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Flavone hippophaes drop pills and method for preparing the same

A technology of acetaloflavone and dripping pills, which is applied in pill delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc. It can solve the problem of large differences in pill weight, quality indicators, low rounding rate of qualified products, and influence on drug use. Dosage accuracy and other issues, to achieve the effects of small differences in pill weight, safe medication, and improved bioavailability

Inactive Publication Date: 2006-02-08
COSCI MED TECH CO LTD
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  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

[0008] The Chinese invention patent with the application number 03157888.8 discloses a kind of acetaloflavone dripping pills in its disclosed description, but the dripping pill preparations prepared according to the preparation method disclosed in the above-mentioned prior art, in the test, its circle The qualified product rate of the whole rate is low, and the difference in pill weight is also quite different from the quality indicators of the relevant drop pill preparations stipulated in the national drug standards. Such products have a strong impact on the accuracy of the dosage in use. It also reduces the qualification rate of the product, increases the production cost, and indirectly increases the drug cost of the patient, thus reducing its practicability.

Method used

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Examples

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Embodiment Construction

[0029] Now with several groups of specific examples, the preparation method of acetaloflavone dripping pills of the present invention will be further described.

[0030] [Test prescription]

[0031] 1. Raw material - acetaloflavone

[0032] 2. Base—a mixture of polyoxyl 40 stearate and polyethylene glycol, as follows:

[0033] 2.1 Polyoxyl 40 stearate: polyethylene glycol 2000 =1:1~1:10

[0034] 2.2 Polyoxyl 40 stearate: polyethylene glycol 4000 =1:1~1:10

[0035] 2.3 Polyoxyl 40 stearate: polyethylene glycol 6000 =1:1~1:10

[0036] 2.4 Polyoxyl 40 stearate: polyethylene glycol 10000 =1:1~1:10

[0037] 2.5 Polyoxyl 40 stearate: polyethylene glycol 20000 =1:1~1:10

[0038] 3. The ratio of acetaloflavone and matrix:

[0039] In g or kg as the unit, acetaloflavone: matrix = 1:1~1:9

[0040] 4. Prepare according to the process given in [Preparation Method] 4-7, and you can get aceflavone dripping pills with different specifications.

[0041] [Test content and results] ...

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Abstract

The invention relates to a Culiuhuangtong drip pill composition for treating heart diseases and hyperlipemia, which has the advantages of high biological availability, quick-speed medicine release, quick-speed effect, higher medicinal content, accurate quantitative determination, easy administration, low price, and causing no pollution during production. The drop pill is prepared from polyethylene glycol, polyoxyl (40) stearate as the base material, and Culiuhuangtong as the raw material.

Description

technical field [0001] The invention relates to a pharmaceutical composition for treating heart disease and hyperlipidemia, in particular to an oral preparation of a pharmaceutical composition prepared from acetaloflavone as a raw material. Background technique [0002] Seabuckthorn (Hippophaerhamnoides L) is a plant of the family Echinacea, and the northeast, north, northwest and southwest of China are the main distribution areas of Hippophae hamnoides. It is rich in vitamins, various trace elements, various amino acids and fatty acids, as well as flavonoids, triterpenes and steroidal compounds. Seabuckthorn fruits and leaves contain flavonoids, and the total content of flavonoids in leaves is higher than that in fruits. The flavonoid compounds that have been identified include: quercetin, isorhamnetin, kaempferol and its glycosides, myricetin, chlorogenic acid, hygroside, catechol and astragaloside, etc. At present, the flavonoid compound extracted from seabuckthorn - ac...

Claims

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Application Information

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IPC IPC(8): A61K31/352A61K31/7048A61K9/20A61P3/06A61P9/00
Inventor 王锦刚
Owner COSCI MED TECH CO LTD
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