Nano spectrum endermatic medicinal paste and its preparation

Abstract

A medicinal picking for percutaneous absorption of medicine is composed of a substrate layer, the medicine-bearing layer consisting of nano-class Chinese medicine layer, nano-class far infrared layer, percutaneous absorption promoting layer and slow-releasing agent layer, an adhesive layer, and a protecting layer. Its preparing process is also disclosed. Its advantages are high medical effect and air permeability, and no irritation to skin.

Description

(1) Technical field: [0001] The invention relates to a drug patch for transdermal administration and a manufacturing method thereof, in particular to a nano-spectrum drug patch for transdermal drug administration and a manufacturing method thereof. (two) background technology: [0002] Transdermal delivery systems (TDS) refer to controlled-release preparations that are administered through the skin to achieve systemic therapeutic effects. TDS is a very promising dosage form, and its research has become one of the central contents of the development and research of the third generation of pharmaceutical preparations. There is a development process for transdermal external plasters. It has gone through four development periods from the traditional black plaster to the present: the first generation of patches: traditional patches, commonly known as dog skin plasters, which have the advantage of adopting the traditional Theoretically, it pioneered the internal and external trea...

AI Technical Summary

Problems solved by technology

There is a development process for transdermal external plasters. It has gone through four development periods from the traditional black plaster to the present: the first generation of patches: traditional patches, commonly known as dog skin plasters, which have the advantage of adopting the traditional Theoretically, it pioneered the internal and external treatment of bone diseases, and it is easy to carry; its disadvantages are 1. It is inconvenient to use, smells bad, airtight, and has a strong feeling of foreign body application; 2. Affected by the seasons, it is not easy to melt in cold weather. Open, it is hot and easy to melt, the drug loss is serious, and it is easy to contaminate the clothes, and it cannot be washed off; the second generation patch: chemical patch, such as common pain relief cream, joint cream, etc., its advantage is easy to carry , easy to use, low price; its disadvantages are 1. Zinc oxide adhesive plaster is used as the carrier, the skin cannot breathe, and allergic symptoms such as skin redness, ulceration, and spots are prone to occur; 2. Chemical glue is added in the production process, and the glue is mixed with medicine , the drug content is high, the distribution is uneven, only pay attention to the temporary analgesic effect, do not pay attention to the long-term curative effect, treat the symptoms but not the root cause; 3. The loss of drug ingredients is serious during the production process, and the application time is short

The third-generation patch: the improved patch, such as the common water-soluble patch in the world, has the advantage of focusing on the drug content on the basis of the third generation; its disadvantages are 1. Zinc oxide adhesive plaster is still used as the carrier, which is easy to Allergies occur; 2. The drug must be diluted with a water solvent before it can be applied, which is easy to volatilize, the application time is short, and the drug effect is not long-lasting; 3. The price is expensive

Some traditional Chinese medicines with short half-lives cannot achieve sustained or controlled release by general methods. Similar to western medicines with short half-lives, frequent administration is required to maintain the effective blood drug concentration in the body.

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