A kind of sildenafil dripping pill

Abstract

The invention relates to a sildenafil dropping pill, which is made of the following raw materials in weight percentage: 5-50% of sildenafil; 20-70% of a matrix, 0.1-20% of auxiliary materials that can increase cohesion, and improve dropping pills Properties and bioavailability-enhancing excipients 0-20%. The dropping pill has the function of treating erectile dysfunction.

Description

Technical field: [0001] The invention relates to a pharmaceutical preparation of chemical medicine and its preparation, in particular to a sildenafil dropping pill and its preparation. Background technique: [0002] Sildenafil citrate (sildenafil for short) is an oral drug for the treatment of erectile dysfunction (ED). It is the citrate salt of sildenafil, a selective inhibitor of phosphodiesterase type 5 (PDE5) specific for cyclic guanosine monophosphate (cGMP). Mechanism of action: The physiological mechanism of penile erection involves the release of nitric oxide (NO) in the corpus cavernosum during sexual stimulation. The activation of guanylate cyclase by NO leads to an increase in the level of cyclic guanosine monophosphate (cGMP), which relaxes the smooth muscle in the cavernous body and fills the blood. Sildenafil citrate is a white to off-white crystalline powder with a very bitter taste. Its marketed dosage form, Sildenafil Citrate Tablets, is a special oral dr...

AI Technical Summary

Problems solved by technology

The excipients disclosed in the disclosed examples also have the problems of low drug loading or difficulty in dripping pills, and poor pill shape.

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