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Orally disintegrating tablet of safflor yellow and its preparation process

A technology of safflower yellow and disintegrant, which is applied in the field of safflower yellow orally disintegrating tablets, can solve problems such as difficult operation, heavy financial burden on patients, and difficulty in taking it

Inactive Publication Date: 2005-04-06
COSCI MED TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Due to the dosage form, most oral preparations need to be taken with a lot of water, which makes it difficult for many elderly people, infants, or patients with difficulty swallowing and inconvenient water intake.
Injections are often prone to allergic reactions or adverse reactions, etc. At the same time, injections also have the disadvantages of difficult operation, great pain for patients, high manufacturing and medical costs, and heavy economic burden for patients.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment one direct flavoring method

[0033] 1. Prescription

[0034] 1. Raw material - 30.0g of safflower yellow pigment;

[0035] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;

[0036] 3. Filling agent - mannitol 48.5g;

[0037] PROSOLV  SMCC 5.0g;

[0038] 4. Flavoring agent - aspartame 1.0g;

[0039] Ginseng essence 1.0g;

[0040] 5. Disintegrant—cross-linked polyvinylpyrrolidone 8.0g;

[0041] L-HPC 4.0g;

[0042] 6. Glidant - micropowder silica gel 1.0g;

[0043] 7. Lubricant—sodium stearyl fumarate 1.0 g.

[0044] The total weight is 100g, and a total of 1000 pieces are made.

[0045] 2. Preparation method

[0046] 1) Take the safflower yellow raw material and pulverize it, granulate it with polyvinylpyrrolidone K-30, pass it through a 26-mesh sieve, and set aside;

[0047] 2) Micropowder silica gel, ginseng essence, PROSOLV  SMCC and aspartame were passed through a 40-mesh sieve, mixed evenly, and then the granulated safflower yellow granules w...

Embodiment 2

[0050] Embodiment two powder coating taste masking method

[0051] 1. Prescription

[0052] 1. Raw material - 30.0g of safflower yellow pigment;

[0053] 2. Coating material - Eudragit  E100 3.5g;

[0054] Eudragit  NE30D (dry) 1.5g;

[0055] 3. Filling agent - mannitol 55.5g;

[0056] Microcrystalline cellulose 5.0g;

[0057] 4. Flavoring agent - aspartame 1.0g;

[0058] Ginseng essence 1.0g;

[0059] 5. Disintegrant—cross-linked polyvinylpyrrolidone 6.0g;

[0060] L-HPC 4.0g;

[0061] 6. Glidant - micronized silica gel 1.5g;

[0062] 7. Lubricant—sodium stearyl fumarate 1.0 g.

[0063] The total weight is 110g, and a total of 1000 pieces are made.

[0064] 2. Preparation method

[0065] 1) Take Eudragit  E100 and Eudragit  NE30D Eudragit  NE30D is dissolved with more than 95% pharmaceutical industrial ethanol and diluted to a certain concentration for later use;

[0066] 2) Take the safflower yellow pigment and boil it in a fluidized bed, spray the above ...

Embodiment 3

[0069] Embodiment three effervescent agent flavoring method

[0070] 1. Prescription

[0071] 1. Raw material - 30.0g of safflower yellow pigment;

[0072] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;

[0073] 3. Effervescent agent - citric acid 12.5g;

[0074] Sodium bicarbonate 10.0g;

[0075] 4. Filling agent - mannitol 43.0g;

[0076] PROSOLV  SMCC 5.0g;

[0077] 5. Flavoring agent - aspartame 1.0g;

[0078] Orange essence 1.0g;

[0079] 6. Disintegrant—cross-linked polyvinylpyrrolidone 10.0g;

[0080] L-HPC 5.0g;

[0081] 7. Glidant - micropowder silica gel 1.0g;

[0082] 8. Lubricant—1.0 g of sodium stearyl fumarate.

[0083] The total weight is 120g, and a total of 1000 pieces are made.

[0084] 2. Preparation method

[0085] 1) Take safflower yellow pigment and citric acid raw materials, mix them, pulverize them, granulate them with polyvinylpyrrolidone K-30, pass through a 26-mesh sieve, and set aside;

[0086] 2) Take sodium bicarbonate and pulverize ...

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Abstract

The invention relates to a disintegrated tablet of carthamin yellow carthamus with functions like dilation of the coronary arteriae, antioxidation, tomyocardium protection, blood pressure decrease, immunodepression and brain protection and its preparing technique. It is aiming at advancing the present the preparation kind of carthamin yellow carthamus, supplying a disintegrated tablet of carthamin yellow carthamus with convenient use and rapid effect and its preparing technique. Using carthamin yellow carthamus as raw material, bulking agent, disintegrating agent, taste reclaiming agent, glidant and lubricant as auxiliary materials, and adding into suitable quantity of effervescent granules or using adhesives or packaging material in accordance with different condition, through the special preparing method, use tablet press to acquire the product. The invention has rapid, good taste, without feeling like sand in mouth, does not need special producing condition; it has characteristics like low cost, convenient storage, transportation and disintegration, especially, it can be disintegrated without drinking water and conformity has rapid effect, advancing sicker's conformity and increasing medicine curative effect.

Description

[technical field] [0001] The invention relates to a safflower yellow orally disintegrating tablet with the functions of expanding coronary artery, anti-oxidation, protecting myocardium, lowering blood pressure, immunosuppression and brain protection. [Background technique] [0002] Safflower is a commonly used drug for promoting blood circulation and removing blood stasis, which can be used for the treatment of many blood circulation disorders such as coronary heart disease and angina pectoris. Safflower yellow is the effective part extracted from the traditional Chinese medicine safflower (commonly known as grass safflower), which is the main water-soluble component of safflower, and is a mixed chalcone glycoside. It can treat or prevent a variety of cardiovascular and cerebrovascular diseases and other blood circulation disorders. Crude safflower yellow pigment is a food pigment allowed by the country and has been on the market for more than ten years. Safflower yellow h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/352A61P9/10A61P9/12A61P25/00A61P37/02
Inventor 蒋海松王红喜王锦刚
Owner COSCI MED TECH CO LTD
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