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Anti-blood coagulation surface modifying method of artificial implant

A surface modification and implant technology, applied in the field of anticoagulant materials, can solve the problems of reducing the flexibility of artificial blood vessels, insufficient anticoagulant performance, and poor stability, so as to improve anticoagulant performance and overcome insufficient stability of performance , the effect of avoiding damage

Inactive Publication Date: 2006-03-22
HARBIN INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The purpose of the present invention is to reduce the flexibility of artificial blood vessels and the anticoagulant performance is not good enough for hard-linked heparin, the concentration of covalently bonded monolayer heparin is too low, and the electrostatic attraction layer-by-layer self-assembly technology has ion-bonded The disadvantage of poor stability of molecular membranes in polar solvents provides an anticoagulant surface modification method for artificial implants. This method uses silicone rubber coatings as soft supports to assemble diazo resin and heparin multilayer membranes, which is sufficient Utilizing the simplicity of layered electrostatic assembly, combined with the photochemical reaction of diazo groups and sulfuric acid groups in the film, the ionic bonds in the film are converted into covalent bonds, so that the heparin multilayer film Greatly improved stability

Method used

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  • Anti-blood coagulation surface modifying method of artificial implant
  • Anti-blood coagulation surface modifying method of artificial implant
  • Anti-blood coagulation surface modifying method of artificial implant

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specific Embodiment approach 1

[0017] Specific Embodiment 1: This embodiment is achieved in the following way: a. Soak the artificial implant in an organic solvent, ultrasonically clean it for 30 to 120 minutes, and then dry it at 30 to 90°C for 0.5 to 2 hours; b. Medical silicone rubber is used as a room temperature curing adhesive, which is dissolved in an organic solvent to prepare a silicone rubber solution; c. Coating medical silicone rubber on the inner surface of the artificial implant as a soft support; d. Coating the silicone rubber coated with perfluorosulfonic acid on the surface; e, positively charged polycations and negatively charged polyanions are alternately deposited on the surface of perfluorosulfonic acid coating through electrostatic attraction; f, artificially irradiated with ultraviolet light Implanted into the inner wall of the body, the ionic bonds between the inner layers of the membrane are converted into covalent bonds through photochemical reactions, and an anticoagulant surface u...

specific Embodiment approach 2

[0023] Specific implementation mode two: this implementation mode is realized in this way:

[0024] 1) Cleaning the artificial blood vessel: Soak the expanded polytetrafluoroethylene artificial blood vessel in an organic solvent, sonicate for 30-120 minutes, and then dry it at 30-90° C. for 0.5-2 hours.

[0025] 2) Dissolving the silicone rubber: dissolving the medical silicone rubber as a room temperature curing adhesive in an organic solvent to prepare a silicone rubber solution with a volume concentration of 0.1-100v / v%.

[0026] 3) Silicone rubber coating: connect the artificial blood vessel to the syringe, erect it, and then use the syringe to inject the silicone rubber solution into the lumen of the artificial blood vessel from the end until the lumen is filled. Then remove the silicone rubber solution from the end of the artificial blood vessel with a syringe, and dry it in the air at room temperature for 2 to 100 hours.

[0027] 4) Soak the silicone rubber coating: seal...

specific Embodiment approach 3

[0040] Specific implementation mode three: this implementation mode is realized in this way:

[0041] a. Soak the expanded polytetrafluoroethylene artificial blood vessel in absolute ethanol, sonicate for 30 minutes, and then dry at 60° C. for 1 hour.

[0042] b. Using medical silicone rubber as a room temperature curing adhesive, dissolve it in an organic solvent to prepare a 50v / v% silicone rubber solution;

[0043] c. Connect the artificial blood vessel to the syringe, stand it upright, and then use the syringe to inject 50v / v% silicone rubber solution into the lumen of the artificial blood vessel from the end until the lumen of the artificial blood vessel is filled. The silicone rubber solution was removed and dried in air at room temperature for 24 hours. Clamp the end of the artificial blood vessel with clips, fill the lumen with absolute ethanol, and let it stand for 2 hours.

[0044] d. Remove the ethanol, and inject 5wt% Nafion solution from the end of the artificia...

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Abstract

The present invention belongs to the field of anticoagulant material technology. The anticoagulant surface modification process of artificial implant includes the following steps: cleaning artificial implant; preparing silicone rubber solution; coating the artificial implant with medical silicone rubber as support; coating perfluoro sulfonic acid on the surface of the silicone rubber coating; depositing polycation and polyanion alternately onto the surface of the perfluoro sulfonic acid coating via electrostatic attraction; and irradiating the artificial implant with ultraviolet light to produce photochemical reaction to convert the ionic bond between coating layers into covalent bond. The present invention has simple technological process, mild reaction condition, easy operation, high repeatability, environment friendship and thus excellent application foreground.

Description

Technical field: [0001] The invention belongs to the technical field of anticoagulant materials, and relates to a method for modifying an artificial implant with a silicon rubber coating as a soft support and covalently bonding a multilayer heparin film so that the surface has anticoagulant performance. Background technique: [0002] In small-caliber artery reconstruction surgery, the blood compatibility requirements for arterial prostheses are very high. In order to ensure long-term patency after surgery, autologous saphenous vein is usually used as arterial prosthesis. However, when the patient cannot provide an autologous saphenous vein, artificial blood vessels must be used instead. Although expanded polytetrafluoroethylene has been successfully used in the manufacture of larger diameter blood vessels, for blood vessels with diameters less than 6mm, these materials are powerless due to blood clotting or tissue blockage. Although the long-term patency rate has been impr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L33/00
Inventor 戴志飞岳秀丽
Owner HARBIN INST OF TECH
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