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Sucking tablet for promoting liver cell to growth

A technology of hepatocyte auxin and buccal tablets, which is applied in the field of pharmaceutical preparations for oral absorption, can solve the problems of destroying biological activity, inconvenient long-term use of chronic patients, and affecting the treatment effect, achieving good stability and absorption Easy-to-use, easy-to-absorb effect

Inactive Publication Date: 2005-02-16
FUJIAN COSUNTER PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Hepatocyte growth factor (HGF) is effective in treating hepatitis, liver injury and liver fibrosis. Since HGF is taken orally, its biological activity will be destroyed by digestive enzymes, which will affect the therapeutic effect. At present, the clinically used HGF is injection. It is inconvenient for patients, especially chronic patients, to use it for a long time

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1. Get 4 grams of HGF dry powder, 10 grams of lysine, 900 grams of lactose, 380 grams of powdered sugar, 1000 grams of starch slurry (17%).

[0017] First mix HGF and lysine with 50 grams of lactose and set aside. Mix 850 grams of lactose, 380 grams of powdered sugar and 1000 grams of starch slurry evenly, granulate, dry, and make blank granules, then mix the HGF mixture and blank granules thoroughly, and press into tablets. , so that the weight of each piece is 0.5-0.8 grams, it can be tested and packaged.

Embodiment 2

[0018] Embodiment 2. add 70 gram menthols in the composition of embodiment 1, earlier menthol and lactose, powdered sugar, starch slurry are made blank granules, then mix the mixture tabletting with HGF, lysine and lactose, Promptly make the HGF buccal tablet of peppermint taste.

Embodiment 3

[0019] Embodiment 3. Get 10 grams of HGF dry powder, 15 grams of arginine, 80 grams of sodium lauryl sulfate, 1500 grams of starch, 210 grams of dextrin, 220 grams of powdered sugar, 0.02M phosphate buffer solution (PH=5.5) 800 ml.

[0020] First, dissolve HGF dry powder, arginine, and sodium lauryl sulfate in 800 ml of phosphate buffer solution to make a mixed solution, mix well and set aside. Then mix starch, dextrin and powdered sugar into a uniform powder, then spray the mixed solution on the mixed powder, stir evenly, granulate, dry at low temperature and then compress into tablets.

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PUM

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Abstract

The invention is an oral medicine tablet for advancing liver cell growth. Its ingredients and contents are: liver cell growth advancing element 0.05-15%, filler 50-99.9%, stabilizer 0.05-30%, absorption advancer 0-30%, taste modifier 0-20%, pH value buffer 0-25%, HGF element in the oral tablet has a good stability, the taste is well, and it is convenient, and it is easy to be absorbed by mouth mucous.

Description

technical field [0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical preparation for oral absorption of hepatocyte growth-stimulating factor. Background technique [0002] Hepatocyte Growth Factor (HGF) is a polypeptide substance that can stimulate DNA synthesis in hepatocytes, also known as hepatocyte growth factor, hepatocyte growth stimulating factor, etc., usually obtained from animal liver (such as milk Pig liver) extraction and genetic engineering recombination method to produce. Hepatocyte growth factor (HGF) is effective in treating hepatitis, liver injury and liver fibrosis. Since HGF is taken orally, its biological activity will be destroyed by digestive enzymes, which will affect the therapeutic effect. At present, the clinically used HGF is injection. It is very inconvenient for patients, especially chronic patients, to use for a long time. Contents of the invention [0003] The object of the present invention is to...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K38/18A61P1/16A61P31/12
Inventor 杨喜鸿
Owner FUJIAN COSUNTER PHARMA
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