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Oral disintegration tablets contg. p-acetaminophenol, and prepn. method therefor

A technology of acetaminophen and orally disintegrating tablets, which is applied in medical formulas, medical preparations containing active ingredients, pill delivery, etc., can solve problems such as difficulty in swallowing patients, inconvenient taking, and high hardness of tablets, and achieve Improve bioavailability, easy to take, and accelerate absorption

Inactive Publication Date: 2005-01-05
CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, most of the oral preparations need to be taken with water or the tablets are very hard, which will be difficult for patients with difficulty swallowing or inconvenient to take water, and it is also very inconvenient for children to take by themselves in schools or kindergartens, so these existing dosage forms are still available. Cannot fully meet the needs of patients

Method used

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  • Oral disintegration tablets contg. p-acetaminophenol, and prepn. method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Embodiment 1: Preparation of acetaminophen orally disintegrating tablets

[0046] formula:

[0047] Component Weight Weight %

[0048] Acetaminophen 100g 24%

[0049] Mannitol 160g 38.4%

[0050] Aspartame 1.2g 0.28%

[0051] Sodium bicarbonate 5g 1.2%

[0052] Citric Acid 5.7g 1.37%

[0053] Microcrystalline Cellulose 120g 28.8%

[0054] Polyvinylpyrrolidone (PVPP) 20g 4.8%

[0055]Flavor 0.8g 0.2%

[0056] Talc 4g 0.96%

[0057] Total weight 416.7 grams

[0058] A total of 1000 pieces were made

[0059] Preparation Process:

[0060] Weigh acetaminophen, mannitol, and aspartame according to the prescription amount, stir and mix well, use 50% ethanol aqueous solution (V / V) to make a soft material, pass through a 32-mesh sieve to granulate, dry at 50°C, press Prescription weighs additional auxiliary materials sodium bicarbonate, citric acid, microcrystalline cellulose, polyvinylpyrrolidone (PVPP), essence, talcum powder, mixes evenly, and compresses tablets. ...

Embodiment 2

[0061] Example 2: Preparation of acetaminophen orally disintegrating tablets

[0062] formula:

[0063] Component Weight Weight %

[0064] Acetaminophen 100g 20%

[0065] Erythrose 240g 47.9%

[0066] Cyclamate 7.2g 1.44%

[0067] Sodium bicarbonate 5 g 1%

[0068] Citric Acid 5.7g 1.1%

[0069] Microcrystalline Cellulose 98g 19.57%

[0070] Low-substituted hydroxypropyl cellulose (L-HPC) 40g 7.98%

[0071] Flavor 0.8g 0.16%

[0072] Talc 4g 0.8%

[0073] Total weight 500.7 grams

[0074] A total of 1000 pieces were made

[0075] Preparation Process:

[0076] Weigh acetaminophen, erythrose, cyclamate, and microcrystalline cellulose (half the amount) according to the prescription, stir and mix well, use 50% ethanol aqueous solution (V / V) to make a soft material, and pass through a 32-mesh sieve Granules, dried, weighed according to the prescription plus excipients sodium bicarbonate, citric acid, microcrystalline cellulose, low-substituted hydroxypropyl cellulose (L...

Embodiment 3

[0077] Embodiment 3: Preparation of acetaminophen orally disintegrating tablets

[0078] formula:

[0079] Component Weight Weight %

[0080] Acetaminophen 100g 24.8%

[0081] Erythrose 140g 34.76%

[0082] Cyclamate 7.2g 1.79%

[0083] Sodium bicarbonate 5g 1.24%

[0084] Citric Acid 5.7g 1.42%

[0085] Microcrystalline Cellulose 120g 29.8%

[0086] Low Substituted Hydroxypropyl Cellulose (L-HPC) 20g 5%

[0087] Flavor 0.8g 0.2%

[0088] Talc 4g 0.99%

[0089] Total weight 402.7 grams

[0090] A total of 1000 pieces were made

[0091] Preparation Process:

[0092] Weigh acetaminophen, erythrose, and cyclamate according to the prescription amount, stir and mix evenly, use 50% ethanol aqueous solution (V / V) to make a soft material, pass through a 32-mesh sieve to granulate, dry, and weigh according to the prescription Add excipients sodium bicarbonate, citric acid, microcrystalline cellulose, low-substituted hydroxypropyl cellulose (L-HPC), essence, talcum powder, m...

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PUM

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Abstract

An oral disintegrating tablet of paracetamol is prepared from paracetamol, water-soluble filler, disintegrant, lubricant, and wetting agent or adhesive.

Description

technical field [0001] The invention relates to a paracetamol orally disintegrating tablet and a preparation method thereof. technical background [0002] Acetaminophen is an antipyretic and analgesic drug of the acetanilide class. By inhibiting cyclooxygenase, selectively inhibiting the synthesis of prostaglandins in the hypothalamic thermoregulation center, resulting in peripheral blood vessel dilation and sweating to achieve antipyretic effect, and its antipyretic effect is similar to that of aspirin; by inhibiting the synthesis of prostaglandins, etc. It is a peripheral analgesic, its effect is weaker than that of aspirin, and it is only effective for mild and moderate pain. At present, among the antipyretic and analgesic drugs, paracetamol is considered to be the first choice drug, because it has few side effects and good curative effect. Acetaminophen is one of the most widely used drugs in the world, and it is the number one antipyretic and analg...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K31/167A61P29/00
Inventor 张宏武周桂荣李云立郭文敏张莉王莉芳
Owner CSPC ZHONGQI PHARM TECH (SHIJIAZHUANG) CO LTD
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