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Anisodamine ointment for treating frostbite and sclerema neonatorum and method for preparing same

A technology for anisodamine and scleredema, applied in the field of pharmaceutical preparations, can solve the problems of ineffective curative effect, inability to cure in time, long treatment time, etc.

Inactive Publication Date: 2007-03-28
康佳兰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because it cannot be cured in time, there are limitations in treatment
[0004] There are various liquid medicines and topical ointments to treat frostbite, but the treatment time is long and the curative effect is not obvious

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] December 2004-January 2005, follow-up of chilblain outpatients: main manifestations: redness and swelling in different degrees on ears, face, back of hands and toes, dark red skin. At the same time, there is pain, pain, and itching in these chilblains.

[0018] Among them are two patients, one is a 35-year-old man who is a vegetable farmer; the other is a 38-year-old woman who sells vegetables in the market. Both patients had different degrees of ulceration on the back of their hands and came to the clinic. After cleaning, apply anisodamine ointment, and do venous blood and liver function tests. The following table:

[0019] Total protein

[0020] Healed after 6 days with ointment. In this outpatient case, there was no change in the routine tests of venous blood and liver function before and after medication.

Embodiment 2

[0022] At the end of the investigation, peripheral blood was measured on 8 people, and 6 of them were comprehensively counted. Before medication, white blood cells 5×10 3 ~6×10 3 u / L, hemoglobin concentration 10.5-13.2g, lymphocyte percentage 38-40%, monocyte percentage 3-4%, neutrophil percentage 50-65%; after medication, there is no obvious change in re-examination, generally fluctuating at 0 Between ~3.

Embodiment 3

[0024] 147 patients with scleredema of newborns, including 72 females and 75 males, all had peripheral blood examinations. The average white blood cells ranged from 15×10 to 20×10u / L, and 2 cases ranged from 21×10u / L. The hemoglobin concentration The fluctuation was 180-195g / L, and the rest remained unchanged. In the observation of pediatric inpatient treatment, sclerosis can be cured within 2 to 5 days after medication, and the effect is obvious.

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PUM

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Abstract

The present invention relates to medicine with organic effective component, and aims at one kind of ointment compounded with anisodamine and capable of curing frostbite and sclerema neonatorum in relatively short time. The ointment is compounded with anisodamine in 15-20 wt% and chlorphenamine 5-15 wt% except medical vaseline. The supplementary material includes metronidazole and / or prednisone and proper amount of vitamin E. The preparation process includes heating vaseline, mixing with other components, cooling and packing in box. The present invention has simple preparation process, low cost, convenient use and obvious treating effect.

Description

Technical field [0001] The invention belongs to pharmaceutical preparations containing organic active ingredients. Background technique [0002] Anisodamine is an M-choline receptor blocker, which binds to M-choline receptors, can relieve smooth muscle spasm caused by acetylcholine, and has a relaxing effect on gastrointestinal smooth muscle; inhibits glandular secretion; relieves the effect of vagus nerve on the heart Inhibition, faster heartbeat; dilated pupils, etc. Because it is not easy to pass through the blood-cerebrospinal fluid barrier, its central symptoms are weaker than atropine. Inhibition of secretion, mydriasis, and relief of smooth muscle spasm are weak, but the toxicity and side effects are low. It is clinically used orally, intramuscularly or intravenously to relieve smooth muscle spasm, gastrointestinal colic, biliary tract spasm, and organophosphate poisoning. [0003] Neonatal scleredema has a neonatal mortality rate of 30-50%...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/46A61K31/4402A61K31/573A61K9/06A61P17/02
Inventor 康佳兰
Owner 康佳兰
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