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Method for preparing dripping pills of Onidazole

The technology of ornidazole dropping pills and ornidazole, which is applied in the field of oral pharmaceutical composition preparations, can solve the problems of immature preparation technology of dropping pills, increase the cost of medication for patients, affect the accuracy of medication dosage, and the like, so as to improve bioavailability. The effect of high degree of safety, medication safety, and high roundness rate

Inactive Publication Date: 2006-03-29
北京博智绿洲医药科技有限公司
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AI Technical Summary

Problems solved by technology

[0006] Yet, because the preparation technology of drop pill is not yet very mature, and its related equipment has not yet reached the degree of standardization, when utilizing existing technology to prepare drop pill, product quality is affected by the physicochemical property of medicine, the kind of matrix and its mixing with medicine. Influenced by factors such as ratio, condensing agent and its temperature, indicators such as rounding rate and difference in pill weight are quite different from the quality indicators of dripping pill preparations stipulated in the national drug standards. Such products seriously affect the dosage in use. The accuracy of the product also reduces the qualified rate of the product in production, increases the production cost, and indirectly increases the drug cost of the patient, thus reducing its practicability

Method used

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  • Method for preparing dripping pills of Onidazole

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Embodiment Construction

[0031] Now with several groups of specific examples, the preparation method of ornidazole dropping pills of the present invention is further described.

[0032] [recipe selection]

[0033] 1. Drug raw material: Ornidazole

[0034] 2. Single matrix: selected from polyethylene glycol 1000 , polyethylene glycol 4000 , polyethylene glycol 6000 , polyethylene glycol 10000 , polyethylene glycol 20000, Span 40, polyoxyl 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac and other carriers;

[0035] 3. Combination matrix: take g or kg as the unit, by weight, choose polyethylene glycol, polyoxyl 40 stearate, sodium carboxymethyl starch, beta cyclodextrin, Tween and other carriers for combination test;

[0036] 3.1 The combination of two different substrates: take g or kg as the unit, by weight, take 1 part of polyoxyl 40 stearate or beta cyclodextrin or sodium carboxymethyl starch or Tween, and 1 part ~10 parts of polyethylen...

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Abstract

A dripping fill of ornidazole for suppressing and killing amebas, trichomonad and anaerobic bacteria is prepared from ornidazole and medicinal carrier. Its preparing process is also disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical composition for resisting amoeba, trichomonas and anaerobic bacteria, in particular to an oral preparation of a pharmaceutical composition prepared from ornidazole as a raw material. Background technique [0002] Ornidazole is the third-generation nitroimidazole derivative after metronidazole and tinidazole, and has good anti-anaerobe and anti-biotic (such as trichomonas, etc.) infection effects. It exerts antimicrobial effect through the reduction of nitro group in its molecule to amino group in anaerobic environment or through the formation of free radicals, interacting with cell components, resulting in the death of microorganisms. It can be widely used in the treatment of various diseases caused by infections such as anaerobic bacteria, amoeba, giardia and trichomonas. Common clinical infectious diseases in gynecology include bacterial vaginosis, trichomoniasis, pelvic inflammatory disease, candidal vagini...

Claims

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Application Information

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IPC IPC(8): A61K31/4164A61K9/20A61P33/02
Inventor 曲韵智徐俊福
Owner 北京博智绿洲医药科技有限公司
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