Gentamicin, preparation method and uses thereof

A gentamicin, a new generation of technology, applied in the field of antibiotic fermentation, can solve the problems that the side effects of gentamicin have not been fundamentally improved, and the additives have not been promoted, and achieve the effect of C1 with less toxic and side effects

Inactive Publication Date: 2006-12-20
窦德献
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to various reasons, the additive has not been promoted
At ...

Method used

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  • Gentamicin, preparation method and uses thereof
  • Gentamicin, preparation method and uses thereof
  • Gentamicin, preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: High-yield culture method of gentamicin C1. Contains 11 grams / liter of corn flour, 25 grams / liter of starch, 32 grams / liter of soybean flour, 0.01 grams / liter of potassium nitrate, 5 grams / liter of calcium carbonate, 0.25 grams / liter of ammonium sulfate, 4.5 grams / liter of peptone, chloride Add 2.5 g / L glutamic acid, pH 7.2, culture temperature 35°C, fermentation time 90 hours to Micromonospora rubrum conventional fermentation medium with cobalt 15 mg / L.

Embodiment 2

[0033] Embodiment 2: In the fermentation medium identical with embodiment 1, contain sodium glutamate 2.5 grams / liter, replace glutamic acid in embodiment 1, all the other are all the same with embodiment 1.

Embodiment 3

[0034] Embodiment 3: in the fermentation medium identical with embodiment 1, contain glutamine 2.5 g / liter, replace the glutamic acid in embodiment 1, all the other are identical with embodiment 1.

[0035] The measured value of embodiment 1-3, see table 1.

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Abstract

The present invention relates to new generation of gentamicin and its preparation process and use. It is prepared via adding glutamic acid, sodium glutamate or glutamic amine into the conventional deep red micromonad fermenting culture medium comprising corn powder, starch, yeast powder or soybean powder, potassium nitrate, calcium carbonate, ammonium sulfate, peptone and cobalt chloride, one or several kinds of additives are added selected from: rice powder, millet powder, fructose, glycosamine, ferric gluconate, zinc chloride, ferrous citrate, ferrous lactate, vitamin B12, etc. The gentamicin of the present invention, gentamicin C1, has the advantages of high gentamicin C1 content and less toxic side effect. The product of the present invention is one kind of antibiotic for human and animal.

Description

technical field [0001] The invention relates to antibiotic fermentation, in particular to the fermentation preparation of a new generation of gentamycin with increased content of high-quality components, a preparation method and use thereof. Background technique [0002] Gentamicin is an antibiotic discovered in the United States in 1963. It is widely used clinically all over the world. In 1967, China began to produce gentamicin. At present, China has become the main producer of gentamicin in the world and the largest supplier of gentamicin in the world. [0003] Gentamicin is an antibiotic produced by Micromonospora purpurea. It is a multi-component aminoglycoside antibiotic, and its molecule is composed of three ring structures, namely sugar amine, 2-deoxystreptamine and crimson amine. Gentamicin consists of differently methylated components due to the presence of methylation at different positions on the crucian amine. There are clear regulations on the quality of ge...

Claims

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Application Information

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IPC IPC(8): C07H15/234C12P19/48
Inventor 窦德献
Owner 窦德献
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