and drugs for treating myocardial ischemic diseases. Effects of microcirculation and reduction of infarct size

Inactive Publication Date: 2007-02-07
张介眉
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there is no lack of high-efficiency and cheap medicines in western medicine treatment at present, they have serious side effects and are contraindicated for glaucoma, so they cannot be taken for a long time
Traditional Chinese medicines such as Suxiao Jiuxin Pills and Danshen Dropping Pills have reliable curative effects on this disease, have little toxic and side effects, and can be taken for a long time, but their prices are relatively high, and their clinical use is limited.

Method used

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  • Medicine for treating myocardial ischemia disease and its preparing process
  • Medicine for treating myocardial ischemia disease and its preparing process
  • Medicine for treating myocardial ischemia disease and its preparing process

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0144] Embodiment 1 Preparation of scallion white volatile oil

[0145] Take shallots produced in Huangpi, Hubei, wash, pick and peel off the white scallions, and cut the scallions into fine pieces; freeze the shallots at -10 to -80°C with a freeze dryer to make them solid; dry the solid scallions obtained by freeze-drying with CO 2 The essential oil was extracted by supercritical extraction. The extraction pressure is 25MPa, the temperature is 38°C, CO 2 The flow rate is 9kg·h-1, and the extraction time is 2h. 100 grams of spring onion can get 40 grams of scallion white, and every 100 grams of scallion white can get 5ml of volatile oil.

Embodiment 2

[0146] Embodiment 2 The preparation of medicine dropping pill preparation of the present invention

[0147] Select polyethylene glycol (PEG) 4000 with low melting point, good dispersibility and large cohesive force and PEG-6000 for adjusting the hardness, heat resistance and fluidity of dripping pills as carriers, and use Tween-80 as the enhancer. Solvent, adjust the melting point with stearic acid.

[0148] Prescription: scallion white volatile oil 5ml; PEG-4000 50g; PEG-6000 6g; Tween-80 0.6g; stearic acid 0.9g.

[0149] Weigh 50g PE6-4000 and put it in a water pot to melt, control the temperature at about 50°C, and keep stirring until the liquid is clear and no bubbles escape, add 0.6g Tween-80, then add 55ml scallion white volatile oil, stir evenly, keep warm spare;

[0150] Then add 6g PEG-6000 and 0.9g stearic acid to melt;

[0151] Pass the above-mentioned medicinal liquid through a 100-mesh sieve while it is hot, filter it to obtain the medicinal liquid, keep it war...

Embodiment 3

[0152] Embodiment 3 The preparation of medicament spray of the present invention 1

[0153] Reagent: polyethylene glycol 400, produced by Beijing Yili Fine Chemicals Co., Ltd.;

[0154] Triethanolamine, produced by Shenyang Reagent Factory;

[0155] Pemulen, produced by BFGoodrich;

[0156] Disodium EDTA, produced by Huabo Company of Shenyang Pharmaceutical Co., Ltd.;

[0157] Methanol, produced by Yucheng Chemical Plant of Shandong Yuwang Industrial Co., Ltd.;

[0158] The rest of the reagents were commercially available analytically pure.

[0159] Selection of excipients: Pemulen polymer is a polymer formed by cross-linking and polymerizing acrylic monomers, which can swell in water, and can form a transparent semi-solid spray when neutralized with alkali. Pemulen has been widely used in external pharmaceutical preparations and is an excellent bioadhesive material;

[0160] Xanthan gum (XG) is a high-molecular natural carbohydrate polysacch...

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Abstract

The invention relates to a drug used to treat myocardial ischemia, which uses Chinese green onion as raw material, uses CO2 ultra-critical extracted Chinese green onion benzene; and the extraction comprises: a, breaking the Chinese green onion, and cooling it into -10 to -80Deg. C by refrigerating drier, to make solid Chinese green onion powder; b, extracting the powder via CO2 ultra-critical extraction method, at 25MPa pressure, 38Deg. C, and the flux of CO2 is 9kg.h-1, and extracting for 2h, to obtain the Chinese green onion extractive; using Chinese green onion benzene as effective component to obtain drop and spray agent. The invention can improve micro cycle, reduce the blood vessel resistance, and reduce the heart load.

Description

technical field [0001] The invention relates to medical medicine, especially medicine for treating heart disease, especially medicine for treating myocardial ischemia disease. Background technique [0002] Coronary atherosclerotic heart disease refers to heart disease caused by coronary artery sclerosis that blocks the lumen, resulting in myocardial ischemia and hypoxia. It is collectively referred to as coronary heart disease together with functional changes of coronary arteries such as spasm. The treatment of coronary heart disease has always been a worldwide problem. Although there is no shortage of high-efficiency and cheap medicines for Western medicine treatment at present, they have large toxic and side effects and are contraindicated for glaucoma, so they cannot be taken for a long time. Traditional Chinese medicines such as Suxiao Jiuxin Pills and Danshen Dropping Pills have reliable curative effects on this disease, have little toxic and side effects, and can be ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61P9/10A61K125/00
Inventor 张介眉
Owner 张介眉
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