Productive process for Rufloxaxin Hydrochloride raw material

Abstract

The production process of raw material medicine of rufluoxin hydrochloride is an improvement on oil technological process, and is aimed at overcome defects of old technological process whose production yield is low, cost is high and by-product can pollute environment. It mainly improves second step and sixth step of old technological process, in second step, in the reaction container the ethyl alcohol, water ammonium chloride are added, iron powder is added while stirring, the dilute hydrochloric acid is slowly added, heated to reflux state, B is dropped in slowly, pH value is retained to 5-6, reacted for 1 hr, then TLC is ued to test reaction end point; and in sixth step, in reaction container the F, boron trifluoride etherate and acetone are added, heated to 58-63 deg.C and reflux reaction is made for 3-3.5 hr. Said invention can reduce production cost and raise product yield.

Description

technical field [0001] The invention relates to a production process of medicines, in particular to an improved production process of rufloxacin hydrochloride crude drug. Background technique [0002] The production process of rufloxacin API was limited to laboratory experiments at that time, and there were few considerations in the selection of certain raw materials, the capacity of production equipment, and the operating conditions of certain steps, which led to many problems in production, such as: production receipts. The rate is lower, the cost is higher, and the environment is polluted. In particular, there are many problems in the second and sixth steps. [0003] In the production process route of the former second step amide C, in the reaction vessel equipped with a stirrer, a thermometer, a dropping funnel and an addition funnel, add nitro compound A, ethanol, water, and ammonium chloride; be warming up to 40 ° C ; Add hydrochloric acid dropwise...

AI Technical Summary

Problems solved by technology

[0006] In this process route, 40% fluoboric acid is a very corrosive strong acid at a high temperature of 100-120 ° C. It can corrode enamel, stainless steel, polyphenylene sulfide, glass, etc., which causes great difficulties in equipment selection. , causing expensive production costs, corroding the reaction vessel, consuming a large amount of fluoboric acid, and producing by-products, which reduces the yield. In the post-processing process, because fluoboric acid cannot be recovered, certain pollution is generated