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High molecular chemical slow releasing sterilizer containing diniconazole as biological active component

A bioactive component, polymer-based technology, applied in the field of agricultural chemicals, can solve the problems of large consumption of polymer substrates, no obvious advantages in production cost, low content of active molecules, etc., to achieve high content of active molecules, agricultural Cost reduction and long lasting effect

Inactive Publication Date: 2007-01-17
中国中化股份有限公司 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In order to overcome the shortcomings of the physical type of diniconazole polymer controlled-release dosage forms, "the consumption of polymer substrate is large, the content of active molecules is low, a large number of polymer residues will easily cause new environmental pollution, and there is no obvious advantage in production cost" , to develop high-efficiency, environmentally friendly green pesticides to meet the needs of agricultural production. The present invention proposes a new technical solution: link the diniconazole fungicide to the polymer compound carrier in the form of a covalent bond to obtain a polymer chemical slow-release fungicide

Method used

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  • High molecular chemical slow releasing sterilizer containing diniconazole as biological active component
  • High molecular chemical slow releasing sterilizer containing diniconazole as biological active component
  • High molecular chemical slow releasing sterilizer containing diniconazole as biological active component

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] The preparation of example 1 polymer I

[0032]In a 125 ml four-necked flask equipped with a thermometer, a stirrer, a reflux condenser and a nitrogen device, add 60 ml of dry N,N-dimethylacetamide (DMAC) and 0.714 g (2.8 mmol) of 4 , 4'-diphenylmethane diisocyanate (MDI), nitrogen, stirring, heated to 100-110 ° C, dropwise added 0.920 g (2.8 mmol) of diniconazole and 10 ml of dry DMAC solution. After adding, keep stirring for about 1 hour, add 3.200 g of polyvinyl alcohol (polymerization degree: 1700:, alcoholysis degree: 99%) and 10 ml of dry DMAC solution, and react at 100±5°C for about 2 hours to the end. After cooling down to room temperature, a light brown gel was obtained as the crude product. The product was precipitated by methanol, filtered, and vacuum-dried to obtain 2.05 g of light yellow solid, which was the final product—Polymer I: 18% diniconazole content (weight content).

example 2

[0033] The preparation of example 2 polymer II~polymer V

[0034] Referring to the method of Example 1, polyvinyl alcohol with a degree of polymerization of 100, 1450, 2600 and 7,500,000 to 10,000,000 was used as a carrier polymer to synthesize polymers II to V, as shown in Table 1:

[0035] polymer

Bridging agent

Alcoholysis degree of polyvinyl alcohol%

Polymerization

II

MDI

84

100

III

MDI

88

1,450

IV

MDI

99

2,600

V

MDI

99

7,500,000～

10,000,000

[0036] Infrared Spectrum of Polymer I~Polymer V:

[0037] IR v max : 3600~3200cm -1 (alcohol-OH characteristic absorption), 3400~3000cm-1 (N-H stretching vibration of amide), 2980~2840cm -1 (saturated hydrocarbon C-H stretching vibration), 1730cm -1 (s, C=O), 1650cm -1 、1620cm -1 、1580cm -1 、1510cm -1 (Olefin C=C, benzene ring skeleton vibration), 1560cm -1 (m, C=N), 1260cm...

example 3

[0038] Example 3 Hydrolysis Release of Polymer I~Polymer V Active Components

[0039] Hydrolysis release test According to the literature (El-Refaie Kenawy, et al., J Appl Polym Sci, 2001, 80: 415-421), 100 mg of pulverized polymer (DMP) was placed in 100 ml of buffer solution In the volumetric flask, keep the water bath at a constant temperature of 25°C without stirring. Buffer solutions with pH=4, 7, and 9 were respectively prepared with acetic acid-sodium acetate, mixed phosphate and ammonium chloride-ammonia water. Periodically extract the test solution and use the HPLC method (Waters high-performance liquid chromatography, Waters 510pump, detector Waters486, 254nm is the detection wavelength) to analyze the content of the active component released by hydrolysis-diniconazole. The hydrolysis experiment result of polymer (DMP) shows: in the buffer solution of different pH value, the initial release concentration of active component is all very high, and release amount can r...

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Abstract

The present invention discloses high molecular chemical slow releasing bactericide containing diniconazole as bioactive component. The present invention has the polymer unit structure as shown in the expression. The present invention also discloses the preparation process of the high molecular chemical slow releasing bactericide. The high molecular chemical slow releasing bactericide itself has no bactericidal activity and has its chemical bond broken under the use environment to release enough active components. The high molecular chemical slow releasing bactericide may be used as agricultural bactericide.

Description

technical field [0001] The invention belongs to the field of agricultural chemicals. The invention relates to a controlled-release polymer bactericide, a preparation method and an application thereof. More precisely, it relates to a polymer type chemical slow-release bactericide and its preparation method and application. Background technique [0002] The polymer controlled slow-release pesticide is a new type of pesticide slow-release agent researched and developed based on people's emphasis on environmental protection and increasingly strict regulations on the toxicity, safety and residual effect of pesticides. It uses the stability and adhesion of polymer materials to overcome the shortcomings of small molecule pesticides that are easily lost by wind, rain, microorganisms and other factors. Generally, it does not exhibit biological activity, but it can be used in a pesticide application environment with a little The active ingredient is slowly released higher than the e...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A01N43/653A01N25/10C08F261/04A01P3/00
Inventor 刘冬雪台立民徐龙鹤司乃国喻滔
Owner 中国中化股份有限公司
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