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Medicinal preparation containing ginseng and aconite root in raw material and its preparing method and quality control method

A technology of pharmaceutical preparations, ginseng, applied in the field of pharmaceutical preparations

Active Publication Date: 2007-01-24
深圳市资福药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But it does not retain the polysaccharides in ginseng as a main active ingredient in the finished preparation, such as Chinese application (patent) No. CN96117458.7, CN03135691.5, CN03135701.6, CN02149368.5, CN200510059785. 0. Published patents of CN200410013725.0 and CN200510047701.1

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0266] Preparation:

[0267] (1) Add 6 times the amount of ginseng (the first time because it is a dry medicinal material, add 1 times more) 70% ethanol reflux extraction twice, each time for 2 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, and concentrate the liquid Each 1ml is equivalent to containing 1.45-1.55g of ginseng crude drug, add the same amount of water-saturated n-butanol for extraction 6 times each time, combine the n-butanol liquid, recover n-butanol until it has no n-butanol smell, dissolve it in water, and filter , to obtain the ginsenoside intermediate, for subsequent use;

[0268] (2) Add 9 times the amount of water to the red ginseng medicinal residue after alcohol extraction (the first time because it is a dry medicinal material, add 3 times the amount) decoction extraction or reflux extraction 3 times, each time for 2 hours, filter, and concentrate to The concentration of the medicinal solution is 0.75-0.85g cr...

Embodiment 2

[0285] Preparation:

[0286] Remarks: The preparation method of the prescription of similar preparations in this embodiment is the same.

[0287] (1) Add 6 times the amount of ginseng (the first time because it is a dry medicinal material, add 1 times more) 70% ethanol reflux extraction twice, each time for 2 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, and concentrate the liquid Each 1ml is equivalent to containing 1.45-1.55g of ginseng crude drug, add the same amount of water-saturated n-butanol for extraction 6 times each time, combine the n-butanol liquid, recover n-butanol until it has no n-butanol smell, dissolve it in water, and filter , to obtain the ginsenoside intermediate, for subsequent use;

[0288] (2) Add 9 times the amount of water to the red ginseng medicinal residue after alcohol extraction (the first time because it is a dry medicinal material, add 3 times the amount) decoction extraction or reflux extraction 3 ...

Embodiment 3

[0307] Preparation:

[0308] (1) Add 6 times the amount of ginseng (the first time because it is a dry medicinal material, add 1 times more) 70% ethanol reflux extraction twice, each time for 2 hours, filter, recover the ethanol from the filtrate until it has no alcohol smell, and concentrate the liquid Each 1ml is equivalent to containing 1.45-1.55g of ginseng crude drug, add the same amount of water-saturated n-butanol for extraction 6 times each time, combine the n-butanol liquid, recover n-butanol until it has no n-butanol smell, dissolve it in water, and filter , to obtain the ginsenoside intermediate, for subsequent use;

[0309] (2) Add 9 times the amount of water to the red ginseng medicinal residue after alcohol extraction (the first time because it is a dry medicinal material, add 3 times the amount) decoction extraction or reflux extraction 3 times, each time for 2 hours, filter, and concentrate to The concentration of the medicinal solution is 0.75-0.85g cr...

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Abstract

The present invention relates to a kind of medicine preparation with ginseng component and aconite root component and its preparation process and quality control method. Of the medicine preparation, each unit contains total ginsenoside in 1-90 mg, total ginseng polysaccharide in 2-282 mg, and total aconite root alkaloid in 0.02-22 mg. The medicine preparation may have other synergistic medicine component added. Its preparation process includes extracting the total ginsenoside, the total ginseng polysaccharide and the total aconite root alkaloid; adding supplementary material; and forming different preparation forms.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a pharmaceutical preparation containing ginseng and aconite as raw materials, a preparation method and a quality control method thereof. Background technique [0002] The ancient prescription "Shenfu Decoction" is composed of ginseng and aconite. According to the theory of traditional Chinese medicine, this prescription is a prescription for recovering yang, resuscitating adverse conditions, replenishing qi and solidifying qi, and it is mainly used clinically for juetuo syndrome of violent yang qi depletion. [0003] Ginseng contains saponins and polysaccharides; aconite contains alkaloids, mainly aconitum alkaloids; ester alkaloids are one of aconitum alkaloids and are poisonous. [0004] Currently, there are Shenfu injections on the market. At the same time, there are a number of published patents related to Shenfu injections and freeze-dried powder for i...

Claims

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Application Information

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IPC IPC(8): A61K36/714A61K31/715A61K9/08A61K9/14A61K9/16A61K9/19A61K9/20A61K9/48A61P1/14A61P43/00G01N30/92G01N30/02G01N21/31G01N33/15
Inventor 孙明珍艾劼刘路瞿冰
Owner 深圳市资福药业有限公司
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