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Itraconazole dripping pill and its prepn

A technology of itraconazole and azole dropping pills is applied in the directions of pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve the problems of unfavorable improvement of patients' ability to seek medical treatment, low bioavailability and high production cost, Achieve the effects of improved bioavailability, faster dissolution and absorption, and lower production costs

Inactive Publication Date: 2007-10-10
北京博智绿洲医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Due to the preparation technology and other reasons, the oral preparations of most drugs, especially the oral preparations of traditional Chinese medicine, have problems such as long dissolution time, low dissolution rate, poor absorption, hepatic and intestinal first-pass effect and low bioavailability after taking. , thus affecting the efficacy of the drug and directly affecting the therapeutic effect
In addition, conventional oral dosage forms, such as tablets, capsules, granules (infusions), etc., due to the granulation process in the preparation process, will generate relatively large dust pollution, which will cause health problems to the staff to a certain extent. harm, and also cause some pollution to the environment
Although injections overcome the disadvantages of low bioavailability of conventional oral preparations, they have the disadvantages of prone to allergic reactions, inconvenient use, and great pain for patients
Furthermore, the production process of conventional oral preparations and injections is complicated and the production cost is high, so that the cost of medication for patients is also increased, which is not conducive to improving the ability of patients to seek medical treatment, and is also not conducive to improving the overall health level of society

Method used

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  • Itraconazole dripping pill and its prepn

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0036] Several specific examples are now used to further illustrate the preparation method of itraconazole dripping pills of the present invention.

[0037] [Selection of formula]

[0038] 1. Raw material: itraconazole

[0039] 2. Single substrate: selected from polyethylene glycol 1000 Polyethylene glycol 4000 Polyethylene glycol 6000 Polyethylene glycol 10000 Polyethylene glycol 20000 , Span 40, Polyoxy 40 stearate, poloxamer, sodium lauryl sulfate, stearic acid, sodium stearate, glycerin gelatin, shellac and other carriers;

[0040] 3. Combination base: in g or kg, by weight, select polyethylene glycol, polyoxy 40 stearate, sodium carboxymethyl starch, beta cyclodextrin, Tween and other carriers for combination test;

[0041] 3.1 Combination of two different substrates: take 1 part of polyoxyl 40 stearate or beta cyclodextrin or sodium carboxymethyl starch or Tween in units of g or kg by weight, and 1 part ~10 parts of polyethylene glycol in combination, where polyethylene glyc...

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Abstract

The present invention discloses one kind of orally taken antifungal medicine composition, and aims at providing one kind of antifungal itraconazole dripping pill with high bioavailability, fast medicine release, fast acting, high medicine content, easy taking, low cost and production process without pollution. The itraconazole dripping pill is prepared with itraconazole as medicine material and medicine carrier as matrix.

Description

Technical field [0001] The invention relates to a pharmaceutical composition with an antifungal effect, in particular to a triazole antifungal oral preparation prepared by using itraconazole as a raw material. Background technique [0002] Itraconazole is a triazole antifungal drug with a broad antibacterial spectrum and good tolerance. Its main metabolite hydroxyitraconazole also has high antifungal activity. Itraconazole capsules have been in clinical use for many years, mainly for the treatment of superficial fungal infections. In the treatment of more serious systemic fungal infections, a higher stable blood concentration is required, but itraconazole capsules cannot be absorbed. According to the rules, the blood drug concentration fluctuates greatly, which limits its application. Since 1992, oral solutions and intravenous injections have been developed abroad. These preparations combine itraconazole with hydroxypropyl β cyclodextrin (consisting of 6 glucose molecules, throug...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/496A61K9/20A61P31/10
Inventor 曲韵智
Owner 北京博智绿洲医药科技有限公司
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