Composition for dispelling effects of alcohol and protecting liver and application thereof

A technology for hangover and liver protection and composition, which is applied in the directions of drug combination, drug delivery, food science, etc., to achieve the effects of promoting elimination, hangover and liver protection, and safe and stable drug efficacy.

Pending Publication Date: 2022-07-15
恩众(山东)数字健康发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But so far, it has not been reported whether the combination of kudzu root, kudzu flower, chrysanthemum extract, yeast extract and garlic extract has the effect of relieving alcohol and protecting the liver. Whether it can play a synergistic effect has not been reported

Method used

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  • Composition for dispelling effects of alcohol and protecting liver and application thereof
  • Composition for dispelling effects of alcohol and protecting liver and application thereof
  • Composition for dispelling effects of alcohol and protecting liver and application thereof

Examples

Experimental program
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Effect test

preparation example Construction

[0041] In the present invention, the preparation method of the Chinese medicinal material extract includes: mixing the Chinese medicinal material with 60-85% ethanol solution according to a material-to-liquid ratio of 1:8-15, soaking for 7-12 hours, and heating and refluxing for 1.5-3 hours to obtain the medicinal liquid. Among them, the ethanol concentration is preferably 80%, the material-to-liquid ratio is preferably 1:10-12g / mL, the soaking time is preferably 8-10h, and the heating and refluxing time is preferably 2-2.5h. The heating and refluxing operation of the present invention adopts a conventional heating and refluxing device, and the heating temperature is 40-60°C, more preferably 50-55°C. Through the above treatment, the present invention can effectively extract the flavonoids contained in the traditional Chinese medicine mixture, and the extraction rate and flavonoid content are high, and meanwhile, the content of impurities in the extract can be reduced, so that t...

Embodiment 1

[0072] In this example, an orthogonal design is carried out on the extraction method of the Chinese herbal medicine extract.

[0073] The mixed powder of pueraria, pueraria and chrysanthemum with a mass ratio of 1:1:2 was taken, mixed with an ethanol solution according to the material-liquid ratio, soaked for 10 hours, and heated and refluxed to obtain a medicinal liquid. The extraction process parameters were subjected to orthogonal experiments according to Table 1, and the optimal extraction method was subsequently determined by evaluating the extraction rate of active ingredients.

[0074] Table 1 Extraction method orthogonal design table

[0075]

[0076] Taking puerarin, irisin, and rutin as representative components, the content of the above-mentioned effective substances in the extract was determined by high performance liquid chromatography. The results are shown in Table 2.

[0077] Table 2 Active ingredient content in the extract (%, w / w)

[0078]

[0079] As...

Embodiment 2

[0081] In this example, a hangover-relieving and liver-protecting composition was prepared.

[0082] (1) Preparation of Chinese herbal medicine extracts:

[0083] Pueraria lobata: Pueraria lobata: Chrysanthemum was mixed in a mass ratio of 1:1:2, and 80% ethanol solution was added in a ratio of 1:15g / mL of material to liquid, soaked for 10h, and heated (55°C) to reflux for 3h. The obtained medicinal liquid is directly passed through a 200-mesh sieve, the medicinal residues are filtered off, and the obtained traditional Chinese medicine extract is concentrated and dried. Grind the dry paste and pass it through a 40-mesh sieve, set aside.

[0084] (2) Preparation of yeast extract I:

[0085] Dry yeast was added with 0.05mol / L Na according to the ratio of material to liquid 1:4g / mL 2 HPO 4 The solution was kept in a water bath at 37°C for 3 hours with constant stirring, and extracted at room temperature for 3 hours after the end of the incubation. The mixed extract was filte...

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Abstract

The invention provides a hangover-alleviating and liver-protecting composition and application thereof, and belongs to the technical field of medicines and foods.The hangover-alleviating and liver-protecting composition comprises 35-45 parts of traditional Chinese medicinal material extract, 0.2-0.4 part of yeast extract I, 0.2-0.4 part of yeast extract II and 0.3-0.5 part of garlic extract, and traditional Chinese medicinal materials are obtained by mixing radix puerariae, flos puerariae and flos chrysanthemi according to the mass ratio of (1-3): (1-3): (2-6). The composition disclosed by the invention can be used for effectively removing oxygen free radicals and reducing the harm of the oxygen free radicals to liver cells, has the physiological activities of resisting bacteria, resisting inflammation, enhancing immunity and the like, and achieves good effects of dispelling the effects of alcohol and protecting the liver.

Description

technical field [0001] The invention belongs to the technical field of medicine and food, and in particular relates to a composition for detoxifying and protecting the liver and application thereof. Background technique [0002] Alcoholic liver disease (ALD) is a liver disease caused by long-term heavy drinking, including alcoholic fatty liver (AFL), alcoholic hepatitis (AH), alcoholic liver fibrosis (AHF) and alcoholic liver cirrhosis (AC), etc. 4 categories. Alcoholism kills 2.5 million people worldwide each year, accounting for 4% of all deaths, and 40% of deaths from cirrhosis are due to ALD. Alcohol abuse, especially ALD caused by alcohol abuse in young people, has become a major public health problem in the whole society. [0003] Oxidative stress (OS) during ethanol metabolism plays a crucial role in the pathogenesis of alcoholic liver injury. Hepatocyte damage is closely related to reactive oxygen species (ROS) damage. Alcohol metabolism produces a large amount of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8962A61K9/46A61P39/02A61P1/16A23L33/105A23L33/145
CPCA61K36/488A61K36/287A61K36/064A61K36/8962A61K9/0007A61K9/20A61P39/02A61P1/16A23L33/105A23L33/145A61K2236/333A61K2236/51A23V2002/00A61K2300/00A23V2200/334A23V2250/21A23V2250/212A23V2250/218
Inventor 宋立孝谭余庆杨米一
Owner 恩众(山东)数字健康发展有限公司
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