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Compound aspirin tading kind medicinal preparation and its application

A technology of aspirin and medicine, which is applied in compound aspirin statin drug preparations and its application field, and can solve problems such as stimulation reactions

Inactive Publication Date: 2005-08-10
FUKANGREN BIO PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the obvious side effects in this study were gastrointestinal irritation, including nausea, vomiting, acid regurgitation, etc.

Method used

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  • Compound aspirin tading kind medicinal preparation and its application
  • Compound aspirin tading kind medicinal preparation and its application
  • Compound aspirin tading kind medicinal preparation and its application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] Embodiment 1: prepare common tablet

[0045] Element

[0046] Preparation method: the drug and auxiliary materials are passed through 80 mesh sieves, aspirin, lovastatin, clofibrate, aluminum glycolate, heavy magnesium carbonate, microcrystalline cellulose, cross-linked carboxymethyl cellulose (2 / 3), Mix well, use 5% povidone 95% ethanol solution to make soft material, sieve, dry, granulate, add remaining 1 / 3 cross-linked carboxymethyl cellulose, magnesium stearate, micropowder silica gel, mix well, directly Tablets, ready to use.

Embodiment 2

[0047] Embodiment 2: Preparation of enteric-coated tablets

[0048] According to Example 1, 1000 ordinary compound aspirin tablets were prepared and coated with an enteric coating material.

[0049] prescription:

[0050] 1000 tablets

[0051] Hydroxypropyl Methyl Cellulose Phthalate 21g Coating Polymer

[0052] Ethylcellulose 3.6g Film coating aid

[0053] Ethanol 130ml organic solvent

[0054] Acetone 130ml organic solvent

[0055] Coating with a coating pan

[0056] Operating conditions:

[0057] Coating pan speed 6~7r / min

[0058] Spray Type Airless Spray

[0059] Nozzle size 0.4mm nozzle (60° angle)

[0060] Spray speed 100ml / min

[0061] Liquid pressure 52~80kg / cm 2

[0062] Exhaust velocity 140~160m 3 / min

[0063] Intake air velocity 130~150m 3 / min; 20℃

[0064] 40%~60% relative humidity

[0065] Coating time 45min

[0066] Tablet weight increased by about 5% after coating.

Embodiment 3

[0068] Element

[0069] Preparation method: pass through 80-mesh sieve respectively for the drug and auxiliary materials, mix aspirin, fluvastatin, gemfibrozil, aluminum glycolate, heavy magnesium carbonate, microcrystalline cellulose, and cross-linked carboxymethyl cellulose evenly, and use 5% povidone 75% ethanol solution to make soft materials, sieve, dry, granulate, add talcum powder, mix well, put into capsule shell.

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PUM

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Abstract

A compound aspirin-tatin medicnie contains proportionally aspirin, the medicine in tatin kind, hypolipemic medicine, dihydroxyaluminium aminoacetate, heavy magnesium carbonate or magnesium aluminate carbonate, skeleton and medical auxiliary. Its application is also disclosed.

Description

Technical field: [0001] The present invention relates to a compound pharmaceutical composition, in particular to 5mg-150mg of aspirin, 1mg-150mg of statins, 10-800mg of triglyceride-lowering drugs, 5-22mg of aluminum glyoxate, 11-44mg of weight A pharmaceutical preparation consisting of magnesium carbonate or 15-150 mg hydrotalcite and other magnesium-aluminum preparations, an appropriate amount of skeleton material, and an appropriate amount of pharmaceutically acceptable excipients. Background technique: [0002] Small doses of aspirin can inhibit the platelet release response (release caused by adrenaline, collagen, thrombin, etc.) and aggregation reaction (second phase aggregation). It can prolong bleeding time and reduce thrombus formation in vivo. Simultaneous inhibition of cholesterol biosynthesis reduces normal and elevated low-density lipoprotein cholesterol (LDL-C) levels. Statins reduce cholesterol synthesis by inhibiting HMG-CoA reductase. Clofibrate derivativ...

Claims

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Application Information

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IPC IPC(8): A61K31/616A61K45/06A61P3/06A61P7/02A61P9/10
Inventor 鄂滟蔡金巧
Owner FUKANGREN BIO PHARMA
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