Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Gentamicin, preparation method and uses thereof

A gentamicin, a new generation of technology, applied in the field of antibiotic fermentation, can solve the problems that the side effects of gentamicin have not been fundamentally improved, and the additives have not been promoted, and achieve the effect of C1 with less toxic and side effects

Inactive Publication Date: 2006-12-20
窦德献
View PDF1 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to various reasons, the additive has not been promoted
At present, the side effects of gentamicin have not been fundamentally improved

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Gentamicin, preparation method and uses thereof
  • Gentamicin, preparation method and uses thereof
  • Gentamicin, preparation method and uses thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: High-yield culture method of gentamicin C1. Contains 11 grams / liter of corn flour, 25 grams / liter of starch, 32 grams / liter of soybean flour, 0.01 grams / liter of potassium nitrate, 5 grams / liter of calcium carbonate, 0.25 grams / liter of ammonium sulfate, 4.5 grams / liter of peptone, chloride Add 2.5 g / L glutamic acid, pH 7.2, culture temperature 35°C, fermentation time 90 hours to Micromonospora rubrum conventional fermentation medium with cobalt 15 mg / L.

Embodiment 2

[0033] Embodiment 2: In the fermentation medium identical with embodiment 1, contain sodium glutamate 2.5 grams / liter, replace glutamic acid in embodiment 1, all the other are all the same with embodiment 1.

Embodiment 3

[0034] Embodiment 3: in the fermentation medium identical with embodiment 1, contain glutamine 2.5 g / liter, replace the glutamic acid in embodiment 1, all the other are identical with embodiment 1.

[0035] The measured value of embodiment 1-3, see table 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention relates to new generation of gentamicin and its preparation process and use. It is prepared via adding glutamic acid, sodium glutamate or glutamic amine into the conventional deep red micromonad fermenting culture medium comprising corn powder, starch, yeast powder or soybean powder, potassium nitrate, calcium carbonate, ammonium sulfate, peptone and cobalt chloride, one or several kinds of additives are added selected from: rice powder, millet powder, fructose, glycosamine, ferric gluconate, zinc chloride, ferrous citrate, ferrous lactate, vitamin B12, etc. The gentamicin of the present invention, gentamicin C1, has the advantages of high gentamicin C1 content and less toxic side effect. The product of the present invention is one kind of antibiotic for human and animal.

Description

technical field [0001] The invention relates to antibiotic fermentation, in particular to the fermentation preparation of a new generation of gentamycin with increased content of high-quality components, a preparation method and use thereof. Background technique [0002] Gentamicin is an antibiotic discovered in the United States in 1963. It is widely used clinically all over the world. In 1967, China began to produce gentamicin. At present, China has become the main producer of gentamicin in the world and the largest supplier of gentamicin in the world. [0003] Gentamicin is an antibiotic produced by Micromonospora purpurea. It is a multi-component aminoglycoside antibiotic, and its molecule is composed of three ring structures, namely sugar amine, 2-deoxystreptamine and crimson amine. Gentamicin consists of differently methylated components due to the presence of methylation at different positions on the crucian amine. There are clear regulations on the quality of ge...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07H15/234C12P19/48
Inventor 窦德献
Owner 窦德献
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com