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Medical composite biological bone cement powder, bone cement liquid and composite biological bore cement

A bone cement and biological technology, which is applied in the field of medical composite bio-bone cement powder, bone cement liquid and medical composite bio-bone cement, can solve the problems of few researches on bone cement, poor injectability, difficult blood solidification, etc., to achieve Effects of improved injectability, increased fluidity, and increased compressive strength

Inactive Publication Date: 2003-03-19
SICHUAN UNIV +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the traditional inorganic calcium phosphate bone cement has good biocompatibility and osteoconductivity, and can be shaped according to the site to be repaired, its injectability is poor, and there are still problems such as difficulty in solidifying body fluids and blood.
At present, the research on injectable bone repair materials at home and abroad is mainly concentrated on inorganic bone cement materials, and there is little research on bone cement in the form of inorganic / organic composites.

Method used

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  • Medical composite biological bone cement powder, bone cement liquid and composite biological bore cement
  • Medical composite biological bone cement powder, bone cement liquid and composite biological bore cement

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] (1) Bone cement powder:

[0036] Synthesis of apatite: Feed calcium hydroxide and phosphoric acid at a calcium / phosphorus molar ratio of 1.60-1.67, and obtain apatite through the following reactions:

[0037] Dry the obtained apatite slurry at 120°C, grind it finely, pass through a 100-mesh sieve, and set aside.

[0038] Preparation of fine powder of polyamide components: Add polyamide 6 or polyamide 66 resin to the mixed solution of acetamide and calcium chloride (calcium chloride / acetamide ~ 20% g / ml), at 120°C-160°C Dissolve under heating conditions, cool to room temperature, pour into deionized water, very fine powder, centrifuge and wash 3 times, dry at 60-80°C, pass through a 100-mesh sieve, and set aside.

[0039] Preparation of bone cement fine powder: mix the above-mentioned apatite fine powder and polyamide 6 or polyamide 66 fine powder in a ratio of 1:1 by weight, grind to fine powder, wash twice with distilled water, dry again, and grind to fine powde...

Embodiment 2

[0045] Except for the ratio of 1:0.4 by weight when mixing the fine powder of apatite and the fine powder of polyamide 6 when preparing the fine powder of bone cement, the rest of the preparation methods and processes refer to Example 1. The apatite content in the injectable bone cement material obtained in this example can reach about 70%.

Embodiment 3～4

[0047] In Example 1 and Example 2, the mixing ratio of bone cement fine powder and bone cement liquid was changed to be lower than 1:1 when preparing bone cement, and the rest of the preparation methods and processes were referred to Example 1. Non-injectable bone cement materials with apatite content of about 50% and about 70% can be obtained respectively.

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Abstract

The medical composite biological bone cement powder is mixture of apatite and polyamide component, and the polymaide component is fine powder formed by dissolving polyamide 6 or polyamide 66 in acetamide solution containing calcium chloride. The bone cement liquid is ethanol solution of calcium chloride. The medical composite biological bone cement is homogeneous mixture of the bone cement powder and the bone cement liquid and includes two types of one capable of being injected and one incapable of being injected. The bone cement has good biocompatibility and bone conductibility and may be produced into injected bone cement, which is injected via hypodermic injection to bone repairing part for treating fracture and re-constructing gone defection.

Description

technical field [0001] The invention relates to a composite biological bone cement powder, a bone cement liquid and a corresponding medical composite biological bone cement used for replacing and repairing bone tissue defects in surgical operations. Background technique [0002] Bone cement is a kind of bone repair material that is easy to operate in clinical surgery, can be shaped and cured arbitrarily like cement according to needs, and has a wide range of applications in the repair and replacement of bone and tooth defects, plastic surgery, and beauty. One material that can be used as bone cement at present is polymethyl methacrylate (PMMA). Because its composition is completely different from that of natural bone tissue, its biocompatibility as a bone substitute or filling material for bone defects There are big problems. Although the traditional inorganic calcium phosphate bone cement has good biocompatibility and high bioactivity, its mechanical strength is too low, i...

Claims

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Application Information

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IPC IPC(8): A61K31/785A61L27/18A61P19/08C08L77/06
Inventor 李玉宝魏杰
Owner SICHUAN UNIV
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