Orally disintegrating tablet of gypenosides and its preparation process
A technology of orally disintegrating tablets and total saponins, which can be used in medical preparations containing active ingredients, pill delivery, metabolic diseases, etc., and can solve problems such as high manufacturing and medical costs, great pain for patients, and difficulty in taking them
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Embodiment 1
[0037] Embodiment one direct flavoring method
[0038] 1. Prescription
[0039] 1. Raw materials - Gypenosides 20.0g;
[0040] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;
[0041] 3. Filling agent - mannitol 58.5g;
[0042] PROSOLV SMCC 5.0g;
[0043] 4. Flavoring agent - aspartame 1.0g;
[0044] Ginseng essence 1.0g;
[0045] 5. Disintegrant—cross-linked polyvinylpyrrolidone 8.0g;
[0046] L-HPC 4.0g;
[0047] 6. Glidant - micropowder silica gel 1.0g;
[0048]7. Lubricant—sodium stearyl fumarate 1.0 g.
[0049] The total weight is 100g, and a total of 1000 pieces are made.
[0050] 2. Preparation method
[0051] 1) Gypenoside glycosides raw materials are taken and pulverized, granulated with polyvinylpyrrolidone K-30, passed through a 26-mesh sieve, and set aside;
[0052] 2) Pass the micronized silica gel, ginseng essence, PROSOLV SMCC and aspartame through a 40-mesh sieve, mix evenly, then add the granulated Gypenosides granules, mix evenly, and set aside;
[...
Embodiment 2
[0055] Example 2 Powder coating taste masking method
[0056] 1. Prescription
[0057] 1. Raw material - Gypenosides 20.0g;
[0058] 2. Coating material - Eudragit E100 3.5g;
[0059] Eudragit NE30D (dry) 1.5g;
[0060] 3. Filling agent - mannitol 55.5g;
[0061] Microcrystalline cellulose 5.0g;
[0062] 4. Flavoring agent - aspartame 1.0g;
[0063] Ginseng essence 1.0g;
[0064] 5. Disintegrant—cross-linked polyvinylpyrrolidone 6.0g;
[0065] L-HPC 4.0g;
[0066] 6. Glidant - micronized silica gel 1.5g;
[0067] 7. Lubricant—sodium stearyl fumarate 1.0 g.
[0068] The total weight is 100g, and a total of 1000 pieces are made.
[0069] 2. Preparation method
[0070] 1) Take Eudragit E100 and Eudragit NE30D and Eudragit NE30D are dissolved in more than 95% pharmaceutical industrial ethanol and diluted to a certain concentration for later use;
[0071] 2) Take Gypenosides and place them in an ebullating bed to boil, spray the above solution at a certain speed for pow...
Embodiment 3
[0074] Embodiment three effervescent agent flavoring method
[0075] 1. Prescription
[0076] 1. Raw materials - Gypenosides 20.0g;
[0077] 2. Adhesive - polyvinylpyrrolidone K-30 0.5g;
[0078] 3. Effervescent agent - citric acid 12.5g;
[0079] Sodium bicarbonate 10.0g;
[0080] 4. Filling agent - mannitol 33.0g;
[0081] PROSOLV SMCC 5.0g;
[0082] 5. Flavoring agent - aspartame 1.0g;
[0083] Orange essence 1.0g;
[0084] 6. Disintegrant—cross-linked polyvinylpyrrolidone 10.0g;
[0085] L-HPC 5.0g;
[0086] 7. Glidant - micropowder silica gel 1.0g;
[0087] 8. Lubricant—1.0 g of sodium stearyl fumarate.
[0088] The total weight is 100g, and a total of 1000 pieces are made.
[0089] 2. Preparation method
[0090] 1) Mix gypenosides and citric acid raw materials, pulverize them, granulate with polyvinylpyrrolidone K-30, pass through a 26-mesh sieve, and set aside;
[0091] 2) Take sodium bicarbonate and pulverize it, granulate it with polyvinylpyrrolidone K-30...
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