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Health article or medicine prepared with acidophilic lactobacillus for preventing and treating chronic gastropathy

A technology for Lactobacillus acidophilus and chronic gastropathy, applied in dairy products, medical preparations containing active ingredients, antibacterial drugs, etc., can solve problems such as retention, and achieve the effect of preventing and treating chronic gastropathy

Inactive Publication Date: 2006-05-17
JILIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] However, it should be emphasized that the above-mentioned work so far has only remained in laboratory research, and no one has developed it into a probiotic preparation that can be used for the clinical eradication of H. .pylori-infected functional foods

Method used

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  • Health article or medicine prepared with acidophilic lactobacillus for preventing and treating chronic gastropathy
  • Health article or medicine prepared with acidophilic lactobacillus for preventing and treating chronic gastropathy
  • Health article or medicine prepared with acidophilic lactobacillus for preventing and treating chronic gastropathy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Preparation of Lactobacillus acidophilus strain

[0036] 1) Isolation, cultivation and identification of Lactobacillus acidophilus

[0037] Stool samples from healthy young people were isolated and cultured according to conventional methods, and it was confirmed that each strain of Lactobacillus acidophilus was obtained

[0038] 2) Screening of Lactobacillus acidophilus with anti-Helicobacter pylori activity

[0039] From the above Lactobacillus acidophilus strains, the Lactobacillus acidophilus strains that simultaneously meet the following anti-Helicobacter pylori characteristics are screened out by the following detection methods:

[0040] a. Tested by agar punching method, the diameter of the inhibition zone is greater than 2 cm;

[0041] b. Quantitative detection of Helicobacter pylori urease activity, the inhibition of Helicobacter pylori urease activity is greater than 50% within 2 hours;

[0042] c. Detection of Helicobacter pylori colony counting method, inhib...

Embodiment 2

[0046] Preparation of fermented milk and dairy products that can prevent and treat chronic stomach diseases:

[0047] Fresh milk is sterilized by heat (generally at 90°C for 30 minutes), after homogenization, it is lowered to a suitable temperature (40-50°C), added sugar and stabilizer, stirred evenly, and inoculated with Lactobacillus acidophilus 10 11 ~10 12 CFU / ml, ferment at 37°C for 12-24 hours, and when the pH value reaches 3.5-5.5, place it in a cold storage at about 4°C to cool and mature to obtain the finished product.

[0048] Apply the Hp infection experimental animal model established by the method of gavage Helicobacter pylori bacterium liquid (standard strain NCTC11637CagA+ and CagA+ clinical isolate) to mice (BALB / C mice and C57 / BL6 mice), carry out the contrast of adopting the product treatment of the present invention experiment:

[0049] The present invention can prevent and treat chronic gastropathy by feeding mice infected with Helicobacter pylori, once a...

Embodiment 3

[0051] Preparation of yogurt that can prevent and treat chronic stomach disease:

[0052] Soybeans are pre-treated by blanching, soaking, and grinding to obtain soymilk. Add milk powder, sucrose or lactose and other auxiliary materials to the soybean milk, after homogenization and sterilization, cool to a suitable temperature (40-50°C), and inoculate the Lactobacillus acidophilus 10 selected by the above steps 11 ~10 12 CFU / ml for fermentation. After the fermentation is over, put it in a cold storage at 4°C to cool, and carry out post-fermentation to obtain the finished product.

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PUM

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Abstract

The present invention relates to the new use of acidophilic lactobacillus in preparing functional food and medicine, and is especially health article and medicine for preventing and treating chronic gastropathy prepared with acidophilic lactobacillus. Acidophilic lactobacillus with specific pyloric helicobacter antagonizing effect is cultured, separated and screened from human gastrointestinal tract excrement, and inoculated to food or medicine acceptable carrier. The acidophilic lactobacillus has the specific pyloric helicobacter antagonizing characteristics of bacteriostasis ring diameter detected via agar perforating process greater than 2 cm, pyloric helicobacter urease inhibiting activity in 2 hr greater than 50 % and 4 hr inhibition of pyloric helicobacter growth greater than 1 LgCFU / ml. Taking the health article or medicine of the present invention can preventing and treating chronic gastropathy caused by pyloric helicobacter infection.

Description

technical field [0001] The invention relates to the new application of Lactobacillus acidophilus in functional food and pharmacy, that is, using Lactobacillus acidophilus to prepare health products or medicines capable of preventing and treating chronic stomach diseases. Background technique [0002] Chronic gastritis and peptic ulcer are frequently-occurring diseases worldwide, but the prevalence varies in different countries and regions. It is generally believed that the prevalence in developing countries is significantly higher than that in developed countries. A recent survey in Europe shows that the infection rate of Helicobacter pylori (H. pylori) in the population is 40%-70%. After H.pylori infection, it is generally difficult for the body to clear it by itself, so the infection will cause gastric mucosal inflammation without exception. Therefore, the prevalence of chronic gastritis in the population is roughly equal to the infection rate of H.pylori. There is still ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23C9/12A23G3/00A61K9/08A61K9/10A61K9/14A61K9/48A61K35/747A61P1/04A61P31/04
Inventor 王江滨焦健李岩张学英
Owner JILIN UNIV
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